2026-04-08T15:18:09Z http://oaini.phaidrabg.rs/oai2.php

oai:eteze.ni.ac.rs:73 2016-08-22T00:00:00Z 2

Kinetičko određivanje nekih analgetika i sedativa : doktorska disertacija Pavlović, Aleksandra N. Analgetici, sedativi, reakcija izmene liganada, kinetičko određivanje Analgesics U radu su predložene nove kinetičko-spektrofotometrijske metode za određivanje mikro količina analgetika, derivata salicilne,propionske i aminofenilacetatne kiseline (acetilsalicilna kiselina, ibuprofen, diklofenak) i sedativa, derivata, etanolamina i benzodijazepina (dimenhidrinat, klonazepam, dijazepam) a na osnovu njihovog uticaja na ravnotežu u kompleksirajućoj sredini (1-nitrozo-2-naftol / joni bakra, kobalta i kadmijuma). Razrađenim medotama pomenute aktivne supstance su određene u farmaceutskim preparatima i humanom kontrolnom serumu. Univerzitet u Nišu Prirodno-matematički fakultet Mitić, Snežana 2009 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=73 https://fedorani.ni.ac.rs/fedora/get/o:589/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533078934 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:145 2015-10-15T00:00:00Z 2

Teorija optimalnosti i teorija metafore u svetlu muzičke i jezičke kompetencije : doktorska disertacija Antović, Mihailo Teorija optimalnosti, Teorija metafore Ovaj rad bavi se paralelama između pojedinih aspekata muzičke i jezičke kognitivne sposobnosti. U prvom, teorijsko-lingvističkom delu rada, razmatramo dva savremena konstrukta u kognitivnoj lingvistici u širem smislu: teoriju optimalnosti i teoriju metafore. Pri analizi teorije optimalnosti, najpre se iznosi istorijski pregled razvitka generativne lingvistike, a zatim opisuje trenutno stanje u ovoj lingvističkoj paradigmi, sa posebnim osvrtom na primenljivost teorije optimalnosti na različitim nivoima jezičke analize (fonološkom, morfološkom, sintaksičkom i semantičkom). Ponuđen je i kraći osvrt na njen odnos prema trenutno dominantnom jezičkom opisu u angloameričkom svetu, minimalističkom programu N.Čomskog. Iznesena je i analiza nekih pojava u srpskom jeziku instrumentima teorije optimalnosti: problema »grešaka« izvornih govornika pri jednačenju po zvučnosti, pitanja reduplikacije, pripajanja klitika, tetopikalizacije i izbora optimalnog reda reči. Po pitanju teorije metafore, najpre se daje istorijski pregledrazvitka savremene kognitivistič ke semantike, ukratko analiziraju postulati tri vodeće savremene angloameričke semantičke škole, te daje detaljna analiza razvoja teorije metafore u okviru kognitivne lingvistike. Takođe, razmatra se i današnji odnos konceptualne teorije metafore Lejkofa i Džonsona i teorije stapanja Fokonijea i Tarnera. Ponuđena je i analiza određenog broja metafora iz srpskog pisanog korpusa (iz kolekicje M. Petrovića Alasa) i zaključeno da postulati konceptualne teorije metafore mogu da se bez već ih izmena preslikaju i na naš jezik. Univerzitet u Nišu Filozofski fakultet Vidanović, Đorđe 2007 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=145 https://fedorani.ni.ac.rs/fedora/get/o:693/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533024918 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:148 2015-10-15T00:00:00Z 2

Kontroverze oporezivanja dohotka fizičkih lica : doktorska disertacija Đorđević, Marina Porezi, Dohodak fizičkih lica, Porez na dohodak građana U ovom radu biće učinjen pokušaj razjašnjavanja kontroverzi u oporezivanju dohotka fizičkih lica. Prva, na koju se nailazi, tiče se izbora poreskog obveznika. Neophodno je, uz uvažavanje osnovnih principa oporezivanja načiniti pravi izbor poreskog obveznika, tj. odabrati pojedinca ili porodicu. Zatim, poreska vlast nailazi na sledeću dilemu, a to je odabir poreske stope. Treba odlučiti, da li poreskom sistemu konkretne države više odgovaraju progresivne ili proporcionalne (flat) poreske stope. Prilikom oporezivanja dohotka fizičkih lica stalno prisutan konflikt između principa pravičnosti i efikasnosti. Poreska vlast i u ovom slučaju treba da postupi u skladu sapotrebama i preferencijama privrede. Međutim, dilema kojoj će biti posvećena najveća pažnja u radu, odnosi se na odabir osnovice za oporezivanje. Najveći broj zemalja uzima za poresku osnovicu prilikom oporezivanja dohotka fizičkih lica zbir neto prihoda iz različitih izvora, tj. primenjuje sintetičko oporezivanje dohotka. Univerzitet u Nišu Ekonomski fakultet Đurović-Todorović, Jadranka, 1968- Raičević, Božidar, 1941- Krstić, Borko, 1950- 2008 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=148 https://fedorani.ni.ac.rs/fedora/get/o:695/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/34989839 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:149 2015-10-15T00:00:00Z 2

Proučavanje sistema: mono i disulfovani produkti hidrohinona-joni metala : doktorska disertacija Tošić, Snežana B., 1965- hidrohinon, mono i disulfonovani hidrohinon; Fe(III); Cu(II); H2O2; kompleks; oksidacija; metode određivanja; primena Spektroofotometrijski su proučavane ravnoteže u kompleksirajućoj sredini Fe(III)-sulfonovani proizvodihidrohinona (moni i di); određeni optimalni uslovi građenja kompleksa, sastav, konstanta stabilnosti, termodinamički parametri reakcije, razvijene nove metode određivanja Fe(III) u rastvoru, ispitana reproduktivnost i selektivnost sa primenom na realne uzorke. Takođe spektrofotometrijski je praćena kinetika reakcije oksidacije pomenutih proizvoda hidrohinona vodonik peroksidom u kiseloj sredini u prisustvu Fe(III) i Cu(II) kao katalizatora. Određeni su optimalni uslovi, redovi reakcija, postavljene kinetičke jednačine ispitivanih procesa, date kalibracione prave za određivanje ispitivanih jona, ispitana reproduktivnost i selektivnost predloženih metoda. Metode primenjene na realnim uzorcima voća i povrća. Univerzitet u Nišu Prirodno-matematički fakultet Obradović, Mirjana 2009 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=149 https://fedorani.ni.ac.rs/fedora/get/o:696/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533085590 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:150 2015-10-15T00:00:00Z 2

Kinetika bazno-katalizovane metanolize suncokretovog ulja na niskim temperaturama : doktorska disertacija Stamenković, Olivera 1973- Suncokretovo ulje U ovoj disertaciji ispitivana je sinteza metil estara masnih kiselina (MEMK) ulja suncokreta reakcijom metanolize pod uslovima homogene (katalizator: kalijum hidroksid), heterogene (kalcijum oksid, kalcijum hidroksid, kalcijum karbonat i magnezijum oksid) i homogeno-heterogene (barijum hidroksid) bazne katalize. Metanoliza suncokretovog ulja je izvedena šaržno, na atmosferskom pritisku i niskim temperaturama (60 stepeni Celzijusa ili nižim). Kvalitativni i kvantitativni sastav reakcione smeše je određivan metodom tankoslojne (TLC i HPTLC) i tečne (HPLC) hromatografije. Veličina kapi dispergovane alkoholne faze u emulziji sa uljem ili u reakcionoj smeši je merena sa mikrofotografija, uz pomoć odgovarajućeg računarskog programa. Intenzitet mešanja utiče na veličinu i raspodelu veličine kapi emulgovanog metanola u ulju. Srednji Sauter-ov prečnik kapi je korelisan sa brzinom mešanja u skladu sa modelom smicajnih sila u graničnom sloju i modifikovanom teorijom Kolmogorova, koja uključuje periodične i slučajne promene režima strujanja. Krive raspodele veličine kapi postaju simetrične i pomeraju se ka manjim vrednostima veličine kapi sa povećanjem brzine mešanja. Univerzitet u Nišu Tehnološki fakultet Veljković, Vlada 2008 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=150 https://fedorani.ni.ac.rs/fedora/get/o:697/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/33906703 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:152 2015-10-15T00:00:00Z 2

Projektovanje i optimizacija električnih kontakata i termičkih prekidača : doktorska disertacija Prijić, Aneta Prekidači This Dissertation deals with the design and optimization of two kinds of metal based switching devices: i) riveted electrical contacts which are studied in the first part, and ii) S-type thermal cutoffs which are considered in the second part. Theoretical basis of electric contacts' design given in Chapter 1 is employed for contact material selection, proper set of contacts' geometry and dimension values and minimal contact force determination. Contacts of solid and clad types with rounded head are considered within two supporting structures. 3-D simulation of mechanical, electrical and thermal characteristics of selected contacts is steady state regime is performed and obtained results are presented in Chapter 2. Simulations are carried out in coupled domains by direct method. Special emphasis is given on dependencies of operating temperature and maximum equivalent stress in contacts under various working conditions. On the basis of the obtained results, optimization of riveted electric contacts is realized by appropriate selection of contact material, determination of geometry and dimensions of contacts and definition of rated current values. Optimization was conducted by functional, economic, ecological and reliability points of view. Possibilities of mounting the contacts in specific switching devices with predefined rated currents, as well as number of switching cycles before the failure are ore outlined. Analyzed dependencies and optimization results are described in detail in Chapter 3. Univerzitet u Nišu Elektronski fakultet Pešić, Biljana 2007 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=152 https://fedorani.ni.ac.rs/fedora/get/o:698/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533068182 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:157 2015-10-15T00:00:00Z 2

Glikemijski indeks namirnica i glikemijsko opterećenje kao faktori rizika za ishemijsku bolest srca : doktorska disertacija Nikolić, Maja D. Glikemijsko opterećenje U osnovi većine kardiovaskularnih bolesti je ateroskleroza , koja ugrožava srce i dovodi do razvoja ishemijske bolesti srca (IBS). U ukupnom morbiditetu kardiovaskularnih bolesti IBS učestvuje sa preko 40 %, a čak 56% našeg stanovništva završi život usled nekog kardiovaskularnog obolenja. Medju stanovništvom mladjim od 60 godina za čak 40 % je fatalna neko od kardiovaskularnih oboljenja prestana, a Srbija se nalazi u grupi zemalja sa relativno visokim rizikom umiranja od koronarne bolesti kod osoba oba pola u uzrastu od 40 do 49 godina (Vukotić, Nedeljković, 1994.; Ostojić i sar, 2002.). Ishemijska bolest srca je značajan uzrok invalidnosti, gubitka radne sposobnosti, prevremene smrtnosti i sve većih cena zdravstvenih usluga, posebno u zemljama sa niskim prirodnim priraštajem, u kojima dominira starije stanovništvo. Zbog velikog socijalno medicinskog značaja IBS, mnogobrojna istraživanja u svetu i kod nas bila su usmerena na sprečavanje, rano otkrivanje ili suzbijanje jednog ili više faktora rizika za ishemijsku bolest srca Univerzitet u Nišu Medicinski fakultet Kostić, Živka Mitrović, Radunka Ilić, Stevan Mitić-Zlatković, Marina Petrović, Branislav 2004 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=157 https://fedorani.ni.ac.rs/fedora/get/o:699/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533036438 sr Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)

oai:eteze.ni.ac.rs:158 2015-10-15T00:00:00Z 2

Primene metode inverzne poljske notacije i interpolacije u simboličkim izračunavanjima: doktorska disertacija Krtolica, Predrag V. Simbolička izračunavanja Ova doktorska disertacija sadrži opis originalne metode za simbolička izračunavanja, zasnovane na inverznoj poljskoj notaciji. Opisana metoda je primenjena na niz problema iz različitih oblasti. Metod inverzne poljske notacije opisan u ovoj disertaciji omogućuje obavljanje simboličkih manipulacija nad različitm tipovima izraza. Pri tome su izbegnute dinamičke strukture podataka, kao što su povezane liste ili stabla, već se manipulacija obavlja direktno nad statičkim nizovima koji predstavljaju izraze u postfiksnoj notaciji. Svakako da dinamičke strukture podataka omogućiju efikasno korišćenje memorije, ali smo “premošćavanjem” ovih faza dobili na jednostavnosti programiranja i brzini izvršenja. Problem utroška memorije, karakterističan za simbolička izračnavanja, uglavnom je uspešno prebrodjen. Univerzitet u Nišu Prirodno-matematički fakultet Stanimirović, Predrag 2003 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=158 https://fedorani.ni.ac.rs/fedora/get/o:700/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/532588694 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:159 2015-10-15T00:00:00Z 2

Izračunavanje generalisanih inverza : doktorska disertacija Tasić, Milan B. Generalisani inverzi Moj cilj nije bio da ispitujem implementaciju svih poznatih metoda za izračunavanje generalisanih metoda. Takođe mi nije bio cilj da poredim direktne i iterativne metode. Ja sam proučavao pojavu problema povećanje broja operacija u pokretnom zarezu, tokom iteracije, prouzrokovane ponovnim izračunaranjem pojedinih izraza, u numeričkim izračunavanjima pseudoinverza, kao i vezu proceduralnih i neproceduralnih programskih jezika i njihovu mogućnost u uzračunavanju generalisanih inverza. Predložio sam nove metode i nove algoritme, kao i modifikacije postojećih metoda i algoritama, koji rešavaju pomenute probleme. Sve je bazirano na mogućnostima paketa MATHEMATICA kao tipičnog primera programskog paketa za simboličko izračunavanje, i paketa DELPHI kao predstavnika proceduralnih programskih jezika. Metodi i algoritmi koje sam predložio implementirani su i testirani na numeričkim i racionalnim matricama, polinomijalnim matricama, retkoposednutim matricama i na bazama podataka. Oni su primenljivi na sve proceduralne programske jezike. Univerzitet u Nišu Prirodno-matematički fakultet Stanimirović, Predrag S. 2003 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=159 https://fedorani.ni.ac.rs/fedora/get/o:701/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533043350 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:160 2015-10-15T00:00:00Z 2

Povratno mešanje tečne faze i kinetika procesa alkoholne fermentacije u trofaznom bioreaktoru sa vibracionom mešalicom : doktorska disertacija Nikolić, Ljubiša B. Bioreaktori In this paper, the influence of liquid and gas flow rates, vibration intensity, and solid phase volume fraction on the axial mixing of the liquid phase in axial direction of reciprocating plate columns with different geometry (columns RPC1 and RPC2: inner column diameter 2.54 and 9.2 cm, working height 173 and 86 cm, number of perforated plates 65 and 15, and fractional free area 51 and 45.4 %, respectively) was investigated. The tap water flowing down (superficial velocity: up to 0.9 cm/s), air (superficial velocity to 1.5 cm/s) and the polypropylene spheres (diameter 8.3 mm, density 890 kg/m3, ratio up to 8.43 %) were used as the liquid, gas and solid phase, respectively. To study the axial dispersion (axial mixing) the resident-time distribution function was used, which was determined by the pulse input method with sorbic acid used as a tracer (tracer concentration was measured at the column outlet). Univerzitet u Nišu Tehnološki fakultet Veljković, Vlada Skala, Dejan Lazić, Miodrag 2003 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=160 https://fedorani.ni.ac.rs/fedora/get/o:702/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/26002959 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:166 2015-10-15T00:00:00Z 2

Sinteza i karakterizacija alicina, njegovih derivata i inkluzionih kompleksa : doktorska disertacija Nikolić, Vesna D. allicin, ajoene, vinyldithiin, molecule inclusion complexes, β-cyclodextrin, urea, microbiological studies, kinetics, kinetic parameters, mechanism of synthesis The main carriers of the pharmacological activity of garlic (Allium sativum L.) are organosulfur compounds, the most important being allicin (diallyl thiosulfinate). Allicin has a wide range of antibacterial and antifungal effects. It shows significant antioxidative and antitumor effect. The organic molecule is very unstable and depending on the external factors it is transformed to pharmacologically active derivatives. The most important pharmacologically active allicin derivatives are ajoenes and vinyldithiins. They take part in the inhibition of the thrombocyte aggregation, in the regulation of systolic and diastolic blood pressure, reduce the triglyceride and phospholipid levels, show diuretic, antimicrobial, fibrinolytic and vasodilative effect. Therefore, they are of great importance for the pharmaceutical industry. In this dissertation the kinetics of synthesis were studied, the optimal kinetic parameters determined, and defined the mechanism of synthesis of allicin and its derivatives. For their stabilization, allicin complexes were synthesized with β-cyclodextrin and urea as inclusion complexes. The physical and chemical characterization of the synthesized compounds was done by up to date analysis methods. The microbiological studies results were used to determine the microbiological activities of the synthesized compounds. The results obtained in this dissertation present a scientific contribution to the research of new pharmacologically active compounds that might, in the near future, find significant application in the pharmaceutical industry. Univerzitet u Nišu Tehnološki fakultet Stanković, Mihajlo Cvetković, Dragan Palić, Radosav Kapor, Agneš Cekić, Milorad 2003 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=166 https://fedorani.ni.ac.rs/fedora/get/o:703/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/25693455 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:168 2015-10-15T00:00:00Z 2

Perspektive i mogući pravci razvoja finansijskog tržišta s osvrtom na Jugoslaviju : doktorska disertacija Đurović-Todorović, Jadranka The transformation of national segmented financial markets into integrated parts of the global financial markets involves complex cross-border and cross-sectoral integration in which capital movements and financial services are key determinants. The corporate sector plays a major role in this process. The national financial market is a part of the national financial system. The basic function of the financial system is to transfer loanable funds from lenders (savins-surplus units) to borrowers (savings deficit units). In a situation where there are “well-functioning” financial markets, both lenders and borrowers in the markets made better off as a result of the existence of the markets, because lenders can indirectly invest in productive opportunities and get a return on their investment, and borrowers can undertake the investment. The flow of funds can be direct finance, as opposed to indirect finance whereby lenders channel their funds to ultimate borrowers via financial intermediaries. In this second case, savers may make deposit in saving of commercial banks, or they may buy secondary financial instruments issued by financial institutions. Univerzitet u Nišu Ekonomski fakultet Jovanović, Miodrag 2001 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=168 https://fedorani.ni.ac.rs/fedora/get/o:704/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/531355798 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:172 2015-10-15T00:00:00Z 2

Uopšteni inverzi proizvoda operatora : doktorska disertacija Dinčić, Nebojša Č., 1983- U ovoj disertaciji izloženi su originalni rezultati koji se mogu podeliti u dve celine. Najpre se na dva različita načina uvodi razlaganje elemenata iz klase kvadratnih singularnih kompleksnih matrica indukovano uopštenim inverzima, koje se potom koristi u konstruktivnom dokazu Hartove teoreme. Narednu celinu čine rezultati koji se odnose na razne zakone obrnutog redosleda za Mur-Penrouzov inverz proizvoda dva ili više ograničenih operatora na Hilbertovim prostorima. Ispitivani su uslovi pod kojima oni važe, relacije među njima kao i razni identiteti povezani sa zakonima obrnutog redosleda. Popravljeni su rezultati koji važe za kompleksne matrice, s tim što se pri dokazivanju koristi metod operatorskih matrica u odnosu na odgovarajuća razlaganja prostora, umesto metoda matričnih rangova koji je ovde neprimenljiv. Univerzitet u Nišu Prirodno-matematički fakultet Đorđević, Dragan S. 2011 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=172 https://fedorani.ni.ac.rs/fedora/get/o:705/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024110057 sr Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)

oai:eteze.ni.ac.rs:175 2015-10-15T00:00:00Z 2

Ekstremalni problemi i algoritmi za grafovske invarijante bazirane na sopstvenim vrednostima i rastojanjima : doktorska disertacija Ilić, Aleksandar Teorija grafova U ovoj disertaciji grafovi se izučavaju koristeći invarijante bazirane na sopstvenim vrednostima matrice susedstva, Laplasove matrice i matrice rastojanja. Spektri grafova imaju značajne primene kod pretraživanja Interneta, u multiprocesorskim i socijalnim mrežama, u ekonomiji itd. Topološki indeksi su veoma zastupljeni u matematičkoj hemiji, i u radu se prikazuju neke modifikacije grafovske energije i Wienerovog indeksa. U disertaciji se analiziraju Laplasovi koeficijenti i modifikovana Laplasova energija, spektralni radijus matrice rastojanja, energija integralnih cirkulantnih grafova, ekstremalne osobine Estradinog indeksa, stepen-rastojanje invarijanta kod parcijalnih Hemingovih grafova, uvodi se novi jako diskriminativni topološki indeks i prikazuju algoritmi za konstrukciju hamiltonovih grafova sa ograničenjima. Disertacija predstavlja značajan doprinos u izučavanju grafovskih invarijanti koje su bazirane na sopstvenim vrednostima i rastojanjima, sa primenama u kompjuterskim naukama i hemiji Univerzitet u Nišu Prirodno-matematički fakultet Stevanović, Dragan, 1974- Simić, Slobodan, 1948- Gutman, Ivan, 1948- Urošević, Dragan Stanimirović, Predrag, 1959- 2010 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=175 https://fedorani.ni.ac.rs/fedora/get/o:706/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024105705 sr Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)

oai:eteze.ni.ac.rs:180 2015-10-15T00:00:00Z 2

Kinetika mikrotalasne ekstrakcije i karakterizacija bioaktivnih komponenti iz lovor višnje (Prunus laurocerasus L.) : doktorska disertacija Karabegović, Ivana Lovor višnja, Eterična ulja The subject of the doctoral dissertation was the kinetics and the mechanism of the microwave extraction of the cherry laurel (Prunus Laurocerasus L.) leaves, fruits and seeds under different operating conditions, as well as the mechanisms of isolating the essential oil from the leaves (classical hydrodistillation, hydrodistillation, and solvent free distillation under the influence of the microwaves). Solvents of different polarity (water, methanol, 2-propanol) were used for the extraction of the leaves and fruits, whereas n-hexane and system n-hexane:water for the extraction of the seeds. Univerzitet u Nišu Tehnološki fakultet Lazić, Miodrag. 1953- 2011 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=180 https://fedorani.ni.ac.rs/fedora/get/o:707/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/38149135 sr Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)

oai:eteze.ni.ac.rs:181 2015-10-15T00:00:00Z 2

Prilog razvoju metode za valorizaciju akustičke emisije izvora buke dvomiktofonskom procedurom merenja intenziteta zvuka u realnim uslovima : doktorska disertacija Praščević, Momir Izvori buke The primary parameter used to describe and declare the noise source emission - the emission sound pressure level is defined as sound pressure level under free field condition at the specified position that depends on the type and character of noise source. In according to European directives and international standards related to noise sources, each producer of machines, devices and equipment has to declare the sound power level of his products, if the emission sound pressure level exceeds 85dB(A). Therefore, the emission sound pressure level becomes a parameter which must be determined and whose value assigns the necessity of determination of other acoustical quantities aimed to define noise source emission. Univerzitet u Nišu Fakultet zaštite na radu Cvetković, Dragan 2004 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=181 https://fedorani.ni.ac.rs/fedora/get/o:708/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/532554902 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:188 2015-10-15T00:00:00Z 2

Stambena arhitektura Niša u pokretu Moderna između dva svetska rata. Keković, Aleksandar Arhitektura, Niš, Moderna Vremenska distanca od gotovo jednog veka od pojave prvih objekata Moderne i osamdesetak godina od izgradnje prvih objekata modernističkog pokreta u Nišu, predstavljaju dovoljno dug istorijski period da se izvrši objektivna i kvalitetna valorizacija doprinosa i uticaja koji je ovaj pravac u arhitekturi izvršio na stvaranje urbane matrice Niša. Postavši banovinski centar, grad se ubrzano izgrađuje sledeći obrasce i uticaje koji su stizali iz Evrope, ali ponajviše iz prestonice - Beograda. Moderna, kao funkcionalan arhitektonski izraz bez dekorativnih elemenata, odnosi prevagu u Nišu početkom 30-ih godina prošlog veka, pa je sve do Drugog svetskog rata ona dominantan arhitektonski obrazac koji arhitekti koriste. Na osnovu sprovedenog istraživanja u doktoratu navode se bitne karakteristike niške Moderne na planu Tipologije, Urbanog statusa, Funkcije i Oblikovanja. Univerzitet u Nišu Građevinsko-arhitektonski fakultet Anđelković, Mirjana Marušić, Darko Mitković, Petar 2008 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=188 https://fedorani.ni.ac.rs/fedora/get/o:712/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/ sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:764 2015-10-15T00:00:00Z 2

Tehnički pokazatelji za ocenu stanja i predlog mera za unapređenje uspešnosti funkcionisanja manjih vodovodnih sistema u Republici Srbiji : doktorska disertacija Technical performance indicators in water supply system and development of technical measures for performance improvement in small water supply system in Serbia Radivojević, Dragan Vodovodni sistemi, Voda,Vodosnabdevanje In this study the initial prototype of decision support system is presented, which is in permanent development, with a description of the tasks and objectives to be met. Its components and importance of each are shown. The goal is the transformation of the prototype into a integral system to deal with data base system, the knowledge baze, with the numerical simulation of the system and display the results using GIS technology, with the aim of testing the effects of planned actions prior to implementation of the system. Perfomance analysis of water supply systems in Serbia have shown the applicability of the IWA methodology and its adoption is recommended, and systematic work to modernize water supply systems and the introduction of active management. The performances of Serbian water supply systems are unsatisfactory, this problem is very difficult and should be one of the priority tasks of national development programs. There is a case study of water supply in Pirot perfomances; results presented have proven IWA methodology technical indicators impartiality. Well calibrated hydraulic model has been used to simulate the effect of system zoning and the introduction of pressure control, proving that significant cost savings can be achieved without costly reconstruction. Achieved financial savings can be further used to continue to invest in the development of all components of the program for the integrated management system, billing, losses and consumption. Results and experience presented can be a valuable basis and support for water supply systems in Serbia, especially smaller ones, which in addition to small budgets often have problems with excessive loss of water, lack of compentent staff and understanding of issues outside the company. Univerzitet u Nišu Građevinsko-arhitektonski fakultet Aranđelović, Dragan Ivetić, Marko. 1952- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=764 https://fedorani.ni.ac.rs/fedora/get/o:774/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533532822 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:801 2015-10-15T00:00:00Z 2

Prilog modelovanju uzemljivačkih sistema u prisustvu polusferične i cilindrične nehomogenosti tla : doktorska disertacija Cvetković Nenad N., 1970 Uzemljivački sistem, Nehomogenost, Elektromagnetno polje, Numerički metodi, Grinova funkcija The influence of the semi-spherically and cylindrically shaped inhomogeneity on grounding systems in quasi-stationary regime is analyzed in this Ph. D. Thesis.Such inhomogeneities are present in practice and that is the reason for importance of estimating their influence on grounding systems. These systems are significant part of many technical-technology systems, power facilities, telecommunication systems or lightning protection systems. According to the author's best knowledge, not too many of papers had semi-apherical or cylindrical inhomogeneities as an object of research, especially with the approach applied in this paper, although there have been plenty of works published in previous decades dealing with grounding systems'analysis. Univerzitet u Nišu Elektronski fakultet Rančić, Predrag 2008 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=801 https://fedorani.ni.ac.rs/fedora/get/o:779/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533498006 sr Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)

oai:eteze.ni.ac.rs:802 2015-10-15T00:00:00Z 2

Komparativna klinička, imunološka, citogenetska i kariometrijska analiza akutnih leukemija : doktorska disertacija Comparative clinic, immunologic, cytogenetic and karyometric analysis of acute leukemias Govedarović, Nenad, 1965- Akutna mijeloidna leukemija, Citodijagnostika Acute myeloid leukemia (AML) is a malignant disease with fulminant course, which results in a high percentage of patients remaining unfavourable. The aim of our researche is to define potentially new prognostic factors and to campare them with standard, well established, prognostic factors in AML. Study group included 123 newly diagnosed patients, with mean age about 65yr., with diagnosis AML Mo-M5, according to FAB classification. After diagnosis, all patients underwent karyometricanalyses (eg. measure of leukemic blast nuclei parameters), convenctional karyotype analysis, molecular analyses of FLT3 ITD mutation, as well as immunofenotype analisis by flow cytometry. According to results, it can be concluded that the main adverse actors in AML are: advanced age of patient, leucopenia or white blood cells count higher than 100000 x 10 on 9th/1 presence of FLT3 ITD mutation and higher siye of myeloblast's nuclei. Univerzitet u Nišu Medicinski fakultet Mihailović, Dragan Mačukanović, Lana Popović, Stevan, 1955- 2011 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=802 https://fedorani.ni.ac.rs/fedora/get/o:780/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024085741 sr Autorstvo-Bez prerade 3.0 Srbija (CC BY-ND 3.0)

oai:eteze.ni.ac.rs:812 2015-10-15T00:00:00Z 2

Projektovanje parcijalno visokopouzdanih procesorskih polja : doktorska disertacija Ćirić Vladimir 1977- Računarska arhitektura, Procesorska polja, DSP algoritmi, sistolička polja, semi-sistolička polja U cilju smanjenja uticaja defekta u procesu proizvodnje, a samim tim i povećanja prinosa, u ovom radu predložena je primena metoda za povećanje pouzdanosti dela arhitekture, označenog kao deo od najvećeg značaja za datu primenu. Za razliku od ET koncepta, kod koga je projektant svestan mogućnosti postojanja defekta, zna njegovu poziciju i uticaj, i ne menja svojstva arhitekture kako bi otklonio posledice defekta, kod predložene tehnike parcijalnog povećanja pouzdanosti projektant na sistematski način određuje uticaje defekta na delove arhitekture i određuje koje delove treba projektovati kao visoko pouzdane. Ovakvim kompromisom dveju tehnika uveden je novi stepen slobode kod projektovanja sistema, koji rezultuje arhitekturom parcijalno tolerantnom na defekte. Univerzitet u Nišu Elektronski fakultet Milentijević, Ivan 2010 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=812 https://fedorani.ni.ac.rs/fedora/get/o:788/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533499286 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:814 2015-10-15T00:00:00Z 2

Novi topološki pristup simboličkoj analizi elektronskih polja : doktorska disertacija A new original method for symbolic analysis of electronic circuits Đorđević Srđan 1968- Elektronska kola, Mikroelektronika The main motivation of this dissertation is to contribute to the development of symbolic algebra in scope of electronic circuits analysis. A new original method for symbolic analysis of electronic circuits has been developed and implemented. In contrary to other commonly used methods for symbolic circuit analysis the specificity of this method lies in the fact that it is entirely topology oriented. The proposed procedure provides exact symbolic network function purely by inspecting the topology of the circuit. The method introduces a graph representation of the factorization process, that is constructed directly from a given circuit description. The dissertation is a synthesis of author's published results as well as more recent unpublished material that has emerged during the development of the dissertation. Symbolic analysis is a procedure that generates a circuit function in the form of algebraic expressions such that some or all of the circuit elements and complex frequency are represented by symbolic variables. Unlike the numerical circuit analysis, which provides only quantitative information, symbolic circuit analysis (SCA) provides information of the qualitative contribution of each circuit parameter to the network function. Practically, SCA is mutually complementary to the numerical based electronic circuit analysis. The main drawback of SCA is exponential growth of circuit function intricacy, memory and time requirements with the circuit complexity. Therefore, a hierarchical approach is advisable for treating complex circuits. The technique of hierarchical decomposition of complex circuits results with compact symbolic expressions in nested form. Several methods have been developed to generate nested symbolic expressions of the circuit function using hierarchical decomposition. Some of these methods are graph based and some are matrix based. The most of the modern procedures for symbolic analysis are matrix based. A good representative to the efforts that SCA community spends in this direction is Determinant Decision Diagram method (DDD). Recently presented results proved its efficiency. Univerzitet u Nišu Elektronski fakultet Predrag Petković Vančo Litovski Branimir Reljin Milutin Jevtić Dragiša Milovanović 2010 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=814 https://fedorani.ni.ac.rs/fedora/get/o:791/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533499030 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:818 2015-10-15T00:00:00Z 2

Patofiziološki aspekti glomerulskih i tubulointesticijskih bubrežnih oboljenja: proteomski pristup : doktorska disertacija PATHOPHYSIOLOGY OF GLOMERULAR AND TUBULOINTERSTITIAL KIDNEY DISEASES: PROTEOMIC APPROACH Pešić, Ivana Bubrežna oboljenja, Patofiziologija Introduction: Kidney diseases are the biggest health problem nowadays. Endemic nephropathy (EN) is a chronic tubulointerstitial kidney disease, undetectable at the beginning and with slow development to terminal renal failure. The real cause of the disease is still not known. Although the importance of inheritance is underlined, the effects of environmental factors (aristolochic acid, a mycotoxin) and the presence of disorders of the immune system are more likely to be involved in disease pathway. Aim: We aimed to establish qualitative and quantitative differences of proteins in urine of patients with the endemic nephropathy, diabetic nephropathy, acute prerenal kidney injury, and their importance in the diagnostics. The acute and chronic effects of aristolochic acid 1 and ochratoxin A on tubulocytes are important for establishing the mechanisms of kidney damage and the potential biomarkers. Methods: Proteomic technology was used, and the results were confirmed by Western blot, dot blot, immunofluoroscence and immunohistochemisry analyses of cells and tissue samples. Importance: The use of proteomic technologies of urine proteins in patients and healthy controls gives a new data for the identification of diagnostic and prognostic markers of kidney damage. This study shows the presence of significant differences in the proteins of the respondents, which can be used as diagnostic and differential diagnostic parameters. Study of toxic effects of aristolochic acid 1 and ochratoxin A permited a better understanding of the mechanisms of kidney disease, but first of all, a better expanation of molecular pathway in the initiation and during development of endemic nephropathy and associated urothelial cancer. Univerzitet u Nišu Medicinski fakultet Stefanović, Vladislav Bojanić, Vladmila Stojmenov, Tatjana Jeftović Miler, Gerhard A. Dihazi, Hasan 2011 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=818 https://fedorani.ni.ac.rs/fedora/get/o:793/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024119277 sr Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)

oai:eteze.ni.ac.rs:877 2015-10-15T00:00:00Z 2

Upravljanje performansama poslovnih procesa u funkciji povećanja efikasnosti preduzeća : doktorska disertacija MANAGING BUSINESS PROCESS PERFORMANCE IN FUNCTION OF INCREASING EFFICIENCY OF ENTERPRISE Kahrović, Ernad Upravljanje preduzećem A competitive game in the knowledge economy differs in several aspects from the business and market competition in the industrial era. These are the increased relevance of intellectual capital in creating values, the necessity of understanding the needs of key stakeholders, the need to increase the volume and quality of services provided to consumers, enterprises’ necessity to increase the flexibility to the changes in the environment, efficient application of information technology and others. Process-oriented approach in managing the company emerges as a result of these and many other changes in the knowledge economy. The main characteristic of process-oriented enterprise is flexibility, reflected in the possibility of quick and adequate response to changes in the environment. Process-oriented company is being formed through transformation of a traditional (functional) structure into a new one, so as processes are being used as the basis for grouping tasks instead of functions. This means that jobs are not grouped according to their similarity or resemblance, as in the functional approach, but to their connection to the appropriate process. In this way, instead of classical organizational units (procurement, production, sales, finance, etc.), teams are being emphasized, containing all of those tasks and activities, being within the aim of realization of the specific process. A company with a previously arranged hierarchical system of functional units becomes flatter, with fewer levels of management, and autonomous teams perform certain activities and processes from their beginning to the final ones. Finding an adequate way of performance management in process-oriented enterprise is the focus of the above concept. A management framework shall be developed in the paper, consisting of four phases, titled as: planning, measuring, analyzing and improving of business process performances. Planning is the first phase involving definition of the target (desired) performance of the process being relevant in gaining both in the realization of a strategy / performance improvement program process and strategy for the company, as a whole. On the other hand, the quality of measurements and established system of performance measurement process depend on the quality of managerial decisions regarding business processes. After the measuring process, there is a process of analysis of performances management and reporting this structure on them. The process of performance management process is being finalized in determination of measures, actions, programs and initiatives by the company's management, necessary to improve process performance, since they are being manifested themselves in the vital financial performance of companies and their impact on its competitiveness. In addition, process-oriented enterprise, more accurately, the improved performance of the process of supplying the necessary inputs, creation and production of products, sales and another marketing activities, delivering products and customer service processes, affect the economic performance, investment performance and other companies’ performances, like the amount and quality of products, company’s income, expenses, profits, efficiency and others. By reviewing of recent research results, there is an indication that most of the resources associated with process-oriented enterprise performance belong to the literature that is not based on adequate data and empirical tests. In this regard, as a part of a doctoral dissertation, the results of empirical research shall be presented to be conducted on a sample of companies from Serbia. The purpose of this study shall be identifying the possibilities of applying of the process approach within the companies in Serbia, as well as, analyzing the presence and effects of the implementation of the concept of performance management of business processes in them. Univerzitet u Nišu Ekonomski fakultet Krstić, Bojan Babić, Verica, 1955- Sekulić, Vesna, 1968- 2012 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=877 https://fedorani.ni.ac.rs/fedora/get/o:798/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533430934 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:937 2015-10-15T00:00:00Z 2

Matematičko modeliranje i optimizacija procesa laserskog sečenja primenom metoda veštačke inteligencije : doktorska disertacija MATHEMATICAL MODELING AND OPTIMIZATION OF LASER CUTTING PROCESS USING ARTIFICIAL INTELLIGENCE METHODS Madić, Miloš, 1981 Lasersko sečenje, Taguči metod, modeliranje, optimizacija Laser cutting is one of more attractive non-conventional machining technologies which is being increasingly used in industry due to its efficiency. Laser cutting is based on the use of highly concentrated light energy, obtained by laser irradiation, for materials processing by melting or evaporation. Since it is desirable to remove the molten and evaporated material from the cutting zone as soon as possible, laser cutting is performed with a coaxial jet of an assist gas. From the technological point of view, laser cutting is a very complex process of interactions between the laser beam, assist gas and workpiece material, whose performances are influenced by a number of factors. Insufficient knowledge of the process as well as a lack of reliable and practical data about influential factors leads to underutilization of laser cutting technology with respect to the possibilities that it provides, but also to the fact that the cut quality does not satisfy users. In order to ensure achievement of the required cut quality, cost reduction and increase of productivity, it is necessary to quantify the relationships between process factors and process performances through the mathematical modeling. On the basis of developed relationships it is possible to perform a detailed analysis of the influence of process factors on process performances, identify near optimal factor values and control the process of laser cutting so as to improve the efficiency and cut quality. This paper presents the results of experimental studies carried out with the objective of modeling and optimization of laser cutting process i.e. assessment of process factors effects and application of obtained results for control of laser cutting process in order to increase the cut quality obtained in CO2 laser nitrogen cutting of stainless steel. Based on data from experimental studies carried out by using Taguchi’s orthogonal array, mathematical models relating cut quality characteristics and process factors such as laser power, cutting speed, assist gas pressure and focus position were developed. Mathematical modeling has been carried out using artificial neural networks, whereby the training of artificial neural networks was conducted by using Levenberg-Marquardt algorithm. On the basis of developed mathematical relationship between the cut quality characteristics and process factors, single and multi objective optimization of laser cutting was enabled. For the purpose of optimization two approaches were applied. The first approach is based on the integration of mathematical models created by artificial neural networks and meta-heuristic optimization methods. The second approach, which is aimed at determining the near optimal values of process factors in a way that the laser cutting process is robust to different causes of variation, was based on the application of Taguchi’s optimization method. In order to validate optimization solutions that were previously determined using different optimization methods, solve multi-criteria optimization problems and “off-line” control of laser cutting process, in the dissertation developed software prototype was presented. The modeling and optimization methodology presented in the dissertation and its implementation through the development of application software for industrial use, can raise planning of laser cutting process to a higher level and make process more economical and productive. Univerzitet u Nišu Mašinski fakultet Radovanović, Miroslav Marinković, Velibor Manić, Miodrag Nedić, Bogdan. 1959- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=937 https://fedorani.ni.ac.rs/fedora/get/o:800/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533541782 sr Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)

oai:eteze.ni.ac.rs:938 2015-10-15T00:00:00Z 2

Oscilacije i stabilnost sistema elastično povezanih Timošenkovih greda : doktorska disertacija Vibration and stability of systems of elastically connected Timoshenko beams Stojanović, Vladimir Timošenkove grede The presented work consists of seven parts which are separately formed by chapters. The first chapter relates to the introductory discussion and review of previous research in the theory of elastic and related damaged structures. It is one of the ways to perform partial differential equations of motion of mechanical systems and provides a basic overview of the methods used. Chapters 2-6 are devoted to the analysis of linear elastic oscillations. The seventh chapter is devoted to geometric nonlinear oscillations of damaged beams using the new finite element method. Free oscillations and static stability of two elastically connected beams are considered in Chapter 2. At various examples it is shown analytically obtained results and impacts of some mechanical parameters of the system to the natural frequency and amplitudes. Verification of the obtained analytical results is shown by comparison with results of the existed classical models. New scientific contribution in this chapter is formulation of the new double-beam model described with new derived equations of motion with rotational inertia effects and with inertia of rotation with transverse shear (Timoshenko’s model, Reddy - Bickford 's model). It is formulized the static stability conditions of the two elastically connected beams of different types with analytical expressions for the values of critical forces. Numerical experiments confirmed the validity of the analytical results obtained by comparing the results of the models existing in the literature. From chapter 2 it can be concluded that the effects of rotational inertia and transverse shear must be taken into account in the model of thick beams because errors that occur by ignoring them increase with the mode of vibration. Chapter 3 presents the solution for forced vibrations of two elastically connected beams of Rayleigh’s, Timoshenko’s and Reddy – Bickford’s type under the influence of axial force. Scientific contribution is presented analytical solutions for forms of three types of forced vibration - Harmonic arbitrarily continuous excitation, the continuous uniform harmonic excitation and harmonic concentrated excitation. Analytical solutions were obtained by using the modal analysis method. The chapter also presents the analytical solutions of forced vibration for the case of harmonic excitation effects are concentrated on one of the beams under effect of compressive axial forces. Based on the results derived in this chapter, it can be made conclusion that the differences in the approximations of the solutions depending of the used model gave a good solutions just in case of Timoshenko and Reddy-Bickford theory for thick beams in higher modes. Classical theories don’t give a quite good results. Chapter 4 considers the static stability of the elastically connected two and three beams and single beam on elastic foundation. It is derived a new set of partial differential equations for static analysis of deflections and critical buckling force of the complex mechanical systems. It is analytically determined critical buckling force for each system individually. It is concluded that the system is the most stable in the case of one beam on elastic foundation. Chapters 5 and 6 analyzed free vibration of more elastically connected beams of Timoshenko and Reddy-Bickford's type on elastic foundation under the influence of axial forces. Analytical solutions for the natural frequencies and the critical force are determined by trigonometric method and verified numerically. Chapter 7 presents geometrically nonlinear forced vibrations of damaged Timoshenko beams. In the study it is developed new p-version of finite element method for damaged beams. The advantage of the new method is compared with the traditional method and provides better approximations of solutions with a small number of degrees of freedom used in numerical analysis. Scientific contribution is in two topics-computational mechanics and non-linear vibrations of beams. It is concluded that traditional method can’t give good approximations of solutions in the case of very small width of the damage. This benefit is also shown in comparison with obtained results in the commercial software Ansys. A new p-version finite element is suggested to deal with geometrically non-linear vibrations of damaged Timoshenko beams. The novelty of the p-element comes from the use of new displacement shape functions, which are function of the damage location and, therefore, provide for more efficient models, where accuracy is improved at lower computational cost. In numerical tests in the linear regime, coupling between cross sectional rotation and longitudinal vibrations is discovered, with longitudinal displacements suddenly changing direction at the damage location and with a peculiar change in the cross section rotation at the same place. Geometrically nonlinear, forced vibrations are then investigated in the time domain using Newmark’s method and further couplings between displacement components are found. Univerzitet u Nišu Mašinski fakultet Kozić, Predrag 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=938 https://fedorani.ni.ac.rs/fedora/get/o:801/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533542038 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:939 2015-10-15T00:00:00Z 2

Regenerativni potencijal masnog tkiva u nadoknadi defekata kostiju na eksperimentalnom modelu kalvarije kunića : doktorska disertacija Vučković, Ivica, 1961- Kosti Repair of bone defects that arise as a result of trauma, tumor resection, or congenital anomalies is still a big challenge for surgeons. More recently, tissue engineering (TE) based on the use of mesenchymal stem cells (MSCs) is an approach that seems promising in the regeneration of bone. Particularly rich source of MSCs is adipose tissue. Current approach of using mesenchymal stem cells from adipose tissue (ADSCs) and stem cells in general, in the tissue engineering and regenerative purposes is characterized by the expansion of these cells in vitro, and then planting of cells on carriers and their implantation. Since it has been shown that an environment rich in hydroxyapatite, as well as a natural bone, can be a good microenvironment for differentiation of ADSC into osteoblasts it was assumed that those cells in such an environment in the body can provide conditions for the differentiation into osteogenic cells. The aim of this study was to investigate the role of adipose tissue in regeneration of bone defects in the rabbit calvaria defect model in two ways, by isolating mesenchymal stem cell fraction and application without precultivation in vitro, and the application of whole adipose tissue cut into small pieces. Also the aim was to examine the role of commercial bone deputy (Bio-Oss) and nanomaterial CP-PLGA (calcium phosphate-poly-DL-lactide-co-glycolide) in the function of different cell carriers and tissues. The research included twenty experimental animals separated into four groups of five animals in each. In the first and the third group Bio-Oss (bovine bone mineral matrix) was used as a carrier of isolated cells and in the second and the fourth group nanomaterial CPPLGA was used as a carrier. On calvaria of each rabbit five defects were made from which four were filled with prepared grafts and implants and the fifth defect remained unfilled and represented a spontaneous regeneration. The process of creating bone tissue and bone density in defects were observed radiographically using MSCT-64 scanner after I, III and VI week of filling defects. Half of the animals (group I and II) were sacrificed after four weeks, and the rest (group III and IV) after eight weeks of filling defects. It was found that the degree of osteogenic process in the tested grafts depends on the type of biomaterial used as a carrier of cells and tissues, as well as biological components that are combined with it. The use of Bio-Oss in the role of the implant eventually leads to the 131 collapse of bone density. If Bio-Oss is used as a carrier in the grafts whose components are fat or whole blood then contributes significantly to the increasing and maintaining bone density. Nanomaterial CP / PLGA proved to be a good carrier for adipose-derived mesenchymal stem cells in regeneration of calvaria. The use of nanomaterials increases bone density only when used as a carrier for the ADSC. Combining fresh non-induced ADSC with nanomaterials in blood clots leading to rapid initiation of bone regeneration. Approach to assisted osteoregeneration which is based on the use of fresh non-induced ADSC has proven to be promising due to the favorable effect on bone regeneration and their simplicity. For the final application of ADSC and adipose tissue in regenerative purposes requires further research in order to improve these processes and optimize them Univerzitet u Nišu Medicinski fakultet Petrović, Dragan Najman, Stevo Jović, Nebojša Višnjić, Milan Petrović, Slađana 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=939 https://fedorani.ni.ac.rs/fedora/get/o:803/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024514541 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:940 2015-10-15T00:00:00Z 2

Protektivni efekti selena i salicilne kiseline kod pacova sa akutnom insuficijencijom bubrega izazvanom gentamicinom : doktorska disertacija PROTECTIVE EFFECTS OF SELENIUM AND SALICYLIC ACID IN GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS Ranđelović, Pavle, 1980 Akutna bubrežna insuficijencija Gentamicin is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. Salicylic acid is a phenolic compound present in plants with free radical-scavenging and iron chelation properties. It is a hydroxyl radical scavenger and can affect the activation of transcription factors. Selenium is a fundamental trace element that plays an important role in a number of physiological processes, including the elimination of reactive oxygen species. The present study was designed to determine the protective effect of selenium and salicylic acid in gentamicin-induced nephrotoxicity in rats. Experiments were done on 64 adult Wistar rats divided into 8 groups of 8 animals each. The control group received only saline (1 ml/day) intraperitoneally (i.p.). Animals in the SE, SAL and SS groups, serving as positive controls, received only selenium (1 mg/kg), salicylic acid (100 mg/kg) and their combination, respectively. The GM group received gentamicin (100 mg/kg) i.p. The GSE group received the same dose of GM and selenium (1 mg/kg) by i.p. injections on a daily basis. The GSAL group received the same dose of GM and salicylic acid (100 mg/kg). The animals in GSS group received gentamicin with selenium and salicylic acid. All groups were treated during 8 consecutive days. Quantitative evaluation of GM-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological, biochemical and morphometric analyses in order to determine potential beneficial effects of selenium or salicylic acid coadministration with GM. Gentamicin was observed to cause a severe nephrotoxicity which was evidenced by an elevation of serum urea and creatinine levels. The significant increases in malondialdehyde levels and protein carbonyl groups indicated that gentamicin-induced tissue injury was mediated through oxidative reactions. Ultrastrucural changes in kidney after gentamicin treatment included enlargement of glomeruli, infiltration of mononuclear cells, rupture of the basal membrane and necrosis of tubular cells. Selenium and salicylic acid administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by gentamicin treatment. The results from our study indicate that selenium and salicylic acid attenuates oxidative-stress associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats. Selenium and salicylic acid pretreatment results in significant reduction of morphological and functional kidney alterations induced by gentamicin. Univerzitet u Nišu Medicinski fakultet Veljković, Slavimir Radenković, Mirjana Stojiljković, Nenad, 1970 Sokolović, Dušan Ivetić, Vesna, 1950 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=940 https://fedorani.ni.ac.rs/fedora/get/o:805/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024539117 sr Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)

oai:eteze.ni.ac.rs:950 2015-10-15T00:00:00Z 2

Farmakokinetička ispitivanja takrolimusa kod pacijenata sa presađenim bubregom : doktorska disertacija Pharmacokinetics analysis of tacrolimus in kidney transplant patients Đorđević, Aleksandra Catić- 1971- Transplantacija bubrega Tacrolimus (Tac) is an effective immunosuppressive drug that represents a part of standard immunosuppressive protocol for kidney transplant patients. Its leading role in the immunosuppressive therapy is based on the proven benefits in the prevention of acute rejection of transplanted kidney and preservation of graft function. Therapeutic monitoring of Tac and appropriate pharmacokinetic approach are particularly important for optimal immunosuppression due to its interindividual variability and low therapeutic index. It is possible to determine the extent and significance of interindividual variability of Tac by pharmacokinetic analysis. It is known that Tac during the long-term use exerts toxic and adverse effects. It is possible to determine the presence of drug interactions and the correlation between concentration of tacrolimus and its side effects by pharmacokinetic analysis of therapeutic and biochemical monitoring data. The aim of our study was to determine the pharmacokinetic parameters of Tac after the first oral dose and their confirmation in steady state. Non-compartment and population pharmacokinetic analysis of Tac was the basis of the research. Our results showed gender differences in the pharmacokinetics of Tac. Therefore, we conducted selective pharmacokinetic approach after first oral dose of Tac and after achieving steady state. In female patients concentration of Tac two hours after oral administration was determined as an indicator of exposure to tacrolimus after initial oral drug administration and after achieving a steady state. In male patients, three-point method (concentrations of Tac 1, 4 and 12 hours after oral administration), provides a good predictability of the total drug exposure. After reaching a steady state, this method can be replaced by measuring the concentration achieved eight hours after drug administration. During the study it was determined a dose dependence and gender difference of the interaction between corticosteroids and tacrolimus. The results of our study showed that the implementation of therapeutic and biochemical monitoring together enable optimal therapeutic effect with minimizing adverse effects of complex immunosuppressive therapy. It was found by population pharmacokinetic analysis that the effects of corticosteroids on Tac concentration stops with prednisolone daily dose reduction to 25mg. The results of our assessment confirm the necessity for development of pharmacokinetic model of tacrolimus in order to implement a rational pharmacotherapy in renal transplantation patients. Univerzitet u Nišu Medicinski fakultet Radovanović, Radmila Veličković- 1961- Mikov, Momir, 1956- Cvetković, Tatjana, Mitić, Branka 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=950 https://fedorani.ni.ac.rs/fedora/get/o:807/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024507885 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1060 2015-10-15T00:00:00Z 2

Ličnost nastavnika i stilovi upravljanja razredom : doktorska disertacija TEACHERS’ PERSONALITY AND CLASSROOM MANAGEMENT STYLES Đigić, Gordana, 1961- Upravljanje razredom, Ličnost nastavnika classroom management This work is concerned with the relation between structural and dinamic personal characteristics of teachers and classroom management styles. Classroom management is related with all teacher’s actions, aimed to create safe and stimulative learning environment, that could be covered by three broad dimensions. The first of them includes teacher's actions related with students' personal growth and establishing of psychological atmosphere in the classroom. The second dimension consists of all that teacher undertakes to ensure the performance of the learning process in the classroom: the use of space, equipment and learning materials, organization of time, the choice of teaching forms, methods and techniques, variety of activities, involvement of students into learning activities and maintenance of their activity during the classes, instructions, learning content structuring. The third dimension is related to procedures that teacher undertakes to establish and maintain discipline in tne classroom. It is clear, therefore, that the concept of classroom management involves a number of roles that a teacher performs working with students, and competences that are necessary for their successful performance, but it is also associated with teachers’ personality characteristics which largely determine the way in which the teacher controls the situation in the classroom, ie. the dominant classroom management style he applies. This paper examines the three styles: interventionist, non-interventionist and interactionist. The first two are located at the ends of the continuum that represents the distribution of power and control over the situation in the classroom between teacher and students. At one end it is a style that is characterized by the complete control of the teacher (interventionist), and at the opposite end of the continuum it is the style of teacher who completely passes responsibility for the situation in the classroom to students (non-interventionist). Between these two extremes it is the interactionist style that implies the distribution of responsibility and of control over the situation in the classroom between teacher and students. Given that classroom management styles are shown as different successful when their effectiveness is measured by the quality of classroom climate and through students’ academic achievement, the question is whether it is possible to identify those personality traits that characterize the profile of teachers who use various styles of classroom management. Therefore, a total of 273 class teachers and subject teachers from several primary schools 265 were examined by Personality Inventory NEO PI-R, Inventory of personal orientation POI, Scale of authoritarian worldview AP 2, and Inventory of classroom management styles ICMS. Also, two independent evaluators observed two classes of each teacher in the sample and, using the Protocol for teachers’ classroom management styles assessment PPSNUR (instrument developed through this research), evaluated the level of expression of each of these three styles and the style that every teacher predominantly uses. Every teacher and all students of visited classes assessed the quality of classroom climate during the lessons held by observed teacher in that class. In order to collect data about the control variables, each teacher completed the questionnaire about demographic variables and the variables related to teacher’s professional status, working motivation, professional development and working environment, and Working climate questionnaire WCQ. The results show that, among the studied variables in the domain of structural and dynamic teachers’ personality traits, the most significant predictor of classroom management styles is one of the two major dimensions of self-actualization, Time competence. Among examined basic personality dimensions, Extraversion, Openness to experience and Agreeableness were identified as significant predictors of teachers’ classroom management styles. In addition to these dimensions, it was shown that teacher’s experience with the quality of the working climate, in terms of the degree of autonomy that he realizes in his work, is important predictor of classroom management styles as well. The research results also confirmed that the interactionist classroom management style is the most effective approach. Both students and teachers were the most satisfied with the quality of classroom climate when the teacher uses it as the predominantly style, ie. when interactionist style is more expressed in his work in the classroom. Also, in comparison with the other two styles, interactionist style is advantageous to improving students’ academic achievement. In addition to shedding light on the very concept of classroom management through the analysis of its relationship with teachers’ personality characteristics and to reconsideration of the effectiveness of various classroom management styles, research results have practical implications, because they suggest the possibility of supporting development of those personal characteristics of future and in-service teachers that could contribute to use interactionist style. Such support could be provided through programs of basic teachers’ education and in-service teachers’ trainings, as well as through establishing appropriate working climate in schools. The final effect would be further improving the quality of education in our schools. Univerzitet u Nišu Filozofski fakultet Stojiljković, Snežana, 1954- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1060 https://fedorani.ni.ac.rs/fedora/get/o:812/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533550742 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1061 2015-10-15T00:00:00Z 2

Polni moral mladih u rodnoj perspektivi : doktorska disertacija Youth Sexual Morality in Gender Perspective Redžić, Saduša Polni moral Sociology associates the existence of double standards of sexual morality with women being the marginalised gender group. Patriarchal tradition and the conversion to Orthodox Christianity (Islam) have contributed to the subordination of women in Serbia, but after World War II, the so-called ‘women issue’ was regulated by law, making a woman formally equal to a man, and guaranteeing and protecting their reproductive rights at the legislative level. We live in a time of rapid and profound social changes, and the assumption in the study is that these changes affect the sexual morality. The question this paper aims to answer is if double standards of sexual morality are still cherished by Serbian youth, despite the efforts to set the same standards for men and women. 386 The research was conducted using deep interviews with students of both sexes, at the Nis Unuversity. We looked for the answers to questions that were asked in the survey, by examining their attitudes about sex and gender socialization, marriage and family, sexual virility and sexual relations. Research has shown that in certain aspects of the sexual moral attitudes of male and female students are different, and not in others. Double standards of sexual morality still exists among some students, and attitudes of some respondents of both sexes indicate their tendency to overcome it. Univerzitet u Nišu Filozofski fakultet Gavrilović, Danijela, 1967- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1061 https://fedorani.ni.ac.rs/fedora/get/o:814/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533550230 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1063 2015-10-15T00:00:00Z 2

Karakteristike ličnosti nastavnika i majki i njihov odnos prema inkluziji dece sa razvojnim smetnjama : doktorska disertacija Stanković-Đorđević, Mirjana Inkluzivno obrazovanje Inklusive Bildung bedeutet die Praxis der Einbeziehung aller Schüler unabhängig von Inclusive education implies the practise of inclusion of all students regardless of their talents, limitations, socio-economic status or backgrounds into regular schools and classrooms where it is possible to meet all their needs. Inclusion is based on the sense of belonging which does not only entail immediate physical propinquity, but also the opportunity for children with different abilities to study, play and work together. The ecosystem approach of the research aims to investigate the network of micro and mezosystemic relationships within which the principles of institutional action mix with a number of various personal equations. By studying the characteristics of the persons central to the success of educational inclusion it was the aim of this research to specify the personality traits of teachers and mothers who encourage the process of inclusion, as well as the factors which can influence the denial of and resistance to it. The most significant contribution of this paper can be preceived in the affrimation of a positive influence of regular education on children with developmental disabilities, as well as on children from regular population. Children with developmental disabilities have a strong sense of belonging to regular schools, while children from regular classrooms show a low level of social distance, which is a direct support for the process of educational inclusion. When it comes to children with developmental disabilities, there are several significant predictors of the sense of belonging to regular schools: - momentary low anxiety of the mothers of children with developmental disabilities - positive attitude of the mothers of children with developmental disabilities towards inclusion - empathy – Fantasy dimension of The Interpersonal Reactivity Index of the mothers of children with developmental disabilities, which is in a negative correlation with the sense of belonging to school - empathy – Role assuming dimension of The Interpersonal Reactivity Index of the mothers of children from regular population, which is in a positive correlation with the sense of belonging to school - general anxiety of the mothers of children with developmental disabilities; the lower general anxiety is, the stronger the sense of belonging to school. Mothers who have a stable personality bring up their children in the spirit of mutual respect and appreciation of diversity. As a result, the children from regular population do not show large social distance from the children with developmental disabilities. More importantly, children with developmental disabilities have a very strong sense of belonging to school and the community, and they do not suffer from secondary effects of disability. School teachers are paradigms that largely influence a sense of belonging to school, as well as intergenerational relations and personal and social values of children with developmental disabilities. The relationship between parents and teachers should involve partnership, a twoway communication, as well as emotional and social support, which should be an imperative in working with children with developmental disabilities and their parents. An important prerequisite of the success of inclusion is the expansion of this process into extracurricular context. Collectivism as a cultural syndrome prevalent in this region implies social decentration, emphasizing collective welfare, concern and respect for our fellow man. These are the foundations upon which the process of inclusion can be constructed with the aim of fulfilling its main purpose – egalitarian cohabitation of all members of society. When it comes to educational inclusion it is very important to become aware of the fact that every school 281 needs to be sufficiently equipped to meet the needs of its students. It is highly probable that different groups of children will achieve different levels of success through various academic, social and affective outcomes. However, the success of inclusion should be measured with the amount of pleasure that all the parties take in carrying out the entire process. Univerzitet u Nišu Filozofski fakultet Todorović, Jelisaveta, 1960- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1063 https://fedorani.ni.ac.rs/fedora/get/o:815/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533456790 sr Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)

oai:eteze.ni.ac.rs:1064 2015-10-15T00:00:00Z 2

Korelati mentalnog zdravlja adolescenata srpske nacionalnosti sa Kosova i Metohije : doktorska disertacija The Corelates of Mental Health of Serbian Adolescents at Kosovo and Metohija Stanojević, Dragana Mentalno zdravlje Mental health is one of the most intrigue concepts in psychology and psychiatry. There is a great number of definitions and models used for better and more precisely explanations and understandings. Present thesis was based on one of the most contemporarily models of mental health – three partite model of positive mental health (Keyes, 2002). According to that model, positive mental health could be understand through three concepts of well-being: emotional, psychological and social, with theirs specific aspects. Main aim of this study was to investigate repeatability of Keyes` model of positive mental health on Serbian adolescents sample, as well as hypothesis about dual-factor model of mental health and mental disease. Besides that, aim of study was also to investigate prevalence of levels of positive mental health, depression and anxiety, and risky behavior at Serbian adolescents in Kosovo and Metohija and Central Serbia. Sample consisted of 816 adolescents, age 17-24, were assigned questionnaires for measuring positive mental health (MHC-LF, Keyes, 2002), depression (Beck et al., 1979), anxiety (Beck et al., 1988), risky behavior (Scaar, 2009), family satisfaction (Antonovsky & Sourani, 1988) and serial questions about general functioning in peers relations, school/faculty etc. Results showed that Keyes` model of positive mental health could be applicable on Serbian adolescent population. Also, dual-factor model of mental health and mental disease showed to be better then model with only one factor, confirming hypothesis that these factors are different but correlated. This research also showed that adolescent from Kosovo and Metohija have lower positive mental health compared to adolescents from Central Serbia. Specifically, in sample from Kosovo and Metohija there was significantly smaller number of respondents with “flourishing” mental health. Respondents from these two groups are not significantly different in prevalence of symptoms of depression and anxiety, as well as in level of risky behavior. In present thesis, theoretical and practical implications, as well as guidelines for future research in this area are discussed. Univerzitet u Nišu Filozofski fakultet Dimitrijević, Bojana, 1961- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1064 https://fedorani.ni.ac.rs/fedora/get/o:816/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533550486 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1076 2015-10-15T00:00:00Z 2

Formiranje urbane strukture i arhitektonskih oblika Caričinog Grada u VI veku : doktorska disertacija FORMATION OF URBAN STRUCTURE AND ARCHITECTONIC FORMS OF THE CARICIN GRAD IN 6TH CENTURY Momčilović-Petronijević, Ana Ranovizantijska nalazišta, Caričin Grad Iustiniana Prima, Justinian Byzantium, Architecture, Urban Structure The results of archeological and architectonic research of Caricin Grad are only partially known to the scientific public in spite of the numerous publications. For this reason, this paper is a way to present the urban structure of the city and its architectonic forms by gathering concise results and analyses of new architectonic field research and of the already published ones as well. The synthesis of new and already known facts and data, provides a more complete and thus clearer picture of the physical structure of this early Byzantine city than the one which exists now. The paper aims towards study of architectonic and urban forms of early Byzantium. The paper provides an analysis of archeological site, Caricin Grad from the viewpoint of urban structure, as well as an analysis of architectonic structures. Also viewed and analyzed were the issues of water supply for the city, and sewage system. The impacts responsible for formation of Caricin Grad in 6th century were analyzed, and also the building method and applied materials, by finding their origin, The building and other influences of Caricin Grad on the development and emergence of sacral architecture and individual forms of public architecture in the immediate vicinity of the city were defined. The paper determined the development of urban and architectonic form of Caricing Grad from founding in the first half of 6th century AD to its disappearance in 7th century AD, historical background of development. The documents on the individual structures of the city and parts of the city were updated, a typological classification (primarily religious) structures was established, and other early Byzantine sites in the vicinity were analyzed and the value of this category of building heritage was determined. The doctoral dissertation research results may serve as a basis for creation of adequate detailed town planning – technical and conservation conditions for protection of early Byzantine forts, and subsequently for adequate designs of reconstruction and revitalization. Key Univerzitet u Nišu Građevinsko-arhitektonski fakultet Kurtović-Folić, Nađa, 1947- Mitković, Petar Marković, Srđan. 1951- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1076 https://fedorani.ni.ac.rs/fedora/get/o:818/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533543318 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1080 2015-10-15T00:00:00Z 2

Razvoj i unapređenje metoda za proračun geotehničkih konstrukcija i primenu Evrokoda7 : doktorska disertacija DEVELOPMENT AND IMPROVEMENT OF GEOTECHNICAL DESIGN METHODS AND APPLICATION OF EUROCODE 7 Papić, Jovan Br Geotehničke konstrukcije, geotehnički proračun, parcijalni koeficijenti, proračunski postupak, teorijsko-numerička analiza In order to avoid the inequality arising from many and different civil engineering standards, rulebooks etc. present in the EU, academicians and practicioners have initiated voting a decision in 1975 for removing them and replace with set o f harmonized technical rules, known as Eurocodes. They are covering parts from Eurocode 0 to Eurocode 9, among which is Eurocode 7 which is dedicated to geotechnical design. But, its realization, due to different geographical, geological and climate conditions which leaded to development o f different local calculation traditions, was more difficult and complicated than at others Eurocodes. Anyway, in the period between 1981 and 2004 it was working intensively on exceeding the obvious differences, and which produced different format o f this Eurocode. Namely, unlike others where structure designing is pretty clear, there are three design approaches offered in Eurocode 7 and sets o f partial factors which are to be used in them. After accepting Eurocode 7, each state has to decide on two very important decisions which are related exactly on the choice o f design approach according to which designing o f geotechnical structures is going to be performed and to define appropriate partial factors. Theoretical and numerical analyses and verifications are realized in this research for such purposes for spread foundations, slopes and retaining walls, which are most often present geotechnical structures in practice. The successful results have shown that the same principle, based on keeping the similar calculation procedure and same, proved, safety level as now, can also be used for the other geotechnical structures present in Eurocode 7. Univerzitet u Nišu Građevinsko-arhitektonski fakultet Prolović, Verka, 1950- Dimitrevski Ljupčo Lukić Dragan Bonić Zoran 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1080 https://fedorani.ni.ac.rs/fedora/get/o:820/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533542806 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1081 2015-10-15T00:00:00Z 2

Utvrđivanje kriterijuma za izbor rešenja regulisanja rečnih tokova : doktorska disertacija Marković, Milica V. Hidrotehničke konstrukcije, održivi razvoj, višekriterijumska analiza People used moderate natural resources and obeyed the natural laws. Last Century of the II millennium constitutes a turning point in the relations, since it brought into question the harmony between people and the natural environment. The concept of „sustainable development“ is development which meets the needs of the present providing the ability of future generations to meet their own needs. The aim of this concept refers to the continuous improvement of quality of life and cannot be achieved if the community is not able to rationally and effectively use natural resources and ecological potential of the economy, providing an unbreakable link between economic prosperity, environmental protection and public interest. Water is an important natural resource. Engineering solutions for river training structures have a strong and long-lasting impact on the economy and society in general. Traditional structural solutions in river training works are focused on basic requirements as flood protection, littoral zone protection, river bed protection, providing the space for economic development. These solutions may lead to environmental degradation, i.e. alteration of physical-chemical and morphological characteristics of the natural components of the environment, decrease of diversity and biological productivity of natural and anthropogenic ecosystems, impacts on the ecological balance and quality of life. The main purpose of this thesis was to define a approach for the selection of hydraulic structures using multi criteria analysis, that would in addition to the basic water management requirements (flood protection, coastal protection, protection of the river bed, securing the space for economic development) provide the ecological development of rivers in accordance with the requirements of the „sustainable development“. This thesis elaborates on the application of multi criteria analysis method in selecting an appropriate alternative river training proposed solution for the section of the river course. Presented method is an aid to decision-making that helps stakeholders organize available information, think on the consequences, explore their own wishes and tolerances. Approach presented is based on the author's selection of sustainability criteria and identifies the best solution for the sustainable development of the river system, regarding to the environmental impact of proposed river training structural solution. In the case study section of the river in lower part of Carpathian Mountains is considered, for which three relevant intended alternative solutions are designed: riverbed with concrete lining, riverbed slope protection with vii gabions/gabion mattresses and natural (unregulated) riverbed. For alternative solutions respectable comparison the ELECTRE and PROMETHEE GAIA methods were applied, which allow comparison of different criteria unit measures. The main difference in the application of these methods is in defining the criteria weights, which in the method ELECTRE are exclusively subjective, while in a PROMETHEE GAIA method a respectable comparison of three scenarios of application of subjective, objective and integrated subjective and objective weights for criteria are given. For the analysis of the three scenarios defined alternatives, complete ranking of PROMETHEE GAIA method was performed using the software package Decision Lab 2000. In the case study, the final ranking of alternative solutions in both methods indicates that design of second structural solution is sustainable. MCA is not a tool providing the „right“ solution in a decision problem, since no such solution exists. The solution provided might be considered best only for the stakeholders who provided their values in the form of weighting factors, while other stakeholders’ values may indicate another alternative solution. Results obtained in the work and the conclusions derived have general character and can be applied in all areas of water management in the selection of optimal hydraulic constructive solutions. Univerzitet u Nišu Građevinsko-arhitektonski fakultet Aranđelović, Dragan Stematiu, Dan Cvetanka Popovska Đorđe Nikolić 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1081 https://fedorani.ni.ac.rs/fedora/get/o:821/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533543062 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1082 2015-10-15T00:00:00Z 2

Prilog rešenju problema stabilnosti dvopojasnih lančaničnih sistema : doktorska disertacija CONTRIBUTION TO THE SOLUTION OF THE STABILITY PROBLEM OF THE DOUBLE LAYERED CATENARY SYSTEMS Kostić, Dragan Viseće konstrukcije, Kablovske rešetke, prednaprezanje, stabilnost, dinamički uticaj vetra The paper is theoretical and practical. The double layered catenary systems are elastic suspended structures aimed at bridging great spans. Under the action of external load, these systems are prone to swinging, so the basic problem is making them stable for the potential combinations of real loads. The most efficient and most applied way of stabilization of double layered catenary systems is prestressing. The paper lays out the basic notions, history and the theoretical and practical achievements to the present times in the field of the suspended prestressed systems, and the contribution to the solving the stability problem of double layered and prestressed catenary systems. The conducted research and analysis, unequivocally demonstrate the practical results of the solution of stability problem of cable truss. The contribution to the stability problem is comprised in conclusions, which are derived from the author’s research: - Analytical-numerical model of static design - Criteria of dynamic stability of suspended structures - Analysis of defined models type “D” and “V” by the criteria of dynamic stability and the recommendations for the minimum levels of their prestressing. - Constituting the methodology of the best design of cable truss. - Definition of wind as a harmonic and impact action on the suspended structures. Key words: suspended structures, cable truss, prestressing, stability, dynamic wind action Univerzitet u Nišu Građevinsko-arhitektonski fakultet Radivojević, Grozdana 2007 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1082 https://fedorani.ni.ac.rs/fedora/get/o:822/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533482390 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1139 2015-10-16T00:00:00Z 2

Primena diverziti tehnika za rešavanje problema uticaja nečistoća u optičkim vlaknima na performanse optičkih sistema : doktorska disertacija APPLICATION OF DIVERSITY TECHNIQUES FOR SOLVING THE PROBLEMS OF THE EFFECTS IMPURITIES IN OPTICAL FIBERS ON THE PERFORMANCE OF OPTICAL SYSTEMS Popović, Zoran, 1968- Telekomunikacije We analyzed the methods for reducing the impact of noise and interference, the performance of digital optical IM-DD system. Performances of digital optical telecommunication systems, as well as their improvement, were analyzed using standard criteria for evaluation: outage probability, average probability, channel capacity, and average fading duration. These performance measures are determined on the basis of statistical characteristics of the first and second rows of signal reception and are part of the technical documentation accompanying each of the realized digital optical communication system. Therefore, the closed form of expressions, derived in this dissertation, which can be used to calculate the statistical characteristics of signal reception, represent a significant contribution, in terms of design of digital optical transmission systems. Our analysis is placed on theoretical consideration on so far untreated cases, and therefore the theoretical basis of physical phenomena that affect the transmission through the digital optical systems, well known from the literature, are not further elaborated. We included a procedure for determining the expression for the multidimensional joint probability density distribution with correlated and uncorrelated random variables. The derived expressions have a wide range of applicability and are an excellent basis for further performance analysis of optical digital transmission systems, in terms of correlated channels, as well as the characteristics of the connection by using multiple-input receiver. Their practical use is demonstrated especially in the section that deals λSK optical systems, as well as the part of that processes - the relay optical systems. Improving the transmission reliability and reducing the impact of noise and interference on the performance of digital optical telecommunication systems, with a reduction in power transmission and increasing the distance between the transmitter and receiver, is analyzed through the applying of techniques using spatial diversity reception. The dissertation discussed the various techniques of spatial combining receiving signals from the receiving branches of optical systems, in terms of reducing impact noise and interference. Ratios were formed and interference signals at the entrance combiner branches and under the terms of the previous chapter are determined by the joint probability density of these relationships for all incoming branches and the corresponding joint cumulative probability. Using this statistical feature of the incoming signal and interference are determined and statistical characteristics of signal-to-interference at the output of given combiner, which represents the next significant contribution to the dissertation. The contribution of these derived expressions can be seen from the aspect of using the results obtained for the case of the proposed statistical modeling of the channel model when considering the reduction of the impact of various types of noise and interference, and examination performance enhancements of digital optical telecommunication systems using diversity reception techniques. Specifically, by assigning appropriate values of parameters in the corresponding expressions, which describe the statistical characteristics of the first order of receipt, an analysis of the value of standard measures of performance of optical telecommunication systems, as well as improve their use of spatial diversity techniques, for cases when the communication channel is exposed to various types of interference and noises. Using the derived expressions can be shown to improve all the standard measure of performance of optical telecommunication systems. Also, when transferred unchanged forces the useful signal and interference, and at the same range of connections, get better system performance (lower values of the probability of cancellation, less the value of average bet error probability, lower average fading duration...). Based on these facts can be concluded that the required the outage probability values (ABEP) for the reception, when we apply the described techniques of receipt, in the same range of connections and the same noise power, can achieve the necessary reduction of the useful signal power in transmission, that is, at the same useful signal power, the same level of interference in the channel, the required the outage probability (ASEP) at the reception, when we apply the described techniques of receipt, can be achieved at larger distances from the transmitting terminal. Univerzitet u Nišu Elektronski fakultet Stefanović, Dimitrije 2011 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1139 https://fedorani.ni.ac.rs/fedora/get/o:826/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533475478 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1140 2015-10-16T00:00:00Z 2

Primena ortogonalnih funkcija u modeliranju dinamičkih sistema i upravljanju sistemima sa fazi kliznim režimima : doktorska disertacija Orthogonal Functions Applied in Modeling of Dynamical Systems and Control of Systems with Fuzzy Sliding Modes Milojković, Marko T., 1980- Dinamički sistemi Research aim of this dissertation is the possibility of appliance of specific, for the first time developed in such a manner, orthogonal functions in modeling and control of dynamical systems. Full historical review and modern tendencies in this area of research are given. Based on existing results, a new mathematical framework and tools are developed, useful for deriving and analyzing different types of orthogonal functions. Based on the new transformations in complex domain, orthogonal, quasi orthogonal and almost orthogonal functions are derived, suitable for application in technical systems. Functions obtained in such a manner are used for designing orthogonal, almost and quasi orthogonal filters which can be successfully used in electronics, circuit theory, digital signal processing, telecommunications... This dissertation emphasizes their potential use in modeling and control of dynamical systems. All designed filters are also practically realized as printed circuit boards and verified by experiments. Optimal approximation of the real signals in the form of orthogonal developments enables modeling of dynamical systems using new orthogonal functions with great simplicity and accuracy. This is demonstrated by experiments and comparative analysis with other modeling methods on three-tank hydraulical system, DC servo drive and transport system. Developed functions are also very convenient for the design of optimal and adaptive control systems. This is demonstrated with experiments on practically realized antenna system. Functions are also used in order to improve performances of systems with fuzzy sliding modes control. Series of experiments on anti-lock braking system are performed to demonstrate the advantages of such a control over other types of control. Univerzitet u Nišu Elektronski fakultet Antić, Dragan 2011 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1140 https://fedorani.ni.ac.rs/fedora/get/o:827/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533471894 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1188 2015-10-16T00:00:00Z 2

Efekti treninga adaptivne košarke na specifično motoričke i funkcionalne sposobnosti adolescenata sa mentalnom retardacijom : doktorska disertacija THE EFFECTS OF AN ADAPTED BASKETBALL TRAINING ON THE SPECIFIC MOTORIC AND FUNCTIONAL ABILITIES OF ADOLESCENTS WITH MENTAL RETARDATION Stanišić, Zoran 1958- Adaptivna košarka, motoričke sposobnosti, mentalna retardacija adapted basketball training, specific motoric abilities, functional abilities, adolescents with mental retardation, effects. The research was conducted in order to determine the effects of an adaptive training basketball on the transformation of specific motoric and functional abilities of adolescents with mental retardation. The sample consisted of 60 adolescents with mental retardation, pupils of School for elementary and secondary education "14 October" in Nis, Serbia, aged 13 to 17 years, of both sexes. The experimental group was composed of 30 adolescents with mental retardation, 12 girls and 18 boys selected for training adaptive basketball in physical education classes, four times a week for 30 minutes for a period of eight weeks. The control group was also made up of 30 adolescents with mental retardation, 10 girls and 20 boys who attended the classes of regular physical education program, four times a week for 30 minutes for a period of eight weeks. In the research was used measurement instruments to assess the anthropometric characteristics (three), specific motoric (four) and functional (four) abilities. Basketball test battery included a four ability levels of increasing difficulty, from the first to the fourth, each one characterized by the analysis of the four main areas related to the technical and fundamental aspects of the game: ball handling, reception, passing and shooting. Each area is divided into five specific components, in which the participants receive individual score: 1 point for correct efficiency, 0.5 points for misinterpretation and 0 points for a complete failure. For each level, the examinee can reach a maximum of 20 points. Moving to the next level is determined by winning at least 15 points. In addition to the basic statistical parameters, the results were analyzed by analysis of variance and covariance and canonical discriminant analysis. Results of the research indicate that the experimental group participants achieve better results in the studied area, and that there were significant effects of adaptive training of basketball in the final test. Univerzitet u Nišu Fakultet sporta i fizičkog vaspitanja Kocić, Miodrag Berić, Dragana Aleksandrović, Marko Simović, Slobodan 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1188 https://fedorani.ni.ac.rs/fedora/get/o:830/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533516694 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1193 2015-10-16T00:00:00Z 2

Biomarkeri apoptoze i ćelijske signalizacije u patogenezi kolorektalnog karcinoma : doktorska disertacija BIOMARKERS OF APOPTOSIS AND CELL SIGNALING IN COLON CANCER PATHOGENESIS Veljković, Andrej R. 1980- Kolorektalni karcinom Colorectal cancer, oxidative stress, apoptosis, proliferation Colorectal cancer is one of the most frequent neoplastic diseases in human population and one of the most frequent causes of death. There are a lot of pathological factors, involved in the process of colon cancer initiation, propagation and progression, among other ROS, who can activate Nuclear transcriptional factor kappa B (NF-B), who controls genes involved in tumor progression.Apoptosis is a process involved in the development of tumors, where blocking apoptosis avoids removal of malignant cells.The matrix metalloproteinase’s generally function to degrade proteoglycans and matrix glycoprotein’s and facilitate the development and metastasis of tumors. Enzymes of purine nucleotide metabolism may be very important in tumor proliferation. The aim of the present study wasthat in 50 patients with colorectal cancer to assess the levels of oxidative stress , quantitative expression of NF-B, level of apoptosis expressed in endonuclease activity and Bcl2 / Bax ratio, the activity of matrix metalloproteinase 9, and the activity of the enzyme of purine nucleotides in homogenates of tumor tissue, the tissue immediately surrounding the tumor and healthy colon tissue. The concentrations of TBARS and AOPP, and enzyme activities were determined by appropriate spectrophotometric methods, quantitative expression of NF-B, Bcl2 and Bax, and the activity of MMP-9 were determined by appropriate immunofluorescence methods. The concentrations of TBARS, AOPP, MMP-9 activity, xanthine oxidase, adenosine dezaminaze and quantitative expression of NF-B and Bcl2 in the tumor tissue increased compared to healthy colon tissue. Catalase activity and quantitative expression of Bax was decreased in tumor tissue compared to healthy colon tissue. The tissue surrounding the tumor also had significantly higher TBARS, AOPP, NF-B, Bcl2, and increased activity of MMP-9, ADA, XO compared to healthy tissue. Our results show that the tumor has an increased level of oxidative stress, increased levels of markers of proliferation, but decreased levels of apoptosis compared to healthy colon tissue. The surrounding tissue is also proliferativeactive with reduced levels of apoptosis. These facts may be relevant in determining the operating margin removal of the tumor, followed by the creation of individual therapeutic strategies in inoperable condition or in patients with bone metastases. Correlation with histological findings, tumor stage and other clinical characteristics of each patient would enable a more accurate assessment of invasiveness and aggressiveness of the tumor and the selection of appropriate therapy. Univerzitet u Nišu Medicinski fakultet Kocić, Gordana Kostić, Danijela, 1969- Stanojević, Goran Pavlović, Dušica Jevtović-Stoimenov, Tatjana 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1193 https://fedorani.ni.ac.rs/fedora/get/o:832/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024530669 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1194 2015-10-16T00:00:00Z 2

Morfometrijske i imunohistohemijske karakteristike parahipokampalne kore velikog mozga čoveka tokom procesa starenja : doktorska disertacija Bakić, Mirjana, 1976- Veliki mozak Aging of the parahippocampal cortex is accompanied by reduction of its volume or thickness, which is commonly associated with loss and changes of nerve cells. The most common changes include cell number reduction, deposition of lipofuscin, formation of corpora amylacea in astrocytes, and reduction of cortex vascularization, which may represent the basis for the development of cognitive dysfunction. Endothelium of blood vessels is the place where first changes occur, which eventually results in disruption of haematoencephalic barrier and amyloid deposition originating from the circulation both within their walls, and in the brain parenchyma. These changes may represent not only an integrative part of normal aging, but occur within neurodegenerative disorders, as well, Alzheimer's dementia, in particular. The aim of this research was to carry out quantification of structural changes in different cortical layers (subpial, subcortical, lamina II-V) on human parahippocampal cortex tissue obtained from autopsies without previous diagnosis of diseases of the nervous system, using histochemical, immunohistochemical and morphometric methods, as well as determine neurone deficit, proliferation of glial cells and the existence of structures known as corpora amylacea using immunohistochemical methods (NSE, GFAP, S100). The research has shown that during normal aging, in parahippocampal cortex there occurs increase in the number of corpora amylacea localized in subpial region that is even higher in subcortical white matter, with no significant change in the size and shape. Positive reaction to NSE, determined by immunohistochemical methods, probably indicates the presence of neural components, while a weaker reaction to GFAP and positive reaction to S100 protein indicates that corpora amylacea are likely to be astrocyte inclusions. The number of nerve cells with deposits of lipofuscin of the examined samples increases significantly with age. The results in the obtained age groups indicate that number of neurons and astrocytes in parahippocamplal cortex is balanced and their relationship does not significantly change during the aging process. Interrelationship between the obtained results suggests that the presence of above mentioned structural changes may lead to damage of those brain structures that are responsible for normal memory function and thus responsible for the cognitive changes present in healthy elderly persons. Univerzitet u Nišu Medicinski fakultet Jovanović, Ivan Ugrenović, Slađana Stefanović, Natalija 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1194 https://fedorani.ni.ac.rs/fedora/get/o:833/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024540909 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1195 2015-10-16T00:00:00Z 2

Eksperimenti sa difrakcijom svetlostii njihov značaj za nastavu fizike : doktorska disertacija EXPERIMENTS WITH DIFFRACTION OF LIGHT AND THEIR SIGNIFICANCE FOR TEACHING PHYSICS Nikolić, Dragiša M. Optika Diffraction The new set of laboratory practices for school, concerning difraction of light were presented in this work. Effects of their practical realisation on students skill level, habits and understanding level were certified in pedeagogic experiment, which has confirmed our theoretical assuimptions. Univerzitet u Nišu Prirodno-matematički fakultet Nešić, Ljubiša, 1966- Stojanović, Maja Gocić, Saša, 1972- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1195 https://fedorani.ni.ac.rs/fedora/get/o:835/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024536041 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1255 2015-10-16T00:00:00Z 2

Imunohistohemijska i morfometrijska analiza psamomatoznih telašaca horoidnog spleta u toku starenja čoveka : doktorska disertacija Jovanović, Ivan D. Horoidni pleksus, humani Univerzitet u Nišu Medicinski fakultet Antić, Svetlana Stefanović, Natalija Anđelković, Zlatibor 2006 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1255 https://fedorani.ni.ac.rs/fedora/get/o:843/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/532954262 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1261 2015-10-16T00:00:00Z 2

Primena multimarker pristupa u proceni rizika kod pacijenata na dijalizi : doktorska disertacija APPLICATION OF MULTIMARKER APPROACH TO RISK STRATIFICATION AMONG PATIENTS ON DIALYSIS Ignjatović, Aleksandra 1980- Bubrežne bolesti Introduction:The mortality rate of hemodialysis patients is very high, 10-20 times higer than in general population. Cardiovascular disease is reported to be major cause of death. By using this approach many different pathophysiological components will be covered. For validation one marker or combination of few markers as risk factors is needed to perform several statistical tests. Aim:The main goal of this thesis is to compare predictive values of ADMA as marker of endothelial dysfunction, CRP and SAA, as markers of inflammation and albumin as marker of malnutrition among patients on dyalisis,and in addition to create a common predictive value for patients with several risk factors. Methods:In this 3-years follow-up stady, plasma concentrations of ADMA and SDMA was measured by HPLC. CRP was measured using immunoturbidimetricassays; SAA was measured using immunonephalometric assays. Albumin level was obtained using standard clinical laboratory methods. Importance: The use of multimarker approach in evaluating markers of endothelial dysfunction, inflammation and malnutrion gives a new data related to risk stratification among patients on dialysis. This research shows that all markers are independent proctors of all-cause and cardiovascular cause of death. It is demonstrated that combined use of biomarkers increases the predictive power of prognostic model, whichwould improve risk stratification among patients on dyalisis.Best combination of markers for risk stratification is ADMA and albumin. Study of assessment of novel markers as risk factors contributes to better classification patients on dialysis in groups with different risk level. Therefore, management and treatment of patients on dialysis is adjusted by risk level. Univerzitet u Nišu Medicinski fakultet Cvetković, Tatjana 1965- Pavlović, Dušica Milošević, Zoran Veličković-Radovanović, Radmila 1961- Bogdanović, Dragan 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1261 https://fedorani.ni.ac.rs/fedora/get/o:846/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024665069 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1273 2015-10-16T00:00:00Z 2

Regulacija metabolizma gvožđa, nivo hepcidina i transferinskih receptora kod pacijenata na hemodijalizi : doktorska disertacija THE REGULATION OF IRON METABOLISM, THE LEVEL OF HEPCIDIN AND TRANSFERRIN RECEPTORS IN HEMODIALYSIS PATIENTS Jelić, Marija 1974- Bolesti bubrega, Klinička biohemija Introduction:The most common anemia caused in patients with chronic kidney insufficiency is reduced erythropoetin (EPO) synthesis due to the impacted kidneys. Iron supplementation is essential in order to provide adequate EPO therapy response in patients with CKD because bone marrow’s demands for iron often exceed the amount of needed iron required for erythropoesis (transferrin saturation percentage) or iron stores (serum ferritin). Apart form iron, sufficient amount of other main supstrates and cofactors must be supplemented for erythrocyte synthesys, especially vitamin B12 and folates. Markers for monitoring anemia status, as well as iron and erythropoetin therapy effects identification is of vital importance. Aim: The aim of this research is to identify not only the standard biochemical markers, but also the new markers for iron metabolism status regulation, currently not widely used, hepcidin and soluble transferrin receptor concentration; correlation of signifficant anemia the parameters and iron metabolism parameters in targeted groups of patients; to determine the predictive value of iron concentration, hepcidin, sTfR and ferritin concentration values in patients on hemodialysis; to determine mean ferritin, hepcidin and sTfR value sensitivity and specificity in patients with saturation values over/below 30%; to estimate the signifficance of hepcidin and sTfR in iron metabolism regulation in patients on hemodialysis. Patients and methods: This research covered 124 patients, 104 with chronic kidney disease - 64 on hemodialysis and 40 in predialysis stage. Control group included 20 healthy volunteers. In addition to the standard biochemical markers, anemia parameters, folic acid and vitamin B12,iron metabolism parameters, iron,TIBC, UIBC, transferrin saturation, ferritin, hepcidin and soluble transferrin receptor concentration were determined. Importance: Up till now the applied biomarkers had certain limitations which didn’t allow making an early anemia diagnosis and a more adequate therapy contorl in patients with chronic kidney insufficiency. An extremely huge deployment of different iron products, erythropoietins and vital periodic transfusions demands for finding an early, efficient and reliable biomarker for good rationalization and even better individualisation of the applies products. The results of the research show that hepcidin and soluble transferrin receptor concentration values as part of regular dialysis patient control greatly improves the understanding of iron metabolism and distribution in these patients. It has been proved that hepcidin concentration is influenced by inflammation, hypoxia and hypoalbuminemia, allowing soluble transferrin receptor concentration levels to be a reliable iron deficiency marker in patients on hemodialysis. Univerzitet u Nišu Medicinski fakultet Cvetković, Tatjana 1965- Đorđević, Vidojko Kocić, Gordana Stojanović, Ivana 1962- Grubor-Lajšić, Gordana 1949- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1273 https://fedorani.ni.ac.rs/fedora/get/o:848/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024680429 sr Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)

oai:eteze.ni.ac.rs:1274 2015-10-16T00:00:00Z 2

Značaj nivoa vitamina D i polimorfizama gena povezanih sa njegovim delovanjem kod obolelih od multiple skleroze : doktorska disertacija THE IMPORTANCE OF VITAMIN D LEVELS AND GENE POLYMORPHISMS RELATED WITH ITS ACTING IN PATIENTS WITH MULTIPLE SCLEROSIS Savić, Dejan 1973- Multipla skleroza Multiple sclerosis is disease which affect 2,5 million people worldwide and is one of the most frequent nontraumatic disabling neurological disorder among young adults. Multiple sclerosis is complex disease and so demands interaction between genetic and envinronmental factors. Among the environmental factors vitamin D has specific importance. The aims of this study were estimating the vitamin D levels in multiple sclerosis patients and comparing with healthy individuals to estimate their importance in disease originate. We determinate single nucleotide polymorphisms rs2282679 for the vitamin D binding protein gene and rs10741657 for mycrosomal enzyme CYP2R1 gene and single nucleotide polymorphysm FokI (rs2228570) for vitamin D receptor gene. Our results showed vitamin D insuffitiention in both groups with significantly lower values in multiple sclerosis group. Polymorphism rs2282679 for the vitamin D binding protein gene gene showed significant connection with vitamin D levels in healthy pepole. Vitamin D levels correlated with the degree of disability in patients group and disease type (secondary progressive versus relapsing - remitting). No one polymorphysm showed increasing the risk fom multiple sclerosis. Vitamin D insuffitiention in whole population could be the aim for preventive acting, by suplementation of this essential dietetic product, esspecially according to its connection with the degree of neurological dysability. Established association between sertain polymorphisms and vitamin D levels could be means in establishing the aiming group for prevetive treatment. These study results represents one more piece in understanding this complex and underestimated disease. Univerzitet u Nišu Medicinski fakultet Vojinović, Slobodan Zoran Perić Slobodan Vojinović Evica Dinčić 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1274 https://fedorani.ni.ac.rs/fedora/get/o:849/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024680173 sr Autorstvo-Bez prerade 3.0 Srbija (CC BY-ND 3.0)

oai:eteze.ni.ac.rs:1275 2015-10-16T00:00:00Z 2

Glikogen fosforilaza tip bb i hit šok protein 27 - indikatori miokardnog stresa kod vaterpolista : doktorska disertacija Glycogen phosphorylase type bb and heat shock protein 27- indicators of myocardial stress in water polo players Slavić, Vjeroslava G. 1972- Miokard, glikogen fosforilaza, hit šok protein 27, napor, miokardni stres, vaterpolo Glycogen phosphorylase, heat shock protein 27, effort, myocardial stress, water polo Introduction: In recent years, there is an evidence of many sudden cardiac deaths among elite athletes. The risk of myocardial damage in long-term exercise has been much debated because it has been reported that exercise increased serum concentration of cardiac biomarkers in elite athletes but also in people who were involved in recreational sports. Although numerous studies have been performed, it is still unclear whether the increase in these markers in healthy athletes is clinically significant or is a part of the physiological response to prolonged exercise. Glycogen phosphorylase type bb (GP-BB) is segregated as an enzyme with high specificity to myocardial cells and high sensitivity for clinical diagnosis of early myocardial ischemia. GP-BB is a glycolytic enzyme responsible for the mobilization of intracellular glucose from glycogen depots under conditions of ischemia to compensate “hunger” tissue for energy. In the process of glycogenolysis, GP-BB is converted to soluble, monomeric cytoplasmatic structure with consequent creation of a concentration gradient that is necessary for the release of protein in the blood. Since it is a metabolically active enzyme, its release from cardiac cells does not require a cell death and/or necrosis. Heat shock proteins (Hsp) are evolutionarily conserved protein structures with an important role in monitoring and/or supervising of the process of synthesis of structural and functional cellular proteins. They are present in all human cells and make 5 to 10% of total intracellular protein content. After cell exposure to stressor, their content increases to 15%. Hsp27 is responsible for cytoprotective processes which inhibit apoptosis. The expression and synthesis of Hsp27 transiently increase in response to stressor and upon the cessation of stress its concentration rapidly returns to baseline value, which makes it a very sensitive indicator of acute events at the cellular level. In recent years, numerous in vitro and in vivo studies have confirmed a strong protective effect of Hsp27 on ischemic myocardial cell damage. The aim of this study was to determine an importance of GP-BB and Hsp27 as sensitive and specific markers for the assessment of early myocardial stress in water polo players. Materials and Methods: A prospective and experimental study included 20 male water polo players, randomly divided into two groups that matched for gender, age, length of active practicing water polo and level of physical stamina: (1) group exposed to a strenuous exercise training (experimental group, n = 10), (2) group that was not trained (control group, n = 10). Blood samples for testing were obtained at the following time points: baseline, 1, 30 and 60 minutes following the exercise. The control blood samples were obtained at equivalent timepoints. The concentrations of GP-BB and Hsp27 were determined by immunosorbent tests associated with enzymes (sandwich ELISA) using commercial quantitative kits (Diagenics, USA for GP-BB, Calbiochem, USA for Hsp27). The color intensity was read at 450 nm on the spectrophotometer (Microplate Manager Bio-Rad Laboratories, Inc.). The results were statistically analyzed using the statistical package for Windows, version 17.0 (Statistical Package for Social Science-SPSS Inc., IL, USA). Statistically significant differences were considered as the values of p <0.05 and p <0.001. Results: Serum concentrations of GP-BB before training/basal were within the normal range in all water polo players. After training, higher concentrations of GP-BB occurred in 40% of subjects after the first and thirtieth and 10% after the sixtieth minute. In the control group, the concentrations of this enzyme were unchanged, but there were a certain dynamic in the time intervals and significant difference in serum concentrations between the groups of water polo players only at the last time point (p <0.025). Serum levels of Hsp27 were elevated in all water polo players before training/baseline. However, after training increased concentrations of Hsp27 were observed in 50% water polo players after the first, 60% after the thirtieth and 80% after the sixtieth minute. In the control group of water polo players, higher concentrations were detected in 30% of the subjects after the first, 70% after the thirtieth and 20% after the sixtieth minute. At the observed time intervals, there were no significant differences in the concentrations of Hsp27 between the groups. Serum concentrations of GP-BB and Hsp27 were significantly positively correlated after the first (p <0.05) and thirtieth minutes (p <0.01). Conclusion: The increase in serum concentrations of GP-BB in water polo players by strenuous training point to the existence of metabolic exhaustion of myocardial cells which is reversible. It is accompanied by an increased proteolytic activity in these cells through a decrease in serum concentrations of Hsp27 after exertion. Damage of the protein structure in the myocardial cells, structural and functional, is reversible because the serum concentrations of GP-BB and Hsp27 were significantly correlated in the first and thirtieth minutes after effort. Our results suggest that the GP-BB and Hsp27 could be important indicators of the risk assessment and prevention of developing heart damage in water polo players, but with athletes at all. Univerzitet u Nišu Medicinski fakultet Kamenov, Borislav Ilić, Stevan Radovanović, Dragan Nikolić, Goran 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1275 https://fedorani.ni.ac.rs/fedora/get/o:850/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024692973 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1276 2015-10-16T00:00:00Z 2

Analiza i ocena održivog razvoja energetskog sistema u zgradarstvu : doktorska disertacija Analysis and evaluation of sustainable development of the energy systems in buildings Vučićević, Biljana S. 1969- Potrošnja energije, Grejanje, indeks održivosti, nelinearna normalizacija, fazi logika Sustainability index Cities are very high populated urban areas and consequently very large consumers of final energy. Their main characteristic is the largest share in energy consumed by residential building sector. Therefore, paying attention to the energy use assessment in residential building sector, at the same time with assessing quality of living, is especially important. Indicators of sustainable development represent essential characteristics for evaluating energy consumption and living quality in residential buildings. In this paper qualitative characterization of the considered objects is performed based on the period of construction (1946-1980 and 1981-2006), type of heating system (electricity, district heating and fossil fuels) and type of object (single family houses and apartments) for the city of Belgrade. Representative sample was taken into account and, based on the qualitative characterization, divided in nine subgroups (options). Eleven economic, social and environmental subindicators were selected and calculated for all chosen options to present energy consumption necessary to meet the needs of occupants for space heating, hot water production, cooking, household electrical appliances, indoor air quality, living space, etc. Multicriteria analysis, having application in decision making policies, was used to evaluate sustainability of different residential options through sustainability index calculation. This mathematical procedure was conducted by agglomeration of normalized subindicators´ values into economic, environmental and social indicators (first level) and agglomeration of indicators into sustainability index (second level). In order to investigate the effect of nonlinearity on the sub-indicators' agglomeration, the change in nonlinearity was introduced in the procedure. Normalized sub-indicators are obtained by selection of the appropriate linear (θ1= θ2=... =θ11=1) or non-linear parameters (θ1, θ2,..., θ11; θj≠1). Sustainability index and it´s standard deviation were calculated for different values of the parameter θ and each option. The functional dependence between the sustainability index and the associated standard deviation of the θ parameter (characterizing the way of normalization) was obtained. Univerzitet u Nišu Mašinski fakultet Stojiljković, Mladen 1951- Blagojević, Bratislav Todorović, Maja 1971- Stefanović, Gordana Jovanović, Marina 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1276 https://fedorani.ni.ac.rs/fedora/get/o:851/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533590678 sr Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)

oai:eteze.ni.ac.rs:1285 2015-10-16T00:00:00Z 2

Merenje koncentracije i tržišne moći privrednih subjekata u funkciji unapređenja politike zaštite konkurencije : doktorska disertacija MEASURING CONCENTRATION AND MARKET POWER OF ECONOMIC ENTITIES IN FUNCTION OF IMPROVING COMPETITION POLICY Radivojević, Vladimir M. Zaštita konkurencije, ekonomska efikasnost,društveno blagostanje, konkurencija, tržišna koncentracija economic efficiency, social welfare, competition, market concentration, market power, competition policy, Serbian sugar market In economic theory, it is generally accepted thesis that greater competition increases economic efficiency and hence overall social welfare. Therefore, the establishment of competitive market structure is one of the primary intentions of every market-oriented economy. The practice of developed countries clearly confirmed that law and competition policy are an essential part of the institutional framework within which effective market economy operates. All of the key phenomena dealt by competition policy are explained on the basis of modern economics findings. Economic explanation of these occurrences allows cognition of causes, mechanisms and consequences of the phenomenon of competition and its distortion. The aim of this thesis is to highlight the importance of competition policy and to contribute to the identification and analysis of non-competitive market structures, i.e. anti-competitive behavior of market participants. The proposed theoretical-methodological and econometric instrumentation allows analysis of market structure, analysis of market participants behavior and the analysis of effects of that behavior on economic efficiency and social welfare. Results obtained by these analytical apparatus provides a good basis for objective, unbiased, and (to some extent) standardized reasoning and identification of anti-competitive behavior. An empirical examination of the proposed instruments in done on the example of the Serbian sugar market. The results indicate significant problems facing Serbia in the process of building an efficient market economy based on competition. Univerzitet u Nišu Ekonomski fakultet Stojanović, Boban 1958- Stanković, Ljiljana Maksimović, Ljiljana 1956- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1285 https://fedorani.ni.ac.rs/fedora/get/o:854/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533590422 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1286 2015-10-16T00:00:00Z 2

Sistem kontrolisanja državne pomoći u funkciji zaštite konkurencije u procesu integracije Srbije u Evropsku Uniju : doktorska disertacija SYSTEM OF CONTROLLING STATE AID IN FUNCTION OF PROTECTION COMPETITION IN THE PROCESS OF SERBIAN INTEGRATION IN THE EUROPEAN UNION Stanišić, Tanja S. 1983- Konkurencija, Zaštita konkurencije, državna pomoć, kontrola, Европска унија state aid, competition, control, Serbia, European Union. Abstract: Synchronized efforts in the field of monitoring and control activities of the company in the market, as well as activities of the state, are precondition of the existence of effective competition policy. State aid as a form of selective government interventions aimed to individual companies, sectors and regions, can distorts competition in the market. Hence, the establishment and consistent implementation of the system of controlling state aid as an important part of the competition policy are necessary. The theoretical - methodological base of the system of controlling state aid is exposed in this research. The concept of state aid is determined precisely and the steps in the process of system building are systematized. The study further highlights compatibility between state aid control and protection of competition. A wide range of effects of state aid on competition process requires consideration of potential changes in costs, revenue, market behavior and market share of state aid beneficiaries. Valid conclusions about the impact of state aid on competition and social welfare are formulated in the research by extending standard microeconomic model with assumption of state aid. The EU system of state aid control is identified and analyzed as the most efficient existing system. Understanding its legal basis is a good starting point in designing of national system of state aid control. Identifying the trend in the European Commission work, as the body responsible for the state aid control in the EU, allows the formulation of guidelines for future action of national monitoring authorities. Review of achieved results in the system of state aid control in Serbia, as a new theoretical and practical concept, is carried out through comparison with the EU system and the systems of the countries in the region. In this way, we systematized the existing deficiencies and formulated recommendations for further development that would lead to increased transparency and efficiency of the Serbian system. Comparative examination of trends in granted state aid pointed to negative deviations in Serbia in relation to good practice of European Union. We identified areas to which Serbia should direct state aid in the future. The objective of doctoral dissertation is pointing out the great importance of the system of controlling state aid as the field of competition policy and the need for a serious approach to the process of its construction. The purpose of the research is identifying existing weaknesses and possible directions of further development of system in Serbia. In accordance with the objective and the purpose of the research, various methods are applied in iv this study. The method of comparative legal analysis is widely used in comparison obtained solutions in Serbia with the country in the region and with the best international practice. Microeconomic models, with their extension by assumption of existence of state aid, were used to isolate channels of impact of state aid on competition. Statistical methods (descriptive statistics, cluster analysis, correlation analysis) allowed the identification of the causal relations between researched variables. The graphical representation is used to make conclusion about relevant regularities of manifestation of the state aid on the basis of existing data. The research presents more complete analytical coverage of issues of state aid control, which is new in domestic scientific and professional community. Research results created the basis for learning from positive and negative experiences of countries that regulated this very important issue (for both, protecting competition and the efficient use of public funds) much earlier than Serbia. Univerzitet u Nišu Ekonomski fakultet Stojanović, Boban 1958- Milenković-Kerković, Tamara Maksimović, Ljiljana 1956- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1286 https://fedorani.ni.ac.rs/fedora/get/o:855/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533590166 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1287 2015-10-16T00:00:00Z 2

Jezik, rod, razlika: konstrukcija/dekonstrukcija identiteta u (post)feminističkoj teoriji : doktorska disertacija LANGUAGE, GENDER, DIFFERENCE: THE CONSTRUCTION/DECONSTRUCTION OF IDENTITY IN (POST)FEMINIST THEORY Mitić, Petra 1966- Anglistika,feministička teorija, rodni identitet, razlika, simbolički poredak, psihoanaliza, poststrukturalizam, postmodernizam, esencijalizam/konstrukcionizam, humanizam feminist theory, gender identity, difference, symbolic order, psychoanalysis, poststructuralism, postmodernism, essentialism/constructionism, humanism This dissertation starts with the conviction that contemporary feminist theory should not be considered as just one among the current critical theories, but rather as a critical domain where truly significant deconstructions of patriarchal ideology and power have been produced. This theory has also been labeled postfeminist – the reason being that feminist thought can no longer be looked upon as a separate discipline, but a theoretical and political space where theories and practices from other disciplines, and with different agendas, come together and intersect. Also, the prefix ‘post’ is the result of a crisis which began at the moment when the theoretical impulse of psychoanalysis, and then poststructuralism, started to affect the feminist discourse, which, in its turn, has provoked numerous debates, disagreements and even open dissent within the movement. In order to see if feminism can still be used to initiate and promote a truly critical consciousness – now that the political activism of the first two waves is behind us – we need to determine its position among the current strands of cultural theory, as well as to understand the complex relationship between all these critical theories which have shaped the feminism of today. The task we set was to explore these relations and understand the ways in which these theories have overlapped with feminism, so that it could be possible to define the role of feminism today in a more meaningful and productive way. The conflictual positions within feminism do not let us speak about a coherent theory or the common stand, but rather about multiple theories and opposing positions, which has definitely contributed to both the challenge and the complexity of the task. The history of the feminist thought is a testimony that identity has been the issue of crucial importance from the very beginning, as well as the focus of any serious attempt to critically examine the relationship between culture and the individual, and the particular position that women have been assigned in culture and society. While tracing the development of the feminist understanding of identity, the centre of our critical attention has been the crisis brought about by the so-called linguistic turn which happened around the middle of the twentieth century. It was at this time that, under the influence of Lacanian psychoanalysis and poststructuralism, feminist theorists started to debate the idea of constructionism – as opposed to essentialism. But the crisis brought about by deconstruction, feminism, and postmodernism working together has also proved to be productive for feminist theory. While it is true that this crisis has destabilized the very foundation of the feminist movement – woman being the subject on whose behalf it is supposed to act – it has also helped us understand and define the underlying assumptions of this significant disagreement. The concepts of language, gender and difference occupy the central spot in a theory which has been polarized in this manner, and it was through examining these particular concepts that we were able to understand the meaning and the consequences of the many attempts to either construct or deconstruct the woman and the feminine. A truly feminist stance has actually always required that we put our efforts into constructing an identity which could be politically justified, while striving at the same time to deconstruct a fixed category of the feminine. Since the mainstream of feminist history has been marked by the tendency to use polarized and mutually exclusive modalities of equality and difference, we were able to conclude that this particular choice has not only led us astray, but has also prevented feminist theory from articulating a more appropriate framework which could be used to examine the historical forms of intersection between gender and all the other structures of oppression. Our analysis of opposing perspectives with regard to the issue of identity, and within the framework we have thus articulated, has proved useful in our attempt to shed more light upon the conflicts in the past, and even more so in our attempt to conceive a more meaningful future. It is our conclusion that this future should not take the antihumanist (or posthumanist) turn which some postmodern feminists have advocated, but rather the position that we must not be afraid to call – radical humanism. It is the kind of humanism which should not try to cancel or deny the implications of a discursively constructed subjectivity, but which should also insist upon the individual and collective responsibility for prioritizing a particular set of meanings that – in specific historical and cultural circumstances – become a shaping force for personal and group identities. Deconstructing gender stereotypes which have been used to support patriarchy can still remain a key reference for feminist politics, but the relevance of its connection to the entire social and political framework of power structures needs to be established and made clear. Emphasizing difference as the basic category of identity should not be an obstacle but a meaningful platform for building feminist consciousness – by criticising all forms of cultural, economic, or political inequality as well as promoting solidarity as the most precious legacy of both humanist tradition and feminist thought. Univerzitet u Nišu Filozofski fakultet Petrović, Lena 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1287 https://fedorani.ni.ac.rs/fedora/get/o:856/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533589654 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1289 2015-10-16T00:00:00Z 2

Razvoj i promene u afektivnoj vezanosti u adolescenciji : doktorska disertacija Development and change of attachment in adolescence Vukčević, Branimir N. 1978- Adolescenti, transfer afektivne vezanosti, hijerarhija afektivne vezanosti, podudarnost stila afektivne vezanosti transfer of attachment, attachment hierarchy, attachment style, adolescence Plenty of scientific papers on attachment that was created during the twentieth and beginning of this century show that the attachment system is an important factor in the development of children and adolescents. The aim of this study was to investigate the development and change of attachment of adolescents. The sample of empirical study included 310 adolescents aged 14 to 19, i.e. eighth grade elementary school students, second and fourth grade high school students. Areas of inquiry in this study were: 1) hierarchy of attachment in both sexes, 2) transfer of attachment 3) the congruence patterns of attachment and the importance of secure parental and peer attachment to adolescent adjustment, 4) the association between strength (power) and dimensions of attachment, and 5) the problem of differentiation/generalization of attachment during adolescence. In order to explore dimensions of distance (internal working model of other) and anxiety (internal working model of self) we used a DAR questionnaire (short form of ECR-R, Fraley et al.; translated in Serbian and constructed by Vukcevic). For the classification of adolescents in attachment patterns of attachment we used the data obtained by Rash analysis scale of DAR questionnaire. To test the strength and hierarchy of attachment, we used the version of WhoTo questionnaire in Serbian language (Hazan and Zeifman; translated and adapted by Vukcevic). We used a Self Concept questionnaire by the author Opacic; we also used a ROK questionnaire (Abbreviation in Serbian of the Relational self competence questionnaire, constructed by Vukcevic), which among other things, examines the self worth in relations with father, mother and best friend. To test communication, trust and alienation in relationships with parents and peers, we used the version of IPPA-R in the Serbian language (Arsmden and Greenberg; translated and revised by Vukcevic). Socio-demographic variables, variables that indicate the degree of consumption of alcoholic beverages, cigarettes, duration of the relationship with best friend, school achievement (the average of school marks at the end of previous school year) and the present number of unexcused absences from school, were examined separate questionnaire that was designed for this study. IX 1) The findings suggest that the hierarchy of attachment develops differently during adolescence depending on the sex of the respondents. At girls, the hierarchy of attachment has a stable structure in which the mother is on the first, a friend on the second, a sibling on the third rank, as a father figure slowly falling in the hierarchy during adolescence. At boys, both parents are all the time in the top of the attachment hierarchy, and therefore father figure is more important for boys than girls. The role and support of father in development of mail adolescents should be more investigated. Also, at boys, family and peer figures in the attachment hierarchy become consistent to the fourth grade; this happened most likely due to differences in the development of gender identity. Boys strive toward autonomy more than girls, so boys must develop and use attachment system in close relationships out family context more than girls. 2) In this paper the transfer of attachment is defined as a process of internal working models of attachment to parents on internal working models of attachment for a friend, which in turn impact on the strenght of attachment for a friend. This process here is conceptualized as the influence of adolescents` attachment to mother on attachment to best friend (peer figure), and as the influence of adolescents` attachment to father on attachment to best friend. As a moderator of this action, we examined the strengths of attachment to mother and father, self-esteems in relation with mother and with father, and variable named transfers` index and which expressed the level of difference between the strenght of attachment for a friend and the average of attachment strenghts to mother and father. For examining transfer, we used the Hayes` SPSS macro that monitors models of mediation moderation. The findings show that the internal models of attachment to parents have effects on peer attachment through the same kind of internal models of attachment to peer. Strength of attachment to a father is a moderator transfer of attachment to parents towards friends. The strength of attachment to a father, the greater the transfer of attachment to father on peer attachment. Self-esteem in the relationship with a mother is a moderator transfer of attachment to the mother on peer attachment. The greater self-esteem in the relationship with a mother, the greater the transfer. The findings show that the index transfer is a moderator transfer of attachment from parents to peers, but the greater the change of the hierarchy attachment, the lower degree of transfer of attachment. Change of attachment hierarchy, which means that the peer figures X become more important than parents during adolescence serves to compensate for shaky quality of bond with parents and is not based on the transfer of attachment. Compensatory changes of attachment was based on the development of trust and communication with a close friend, while at the same time there is little trust, poor communication and alienation expressed in relation with the parental figures. 3) There was a confirmed accordance pattern of attachment to parents and close friends. Respondents who had a match secure attachment to parents and close friends were developing a more morality as an aspect of self concept and positive self worth in the relationship with a mother, father and close friends; also they smoke and drink alcohol less than other adolescents. However, the findings suggest that secure attachment to friends compensate for the negative effects of insecure attachment to parents on self concept. Secure attachment to parents or to peers as a support system provides better general aspects of adolescents' self-concept and acceptance of desirable behavior in a social context where these persons are located (which in turn may not always be favorable circumstances for the healthy development). 4) The findings suggest that secure and preoccupied pattern of attachment implies greater strength of attachment in relation to avoidant and fearful form of attachment. This finding indicates that adolescents who had positive model of other (attachment figure; i.e. mother, father, best friend) had significant more use of attachment system in relation with that figure, than adolescents who had negative model of other (the figure). 5) The findings suggest that during middle adolescence there is not either significant differentiation or generalization of attachment. These changes probably occurred in the transition from late childhood to early adolescence, and further changes of this kind should be examined in the late adolescence and early adulthood. Univerzitet u Nišu Filozofski fakultet Stefanović-Stanojević, Tatjana, 1963- Zlatanović, Ljubiša Zotović, Marija 1970- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1289 https://fedorani.ni.ac.rs/fedora/get/o:858/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1545007359 sr Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)

oai:eteze.ni.ac.rs:1290 2015-10-16T00:00:00Z 2

Diskurs srpske pravoslavne crkve o ženi i njen položaj u društvu : doktorska disertacija DISCURS SERBIAN ORTHODOX CHURCH OF WOMAN AND HER POSITION IN SOCIETY Simić, Žikica N. Žene, Srpska pravoslavna crkva, Ruska pravoslavna crkva, majka, društvo, emancipacija žene, porodica, sociologija, sociologija religije Serbian orthodox church, Russian orthodox church, woman, mother, society, emancipation of woman, family, sociology of religion The subject of this analysis is the woman and her social position promoted by Serbian orthodox church (and Russian orthodox church). It is well known that women have for centuries been systematicallz excluded from the sphere of public life and from position of power. Among the most influential factor promoting such a policz have been churches and religious communities, whose rules and interpretation imposed a patriarchal and authoritarian value system with a hierarchical power structure. It was important to examine what model of woomanhood promote SOC(and ROC), whether thez influence the system of values in serbian (and russian) society and process of social emancipation of womanor reflects the actual status of woman in society. The aim of the analysis is to find out, using qualitative methods content analysis, what roles, functions, qualities and attributes are ascribed to women (as girl, spouse and mother) with regard to man (as bozfriend, husband and father)in the discurs of SOC (and ROC). Univerzitet u Nišu Filozofski fakultet Gavrilović, Danijela 1967- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1290 https://fedorani.ni.ac.rs/fedora/get/o:860/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1545016063 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1297 2015-10-16T00:00:00Z 2

Osećaj porodične koherentnosti kod adolescenata : doktorska disertacija THE SENSE OF FAMILY COHERENCE AMONG ADOLESCENTS Minić, Jelena Lj. 1979- Psihologija adolescencije, porodična afektivna vezanost, porodična koherentnost, porodica adolescenta, društvena kriza, adolescenti, roditelji, porodica sense of family coherence, adolescents, parents, family The main point of this dissertation is to promote salutogenesis and Aaron Antonovsky's idea to search for the factors that promote health and not disease in the study of adolescents and their families, and to find the importance the salutogenic health model has, or may have in the preservation and improvement of health. The survey that was carried out is a continuation of the author's research conducted on a sample of families from Kosovo, with the aim of improving and strengthening the mental health of adolescents on their way to adulthood, on a practical level, with the involvement of experts. On the basis of the previous studies of sense of coherence on a sample of adolescents in our country, it is determined that there is a correlation with the variables included in this study. Considering the fact that the studies on the sense of family coherence are so rare (especially in our country), this study aims to improve the research scene on this problem. The results of the study, which was conducted for the last ten years on different age groups of people living in the territory of Kosovo and Metohija, point out a specific chronic social crisis in the region and the impact that living in conditions of social crisis can have on the individual aspects of personality. The object of this research, broadly defined, is the connection between a sense of family coherence among adolescents from Kosovo and Central Serbia (n = 360 adolescents, 15 to 24 years of age) and: family and partner affective attachment, self-esteem, age, family's financial situation, parents' level of education, vulnerability level in terms of the social crisis, strategies for proactive coping with stress, family satisfaction. The main issue of the research is to examine whether, in terms of a double crisis (developmental and social), the adolescents from Kosovo became ''victims'' or ''survivors'', what is the role of a sense of family coherence, and is the sense of coherence stronger among the younger or the older adolescents, among adolescent boys or adolescent girls. More precisely, the problem of the research is to examine whether there is a connection between a sense of family coherence among adolescents with: the degree of vulnerability of adolescents in terms of social crisis, family satisfaction (general and global), family affective attachment dimensions (avoidance and anxiety), models of partnership attachment (model of self and model of others), proactive coping, self-esteem, family's financial situation and parents' level of education; and whether there are differences in the intensity of the sense of family coherence in relation to some socio-demographic variables: place of residence, age, and adolescents' gender. This dissertation is salutogenic oriented, based on the salutogenic approach to health, i.e. on the salutogenesis and the feeling of coherence (Sagy and Antonovsky, 1992; Antonovsky and Sourani, 1988; Antonovsky, 1984). We focus on the sense of family coherence as one of the resources in the developmental and social crisis, which affects the health preservation and movement of the individual toward the positive pole of the health-illness continuum. Conducted research aimed to determine the connection between the sense of family coherence in adolescents, as an important resource in the developmental and social crisis, with the variables that were included in the study based on the settings of Aaron Antonovsky's salutogenic model of health. The survey used: Socio-Demographic Questionnaire for Obtaining Basic Data (constructed for the purposes of research), Questionnaire on the Degree of Vulnerability of the Individual in Terms of Social Crisis (Minic, 2009), The Family Sense of Coherence Scale (Antonovsky & Sourani, 1988), The Family Adaptation Scale (Antonovsky & Sourani, 1988), The Family Attachment Assessing Questionnaire (Brennan, Clark & Shaver, 1995), The Relationship Questionnaire – for the assessment of partner attachment (Bartolomew & Horowitz, 1991), The Proactive Coping Inventory (Greenglass et. al., 1999) and Self-Esteem Scale (Rosenberg, 1965). In the processing of data we used: descriptive statistics (frequencies and percentages, M and SD), correlation analysis, t-test, analysis of variance and regression analysis. The results of the research pointed put that there is a positive correlation between the sense of family coherence and family satisfaction, self-esteem, model of partnership affective attachment, proactive coping with stress and family's financial situation, and that there is a negative correlation between the sense of family coherence and the dimensions of family attachment (avoidance and anxiety). No statistically significant correlation between the sense of family coherence and the degree of vulnerability of the individual in terms of social crisis and the educational level of the father and mother was determined. The results also showed that there was a high positive correlation between the sense of family coherence of fathers and mothers, but no statistically significant correlation between the sense of family coherence in adolescents and a sense of family coherence of fathers and mothers. There are differences in the intensity of the feeling of family coherence in relation to the place of residence (Kosovo and Metohija, Central Serbia), age (middle and late adolescence) and adolescents' gender. Younger adolescents (15 to 19 years old) have a stronger sense of family coherence than older adolescents (20 to 24 years old). Intelligibility as a component of a sense of family coherence is more prominent among adolescents living in Kosovo and Metohija, compared to adolescents who live in Central Serbia. The results also point out that female participants in the study have a stronger sense of meaningfulness as a component of family coherence, compared to male participants. The sense of family coherence was stronger among adolescents with secure affective attachment styles, compared to adolescents with rejecting and fearful form of family affective attachment. Adolescents and their parents have adequate health resources, their mental health in terms of developmental and social crisis is not impaired thus preventive measures should be aimed at protecting and improving their health. The results of the research pointed out that the families of adolescents are an important source of a sense of family coherence and an important source of resistance in terms of developmental and social crisis. In addition, the results showed that the sense of family coherence at a family level is a good basis for further development and that is what makes a family an appropriate developmental environment for adolescents. The obtained data are consistent with most hypotheses and with the results of some previous studies. Univerzitet u Nišu Filozofski fakultet Stefanović-Stanojević, Tatjana Anđelković, Vesna Jerković, Ivan 1960- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1297 https://fedorani.ni.ac.rs/fedora/get/o:862/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533589910 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1304 2015-10-16T00:00:00Z 2

Epidemiološko ispitivanje moždanog udara i kvaliteta života obolelih u opštinama Doljevac i Despotovac : doktorska disertacija Antić, Ivan Moždani udar 1. Incidencija moţdanog udara u opštinama Despotovac i Doljevac je relatovno visoka u odnosu na razvijene zemlje sveta, Evrope, ali je niţa od incidencije registrovane u istoĉnoevropskim zemljama. IzmeĊu opština nije bilo razlike u stopi incidencije. 2. Osobe sa recidivom u ukupnoj populacije obe posmatrane opštine ĉinile su 20% obolelih lica. Pojava recidiva bila je sliĉna sa studijama u svetu. 3. U posmatranom periodu, trend oboljevanja i pojave recidiva u obe posmatrane opštine zabeleţio je pad. 4. Kod muškaraca obe posmatrane opštine zabeleţene su veće stope oboljevanja od moţdanog udara, kao i veće stope recidiva u odnosu na stope registrovane kod ţena. 5. Multivarijatna logistiĉka regresiona analiza potvrdila je sledeće faktore rizika za nastanak akutnog moţdanog udara: ateroskleroza, akutni i hroniĉni stres, neregulisana glikemija, povišene vrednosti lipida, povišen krvni pritisak. 6. Multivarijatna regresiona analiza izdvojila je hipertenziju i dijabet kao najznaĉajnije faktore rizika za nastanak recidiva moţdanog udara. 7. Nakon jednogodišnjeg perioda praćenja obolelih osoba od prvog moţdanog udara, kod 25% obolelih registrovan je potpuni oporavak kod 20% obolelih lica registrovan je letalitet, kod 55% ispitanika registrovan je invaliditet. Kod 40% obolelih sa invaliditetom registrovana je potreba za medicinskoj pomoći u kućnim uslovima, dok je 15% obolelim samcima bilo potrebno dostavljanje hrane. Razlike u ishodu bolesti izmeĊu obolelih osoba dveju opština nije bilo. 8. Nakon jednogodišnjeg perioda praćenja, obolelih osoba sa recidivom, smrtni ishod registrovan je kod 50% obolelih. Kod 10% obolelih registrovan je potpuni oporavak. Kod osoba sa invaliditetom, svega 15% obolelih bilo je sa lakšim stepenom invaliditeta, sa srednje teţim 45%, sa teţim 40% obolelih. Kod osoba sa invaliditetom bila je veća potreba za lekarskom pomoći u kućnim uslovima (45%); 30% obolelim osobama bilo je potrebno dostavljanje hrane. Razlike u ishodu bolesti obolelih sa recidivom izmeĊu opština nije bilo (p>0,05). 10. Kod osoba sa recidivom, nije bilo razlike u tipu predhodnog i ponovnog MU. 11. Na osnovu EQVAS upitnika, najbolje ocenjen kvalitet ţivota povezan sa zdravljem registrovan je u periodu 6 meseci nakon oboljenja, dok je najlošije ocena zdravlja registrovana u periodu mesec dana nakon oboljenja. 12. U periodu mesec dana pre oboljenja, u kontrolnoj grupi grupi registrovana je bolja pokretljivost, obavljanje uobiĉajne aktivnosti, manje problema o brizi o sebi, manji osećaj bola i nelagodnosti, brige i potištenosti, u odnosu na obolelu grupu. U kontrolnoj grupi registrovana je bolja ocena kvaliteta ţivota u posmatranom periodu. 13. Na osnovu EQVAS upitnika meĊu polova i opština nije bilo statistiĉke znaĉajne razlike u kvalitetu ţivota u svim fazama ispitivanja. 14. Na osnovu EQVAS i EQ5D upitnika, u svim fazama ispitivanja, kod maĊih ispitanika od 65 godina (u odnosu na starije od 65 godina), kod osoba sa prvim (u odnosu na osobe sa ponovnim), registrovan je bolji kvalitet ţivota nakon oboljenja. 15. U svim fazama ispitivanja, kod osoba sa ponovnim moţdanim udarom, registrovana je lošija pokretljivost, obavljanje uobiĉajnih aktivnosti, veći oseĉaj bola i nelagodnosti, brige i potištenosti, u odnosu na osobe sa prvim moţdanim udarom. 16. Na osnovu SF 36 upitnika tokom praćenja došlo je do poboljšanja opšteg zdravlja, subjektivne ocene zdravlja (u odnosu na period godinu dana od oboljenja), fiziĉkog zdravlja i fiziĉkog funkcionisanja, emocionalne uloge i mentalnog zdravlja. Poboljšanja socijalnog funkcionisanja i vitalnosti registrovano je tek u periodu godinu dana od oboljenja. 17. Najniţa ocena mentalnog zdravlja kod obolelih registrovana je u periodu mesec dana od oboljenja. U peroodu 6 i 12 meseci došlo je do poboljšanja mentalnog zdravlja. 18. Najniţe vrednosti fiziĉkog zdravlja registrovane su u periodu mesec dana od oboljenja. U periodi 6 meseci od oboljenja došlo je do poboljšanja fiziĉkog zdravlja. Univerzitet u Nišu Medicinski fakultet Petrović, Branislav, 1953- Kocić, Biljana Spasić, Mirjana Tiodorović, Branislav Blagojević, Ljiljana, 1952- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1304 https://fedorani.ni.ac.rs/fedora/get/o:864/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024516845 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1305 2015-10-16T00:00:00Z 2

Povezanost strukturnog obrasca, distribucije pigmenta i boje melanocitnih nevusa određenih metodom dermoskopije sa tipom kože i uzrastom : doktorska disertacija CORRELATION OF GLOBAL PATTERN, PIGMENT DISTRIBUTION AND COLOUR OF MELANOCYTIC NEVI DETERMINED BY DERMOSCOPY TO SKIN TYPE AND AGE Živković, Danica Tiodorović- Nevus MELANOCYTIC NEVI The use of dermoscopy increases clinical ability for differentiating of various types of melanocytic lesions and improves possibility of recognition of melanomas in their earliest stages. Different dermoscopic types of naevi could be recognized based on their structural characteristics, that is, on the quantity and distribution of pigments. Majority of people with multiple nevi have a predominant nevus type. Possible connection between a predominant melanocytic nevus and the age and/or skin phototype would enable easier recognition of dermoscopic patterns of unusual nevi for particular age and/or skin phototypes of patients which would in addition enable early recognition of melanoma. The aim of this research was to determine correlation of dermoscopic patterns, pigment distribution and colour of melanocytic nevi to age and skin phototype of patients. The research included 400 patients of the Clinic of Dermatovenerology in Niš, in the period from 2008 to 2012. A structural pattern was determined for each nevus, as well as its pigment distribution and colour. The link between dermoscopic characteristics was analysed in relation to age and skin phototype of patients. There were 6680 acquired melanocytic nevi which were analysed. A globular pattern was the most predominant among the youngest age group, while a reticular pattern showed significantly increased spread among the elderly. Central hyper/hypopigmentation revealed significant differences in frequency depending on skin phototype. Predominant dermoscopic patterns of melanocytic nevi depends on age of patients, whereas colour and pigment distribution depends on skin phototype. Univerzitet u Nišu Medicinski fakultet Jovanović, Dragan Spalević, Ljiljana Ilić, Ratko Stevanović, Goran Matić, Milan, 1968- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1305 https://fedorani.ni.ac.rs/fedora/get/o:865/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024513005 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1306 2015-10-16T00:00:00Z 2

Uticaj genske varijabilnosti adrenergičkih receptora i citohroma P450 oksidaze na farmakokinetiku i terapijsku efikasnost beta blokatora kod pacijenata sa srčanom insuficijencijom : doktorska disertacija Nikolić, Valentina 1970- Beta blokatori, Polimorfizam gena The beta-adrenergic receptor (β-AR) pathway is altered in heart failure. Recent studies have discovered functionally relevant and common polymorphisms in both β1-AR and β2-AR. These polymorphisms have been implicated with inconsistent results in the pathogenesis, clinical presentation, and prognosis of patients with heart failure (HF). In patients with HF, β-blockers reduce mortality. It’s not known whether the the response to β blockers in patients with HF could be associated with the genotype of drug-metabolizing enzymes and/or drug targets. We investigated the correlation of adrenergic receptor polymorphisms β1Ser49Gly, β1Arg389Gly and β2Arg16Gly with the risk of HF in Serbian population using a casecontrol study design. The genotype frequencies were in Hardy-Weinberg equilibrium. These polymorphisms were analysed by polymerase chain reaction-restriction fragment length polymorphism in patients with HF and compared with the control group. We also investigated the impact of 3 functional polymorphisms on survival, hospitalization and emergency department (ED) visits due to HF in carvedilol- and bisoprolol-treated HF patients. For these propose, 70 patients were enrolled and followed up at the HF clinic, and vital status was evaluated using electronic hospital and emergency department records and a local death certificate database. The aim of this study was to derive population pharmacokinetic (PK) model for clearance (CL) of carvedilol and bisoprolol, respectively in adult patients with HF using non-linear mixedeffect modeling (NONMEM). Finally, purpose of this study was to determine whether genetic polymorphisms in CYP2D6 correlated with dose of, or response to, bisoprolol or carvedilol treatment in patients with HF. Carvedilol and bisoprolol concentrations were quantified and effects on resting heart rate and blood pressure were analyzed using a multivariable clinical-genetic analysis. There were no differences or any trends in the allele and genotype frequencies of the β1Ser49Gly, β1Arg389Gly and β2Arg16Gly polymorphisms. None of these polymorphisms were associated with adverse outcomes (hospitalization, ED visits or mortality). There were significant CYP2D6 allele-specific differences in carvedilol pharmacokinetics, but the CYP2D6 genotype had no effect on heart rate and blood pressure. Our population pharmacokinetic (PPK) model for the clearance of carvedilol in routinely treated adult patients with CHF showed that the total body weight, concomitant therapy with digoxin and smoking tobacco were the main subjects of carvedilol pharmacokinetic variability. Finally, PPK model for the clearance of bisoprolol showed that the total daily dose of bisoprolol was the only important covariate. In conclution, β-blockers are the drugs where CYP2D6-related pharmacokinetic variation is apparently not carried forward into pharmacodynamic variation. Although current knowledge does not allow utilizing β1-AR and β2-AR genotypes for clinical treatment decisions, our data should stimulate further research on the impact of these genotypes in health and disease. Univerzitet u Nišu Medicinski fakultet Pešić, Srđan Stoimenov, Tatjana Jevtović- Ilić, Stevan 1946- Jović, Zorica Janković, Slobodan 1961- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1306 https://fedorani.ni.ac.rs/fedora/get/o:866/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024624621 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1307 2015-10-16T00:00:00Z 2

Značaj magnetne rezonance u dijagnostici kongenitalnih malformacija mozga : doktorska disertacija Value of magnetic resonance imaging in diagnosis of congenital malformations of the brain Marković, Ivana 1965- Mozak brain Congenital malformations of the brain are important cause of preterm newborns, children’s morbidity and mortality. The most common presentation of brain congenital malformations is developmental delay, mental retardation and epilepsy which are the main indications for neuroimaging exploration. MRI is radiological modality of choice for examination and diagnosis of the brain congenital malformations. Compromise between high-quality MR scans in pediatric neuroradiology and duration of MR examination is achieved through application of specific MR protocols which depend on child’s age and pathological findings. Based on the results, MRI protocols are proposed for optimal exploration of endocranial structures in pediatric patients and made possible to appropriately classify congenital malformations of the brain for further clinical evaluation, course and prognosis illness. Univerzitet u Nišu Medicinski fakultet Radovanović, Zoran Bošnjaković, Petar Stojanov, Dragan Stošić-Opinćal, Tatjana 1958- Živković, Miroslava 2012 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1307 https://fedorani.ni.ac.rs/fedora/get/o:867/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024507629 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1308 2015-10-16T00:00:00Z 2

Značaj prolongiranog ortoptičkog tretmana u rehabilitaciji binokularnog vida kod egzodevijacija : doktorska disertacija SIGNIFICANCE OF PROLONGED ORTHOPTIC TREATMENT IN REHABILITATION OF EXODEVITION BINOCULAR VISION Regoda, Vinko 1960- Očne bolesti EXODEVITION BINOCULAR VISION A good binocular vision is a requirement for proper sensorimotor relationship between two eyes. Impaired binocular cooperation and bulbomotornih muscle function can lead to sensory disturbances and the appearance of strabismus. Treatment of strabismus and amblyopia deserves a special becose of an early detection and timely treatment leads to elimination of monocular and binocular defects. Orthoptic evaluation of treatment the should provide the patient a pleasant and safe binocular vision. Present divergent strabismus with functional amblyopia requires orthoptic evaluation of treatment without delay. Any gaps in treatment would have resulted in the appearance of amblyopia and impaired binocular balance. Our study aimed to estimate the effects of prolonged orthoptic treatment on rehabilitation of binocular vision. In the case of divergent strabismus, with sensory abnormalities the prolonged treatment orthoptic evaluation can provide a good, comfortable binocular vision and lead to stabilization of sensor-motor relationships. Good orthoptic evaluation of treatment can significantly improve the oculomotor balance, stabilize binocular functions and in somecases lead to complete functional healing. . Analysing our study results, it can be concluded that prolonged treatment of orthoptic evaluation leads to improvement of binocular vision in children with exodeviation. Keywords: exodeviation, orthoptic evaluation of prolonged treatment, amblyopia, angle of deviation. convergence, the width of motor fusion, adduction, abduction. Univerzitet u Nišu Medicinski fakultet Veselinović, Dragan Zlatanović, Gordana Stefanović, Ivan 1964- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1308 https://fedorani.ni.ac.rs/fedora/get/o:868/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024665325 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1309 2015-10-16T00:00:00Z 2

Značaj kliničkih i biohemijskih parametara za tok, prognozu i kvalitet života bolesnika sa sistemskim eritemskim lupusom : doktorska disertacija The Significance of Clinical and Biochemical Parameters for the Course, Prognosis, and Quality of Life of Patients with Systemic Lupus Erythematosus Živković, Valentina 1965- Sistemski eritemski lupus, anti-C1q antitela, anti-nukleozomska antitela, monocitni hemoatraktant protein-1, lupusni nefritis anti-C1q antibodies, anti-nucleosome antibodies, monocyte chemoattractant protein-1, lupus nephritis, systemic lupus erythematosus Successful treatment and control of SLE requires precise assessment of disease activity and quality of life, as well as determination of biologic markers in order to administer proper therapy, to achieve disease remission, or to prevent or delay damage to the involved organs and treatment complications. This paper aimed to assess disease activity, degree of organ damage, and quality of life of SLE patients, using appropriate questionnaires and establishing their correlation; to determine the prevalence, specificity, and sensitivity of anti-nucleosome antibodies, anti-C1q antibodies, and serum and urinary monocyte chemoattractant protein-1 (MCP-1), and to identify their possible association with active forms of SLE and lupus nephritis. The studied group comprised 85 SLE patients, while 30 healthy examinees comprised the control group. In all examinees, in addition to standard clinical examination and supplementary diagnostic procedures, the levels of anti-nucleosome antibodies, anti-C1q antibodies, and serum and urinary MCP-1 were determined by way of the ELISA method. Disease activity was also assessed using the SLEDAI, ECLAM, and LAI questionnaires and by way of global physician assessment; organ damage was assessed using the SDI damage index, quality of life was assessed using the SF-36 questionnaire, and fatigue severity was measured using the FSS fatigue scale. Based on the completed study, a conclusion may be drawn that disease activity did not correlate with organ damage, quality of life, and fatigue severity. Anti-C1q antibodies and simultaneous positivity of anti-nucleosome, anti-C1q and anti-dsDNA antibodies were associated with lupus nephritis activity. Urinary MCP-1 demonstrated a highest association with active lupus nephritis forms, being in high positive correlation with the degree of proteinuria and in negative correlation with glomerular filtration rate. Univerzitet u Nišu Medicinski fakultet Stanković, Aleksandra Cvetković, Tatjana 1965- Vujasinović-Stupar, Nada 1955- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1309 https://fedorani.ni.ac.rs/fedora/get/o:869/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024663021 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1317 2015-10-16T00:00:00Z 2

Komparativna analiza rezultata lečenja trohanternih preloma : doktorska disertacija THE COMPARATIVE ANALYSIS OF THE RESULTS ACHIEVED IN THE TROCHANTERIC FRACTURE TREATMENT Todorović, Momčilo 1960- Trohanter TROCHANTERIC FRACTURE This doctoral thesis deals with the current problem of osteoarticular system and trochanteric fracture treatment of people who are 60 or more years old. The fracture is treated by extramedular implants, DHS-YU, selfdynamizing fixator-Mitkovic and DHS-Richards. The thesis contains both experimental and clinical part of study. In the experimental part of the thesis, you can find a research carried out on biomechanic characteristics of the implants and dinamization at the axis neck under cyclic loading. Wooden femur models with virtual trochanteric fracture are used (under fracture corner of 45º) and they are fixed with a corresponding implant. At the Faculty of Engineering in Nis, a research was carried out with a specific instrument used for cyclic examination. It has been used for the implant testing since 2007. Wooden femur models are used for testing the implant resistence on the axial force. As an equipment part, we used a “twitcher” (Veb Thuringer Raunsteim). During the procedure we used power of 1000N. One hundred and fifty patients who were 60 or more years old, took part in the clinical prospective study.They all had a trochanteric fracture and were all treated with the dynamic extramedular implant, DHS-YU, self-dynamizing fixator-Mitkovic and DHS-Richards, at the orthopedic ward in Cuprija and at the orthopedic clinical ward in the Health Center in Nis. The research period lasted from January 1st 1995 to June 1st 2010. The following parameters were recorded: the patients’ sex and age, fracture type and operation duration, blood compensation, application of antibiotics, pain, range of movement, muscle power, verticalization time, curtailment of the limb operated on, patients’ walk and activity after operation. Mechanic complications, superficial and deep infections, duration of hospitalization, mortality and final functional results were also recorded. The final treatment results were estimeted with Salvati-Wilson scale modified by Todorovic and Jevtic. The author has come to conclusions which are reliable and applicable. Momčilo Todorović – Doktorska disertacija Komparativna analiza rezultata lečenja trohanternih preloma - 187 - During the test of dynamization of the neck axis with cyclic loading applied on the femur model, the dynamization happens in an early phase in the case of all the three implants. During the testing process of the continual axial force at 1000N, none of the implants’ plastic is deformed. Apart from dynamization in the neck axis, existing in all the three extramedular implants, dynamization along the axis of the femur, existing in the selfdynamizing inner fixator-Mitkovic, has an advantage when we compare it with the other extramedular implants. According to the clinical research results, in the treatment of femur trochanteric fracture with dynamic extramedular implants (DHS-YU, selfdynamizing inner fixator Mitkovic, DHS-Richards) we can say that all the implants are anatomically and functionally very efficient. The treatment of trochanteric fractures treated with DHS-YU implants compared with the treatment of trochanteric fractures treated with DHS-Richards implants, shows that better results are achieved with DHS-implants if we consider patients’ supporter,walk and activity after operation. It has been confirmed that there is no great statistic difference in the analyzed parameters between patients who are treated with DHS YU extramedular implant and patients treated with selfdynamizing inner fixator – Mitkovic. The study results are very important for trochanteric fracture treatment applied on older patients. Univerzitet u Nišu Medicinski fakultet Golubović, Zoran, 1957- Mitković, Milorad Ristić, Branko 1962- Micić, Ivan Milenković, Saša 1965- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1317 https://fedorani.ni.ac.rs/fedora/get/o:870/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024531437 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1318 2015-10-16T00:00:00Z 2

Analiza sistemskih efekata inflamacije i težine bolesti kod obolelih od hronične opstruktivne bolesti pluća : doktorska disertacija Analysis of systemic effects of inflammation and disease severity in patients suffering from chronic obstructive pulmonary disease Ćirić, Zorica 1958- Hronična opstruktivna bolest pluća pulmonary disease There is an abnormal inflammatory pulmonary response to harmful particles or gases in chronic obstructive pulmonary disease (COPD). Pulmonary inflammation spills over into systemic circulation which causes extra pulmonary manifestations. A large number of inflammatory mediators are involved in establishing and maintaining of inflammatory response. The aim of the research was the analysis of systemic effects of inflammation and COPD severity. The examination was done in the Clinic for Pulmonary Diseases Knez Selo, Clinical Center Niš, and it involved 85 patients with COPD in a stable phase. The patients were divided into four groups: mild, moderate, severe and very severe COPD. Serum values of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and leptin were measured, BODE index was determined, and the presence of weight loss and muscle loss, muscle dysfunction and osteoporosis were determined. We found that with the increase in COPD severity, values of CRP, TNF-α and leptin varied in the range that was not statistically significant. CRP had positive, and TNF-α negative predictive influence on COPD severity. The increase in disease severity was followed by borderline statistically significant increase in frequency of underweight and borderline nutrition (p=0.05). Leptin values of underweight and normal nutrition were significantly different from leptin values of pre-obese and obese (p<0.000). Increase in disease severity was followed by significant decrease in effort tolerance (p<0.000) and increase in dyspnoa (p<0.000). We found significant negative correlation between 6MWT and COPD severity. Bone Mineral Density (BMD) was significantly decreased when COPD severity was increased (p=0.26). Osteoporosis had significant negative predictive effect on disease severity. We determined that with increase in BODE index values of CRP, TNF-α and leptin varied in the range that was not statistically significant, and that CRP had significant positive, and TNF-α negative correlation with BODE index values. It was found that with increase in BODE index the number of underweight patients was significantly increased (p<0.019) along with the frequency of osteoporosis (p=0.05), and the effort tolerance was significantly decreased (p=0.000), while dyspnoa was increased (p=0.000). In conclusion, we may say that increase in COPD severity is followed by increase in systemic effects, and that BODE index is a good indicator of disease severity and systemic effects of COPD. Univerzitet u Nišu Medicinski fakultet Stanković, Ivana Ristić, Lidija Rančić, Milan Lazić, Zorica 1956- Pejčić, Tatjana 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1318 https://fedorani.ni.ac.rs/fedora/get/o:871/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024529645 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1319 2015-10-16T00:00:00Z 2

Uloga duodenogastričnog refluksa u nastanku prekanceroznih lezija želuca i antirefluksna uloga Roux-en-Y vijuge kao metode izbora u njegovoj prevenciji : doktorska disertacija Zlatić, Aleksandar V. Duodenogastrični refluks, Želudac Već od prvih opisa duodenogastriĉnog refluksa pre oko 200 godina, lekari su bili zainteresovani da utvrde njegovu ulogu u nastanku poremećaja gornjeg dela gastrointestinalnog trakta. Iz velike grupe postresekcionih sindroma, prvobitno su izdvojeni Dumping sindrom, sindrom odvodne vijuge, sindrom malog ţeluca, sindrom loše apsorpcije a tek u novije vreme, kao poseban entitet, izdvaja se postoperativni refluks gastritis i usporeno praţnjenje ţeluca. Duodenogastriĉni refluks (DGR), enterogastriĉni refluks (EGR), refluks ţuĉi ili alkalni refluks gastritis, postresekcioni gastritis, sinonimi su za istu pojavu koja se moţe definisati kao ''vraćanje duodenalnog sadrţaja kroz nekompetentnu piloričnu valvulu iz duodenuma u ţeludac, odnosno duodenuma i tankog creva preko anastomoze u ţeludac'' (1). Poznavanje postresekcionih gastritisa, kao i gastritisa uopšte, sadrţi i danas mnogo praznina. Uopšte uzev, kod ĉoveka se javljaju dve vrste hroniĉnog gastritisa: jedan koji je udruţen sa sa prisustvom cirkulišućih antitela na parijetalne ćelije i unutrašnji faktor (autoimuni gastritis), i drugi, za nas znaĉajniji, koji nije praćen pojavom antitela protiv sopstvene sluznice. Ovaj drugi oblik atrofiĉnog gastritisa, kao dokazanog prekanceroznog stanja patogenetski se vezuje za agresivno dejstvo duodenogastriĉnog refluksa ili za pad hormonske stimulacije celularne mitoze ţeludaĉne sluznice usled iskljuĉenja antruma(2). Van Heerden i saradnici, prvi put primenjuju termin ''postoperativni alkalni gastritis'' smatrajući da je za refluks gastritis glavni patogenetski faktor alkalni sadrţaj duodenalnog soka(3). Uporedo sa prethodnim mišljenjem razvijala se i dokazivala biliogena teorija refluks gastritisa koja se zasniva na eksperimentalnim radovima Davenporta i sar (4): oni tvrde da su ţuĉ i ţuĉne soli u stanju da onemoguće ţeludaĉnu sluznicu da zadrţi vodonikove jone u lumenu ţeluca. Isti autor je predloţio hipotezu retrogradne difuzije H+ jona kao mogućeg inicijalnog faktora u mehanizmu nastanka gastritisa. Ulazak H+ jona iz ţeludaĉnog lumena u gastriĉnu sluznicu omogućen je delovanjem ţuĉi na mukoznu barijeru saĉinjenu od mukusnog sloja, ćelijske membrane, intercelularnih granica i zidova kapilara. Vodonikovi joni koji se nalaze u lumenu ţeluca, suprotno gradijentu koncentracije, ponovo ulaze u sluznicu, zamenjuju natrijumove jone iz intersticijuma i prodiru u ćelije iz kojih izlaze kalijumovi joni. Nagomilavanje vodonikovih jona u ćelijama vodi intracelularnoj acidozi koja koĉi metabolizam ćelije i, na kraju, dovodi do propadanja ćelije. Ţuĉ koja je prodrla u intersticijum ţeludaĉne sluznice, svojim deterdţentskim dejstvom omogućuje prodor histamina koji u kontaktu sa krvnim sudovima izaziva vazodilataciju i povećanu propustljivost zidova, što izaziva kongestiju i edem. (4) Izraz ,,postoperativni alkalni gastritis” se već odomaćio u literaturi, mada se na osnovu prethodno iznešene teorije dovodi u pitanje ĉinjenica da je alkalnost refluksnog sadrţaja uzrok oštećenja ţeludaĉne sluznice i sugeriše da je najpodesniji izraz ''postoperativni refluks gastritis''(5). Duodenogastriĉni refluks se sreće posle gastroenteroanastomoze, sa ili bez resekcije ţeluca (Billroth I, Billroth II), posle vagotomije i piloroplastike, gastroduodenostomije, kao i kod neoperisanih bolesnika. Gastroenteroanastomozom u resekciji tipa B II i odstranjivanjem pilorusa u resekciji tipa B I stvaraju se uslovi za nastanak stalnog refluksa duodeno-biliopankreatiĉnih sokova u ţeludac, ĉijim delovanjem nastaju zapaljenskodistrofiĉno- metaplastiĉke lezije ţeludaĉne sluznice i konsekutivno oštećenje njene fiziološke funkcije a samim tim i stvaranje uslova za nastanak drugih oboljenja (6). U nastajanu prekanceroznih lezija, pored ţuĉnih soli i ţuĉnih kiselina, poseban znaĉaj pridaje se i ostalim faktorima mikrosredine ţeluca: smanjenju gastriĉnog aciditeta (hipohlorhidrija i ahlorhidrija), pojavi bakterija u lumenu ţeluca i prisustvu nitrata i nitrita a, posebno, N-nitrozojedinjenjima (7). Kancerogena svojstva N-nitrozo jedinjenja , poznata su već duţe vreme. Mogućnost nastajanja N-nitrozo jedinjenja dokazana je i in vitro i in vivo u ţelucu eksperimentalnih ţivotinja, nekancerogenih sekundarnih i tercijarnih amina i amida prisutnih u hrani, kao i azotaste kiseline, odnosno, nitrata i nitrita prisutnih u vodi za piće. N-nitrozo jedinjenja mogu nastati i iz nitrita i nekih lekova, kao što su antihistaminici, trankilizeri, disulfram, antibiotici. Neki autori posebno istiĉu opasnost nastajanja N-nitroznih jedinjenja kod dugotrajno tretiranih pacijenata nekim antagonistima H2 receptora (cimetidin, ranitidin), jer je cimetidin derivat guanina i u prisustvu nitrita lako se transformiše u mononitro- cimetidin, koji je analog MNNG-u (8). Treba imati u vidu da su ovi lekovi i dalje u širokoj upotrebi, i pored postojanja inhibitora protonske pumpe (omeprazola, esomeprazola i dr.). Univerzitet u Nišu Medicinski fakultet Jeremić, Miroslav Stojanović, Miroslav Višnjić, Milan Mihailović, Dragan 1954- Veljković, Radovan 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1319 https://fedorani.ni.ac.rs/fedora/get/o:872/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024529389 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1321 2015-10-16T00:00:00Z 2

Specifičnosti kraniofacijalne morfologije pacijenata sa asimetrijom lica skeletnog porekla : doktorska disertacija Specific characteristics of craniofacial morphology of patients with facial asymmetry of skeletal origin Stošić, Maja Kosti lica craniofacial morphology, facial asymmetry PhD thesis „ Specific characteristics of craniofacial morphology of patients with facial asymmetry of skeletal origin is original and indipendent scientific research in the field of orthopeadics of the jaws. It is the study of facial asymmetry of skeletal origin in patients in our region. It confirmed that facial asymmetries of skeletal origin have specific dentalveolar and skeletal characteristics whose detailed analysis, applied ih this thesis, improves and enables more completly therapy planning of this dentofacial deformities. Univerzitet u Nišu Medicinski fakultet Janošević, Mirjana 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1321 https://fedorani.ni.ac.rs/fedora/get/o:873/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024537581 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1322 2015-10-16T00:00:00Z 2

Komparativna analiza primene longitudinalnog dorzalnog i lateroventralnog dartos flapa u prevenciji komplikacija operativnog rešavanja distalnih i srednjih hipospadija snodgrass tehnikom : doktorska disertacija COMPARATIVE ANALYSIS OF LONGITUDINAL DORSAL AND LATEROVENTRAL DARTOS FLAP IN COMPLICATIONS PREVENTION IN SURGICAL TREATMENT OF DISTAL AND MIDSHAFT HYPOSPADIAS USING SNODGRASS TECHNIQUE Izairi, Asim 1968- Hipospadija hypospadias, Snodgrass technique, dartos flap, complications Background: Hypospadias is the most common congenital anomalies of the male genitalia. Objective: The objective of this study was to assess the role of longitudinal dorsal and lateroventral dartos flap for prevention of complications in surgical treatment of distal and midshaft hypospadias using Snodgrass technique. Material and methods: The study was conducted as a prospective, controlled, open study and included 116 boys of age 11 months to 7 years, with distal and midshaft hypospadias. The patients were divided into two groups, Group A and Group B, with 40 patients each, and a control group, Group C with 36 patients. A preoperative protocol was completed before the patients underwent surgical treatment applying Snodgrass technique. In Group A longitudinal dorsal flap was prepared by deepithelization of hipospadiac prepuce and dorsal penile shaft skin, using the "button-holed" maneuver, hence covering neourethra. In Group B in order to cover neourethra, lateroventral subcutaneous flap was prepared by deepithelization of lateral penile shaft skin and prepuce, whereas no flap was used in the control Group C. Postoperative complications, in particular appearance of urethtrocutaneous fistula were analyzed in follow-up periods of 1, 3 and 6 months. Results: In Group C where no flap was used, the occurrence of fistula was 16,7% with a statistically significant difference (p=0,007) to Group A and Group B where secondary dartos flap was used. Also it was found a statistically significant difference in postoperative penile torsion, more frequent in Group B where lateroventral flap was used in contrast to Group A, where longitudinal dorsal flap dartosa was used (p=0,04). No statistically significant differences were found among the groups when stenosis of the meatus, urethral stricture, oedema, bleeding, hematoma, and other complications were assessed. The overall success rate of surgery in Group A was 96,2%, in Group B 94,1%, and in Group C 86,1%. Conclusion: Based on this study, the following conclusions were made: a) the use of longitudinal dorsal subcutaneous flap and lateroventral subcutaneous flap in surgical treatment of distal and midshaft hypospadias using Snodgrass technique provides a maximum prevention of fistula formation; b) longitudinal dorsal subcutaneous flap is compatible with the anatomical longitudinal direction of the penis, therefore it prevents postoperative penile torsion; c) lateroventral subcutaneous flap provides additional support for prevention of fistula formation, but it may cause postoperative penile torsion; d) Snodgrass urethroplasty represents a versatile, simple, and a single-stage technique in surgical treatment of distal and midshaft hypospadias, with minimal postoperative complications rate and excellent functional and cosmetic results Univerzitet u Nišu Medicinski fakultet Slavković, Anđelka 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1322 https://fedorani.ni.ac.rs/fedora/get/o:874/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024537325 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1330 2015-10-16T00:00:00Z 2

Uloga svetlosno polimerizujućih i adhezivnih tehnika u proceni marginalne adaptacije kompozitnih smola za gleđ i dentin : doktorska disertacija THE IMPACT OF LIGHT CURING AND ADHESIVE TECHNIQUE ON MARGINAL ADAPTATION OF COMPOSITE RESINS TO ENAMEL AND DENTIN Dačić, Stefan D. 1978- Stomatološki materijali, kompozitne smole, adhezivi, gleđ, dentin, fotoaktivacija, genotoksičnost composite resin, adhesives, enamel, dentin, photoactivation, genotoxycity Introduction The quality of bond between composite and hard dental tissue is most commonly estimated on the basis of strength of bond or absence of marginal gap along restoration border. Marginal index (MI) is a significant indicator of the efficiency of the bond between material and dental tissue because it also shows the values of width and length of marginal gap. The aim of this paper was to estimate quantitative and qualitative features of the bond between composite resin and enamel and dentin, and to determine the values of MI in enamel after application of two techniques of photopolymerization of composite and two composite adhesive systems. Also, the impact of longevity of photopolimerization on genotoxicity of composite adhesives has been investigated. Material and methods Forty Class V cavities were prepared and restored for scanning electron microscope (SEM) analysis of composite bonding to enamel and dentin. Adhesion to enamel and dentin was secured by etch and rinse procedure (adhesive-Adper Single Bond 2-ASB/3M ESPE), i.e. by self etch primer/adhesive (Adper Easy One-AEO/3M ESPE). Photopolymerization of composite resin (Filtek Ultimate-3M ESPE) was performed using standard halogen light or gradually, using soft start program. Genotoxyciti of adhesives was invastigated using Comet assay. Results The smallest average MI was determined with gradual light curing and application of ASB/FU material. Qualitative analysis showed better marginal adaptation after application of etch and rinse adhesive technique and gradual light curing, compared to self etch adhesive technique and standard photoactivation. Dentin did not show significant differences in the bond between composite restorations and dentine tissue compared to light curing technique but significant difference were determined with respect to the type of adhesive composite material (adhesive technique). Dentin also 108 showed a better quality of the composite bond with etch and rinse adhesive technique, regardless of light curing technique. Using Comet assay it was concluded that significant lower genotoxicity showed both adhesives after photopolymerization in duration of 40 seconds compared to 10 seconds. Conclusion The best marginal adaptation of composite (lowest MI) to enamel and dentin was obtained with gradual soft start photoactivation in etch and rinse adhesive technique and ASB/ FU material. The best marginal adaptation of composite (lowest MI) for dentin was also determined with etch and rinse adhesive technique and the same material, regardless of photopolymerization technique. Longer duration (40 sek) of photoactivation of adhesives in regard to recommendations of manufactures (10 sek.) contributs to lowering of their genocitotoxicity. Univerzitet u Nišu Medicinski fakultet Radičević, Goran Tošić, Goran Mitić, Aleksandar Živković, Slavoljub, 1958- Đelić, Ninoslav, 1962- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1330 https://fedorani.ni.ac.rs/fedora/get/o:875/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024540653 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1332 2015-10-16T00:00:00Z 2

Izbor rekonstruktivne procedure nakon totalne gastrektomije zbog karcinoma želuca : doktorska disertacija The choice of reconstructive procedures after total gastrectomy for gastric cancer Ignjatović, Nebojša 1967- Rekonstruktivna hirurgija, gastrektomija, karcinom želuca gastric cancer, gastrectomy, reconstructive procedures Stomach cancer is the most common neoplasm of the gastrointestinal tract. Although the incidence of gastric cancer in recent decades been steadily decreasing, it is still the second largest cause of mortality in the world. The survival rate after total gastrectomy for gastric cancer has been improved thanks to early diagnosis and improved operational techniques. After total gastrectomy and systemic lymphadenectomy, many reconstructive techniques have been developed in an effort to minimize the symptoms resulting loss of gastric function, improve physiological and nutritional status of the patient's rapid return to normal daily activities. At the same time, gastric reconstruction method should be technically easy to perform with minimal postoperative complications. Most patients after total gastrectomy develop symptoms postgastrectomy syndrome, dysphagia, heartburn, reflux esophagitis, diarrhea and weight loss. Reduced transit time through the intestine chyme is blamed as the main cause of malassimilation nutrient nutrients. Nutrient deficiencies may occur as a consequence of disturbed digestion and absorption of protein, fat and liposoluble vitamins that can affect pancreatico-cibal asynchrony and lack of bile acids. Especially notable is the decreased absorption of micronutrients, which are mainly absorbed in the duodenum, such as calcium and iron. The rapid transit of food through the intestine, also reduces the absorption of calcium, while the presence of steatorrhea leads to the formation of insoluble calcium soaps which can contribute calcium malabsorption. After total gastrectomy postgastrektomijska often develop bone disease in the form of osteomalacia or osteoporosis because of lower level of calcium and 25- (OH) vitamin D levels. Iron deficiency, vitamin Bn (cyanocobalamin) deficiency and folic acid deficiency in the postoperative period after total gastrectomy causes the emergence of different forms of anemia. In most patients after total gastrectomy developed excessive bacterial colonization due to lack of stomach „acid barrier,, and chyme stagnation in the afferent jejunum limb, leading to the syndrome of bacterial growth: malabsorption of fats, carbohydrates, protein and micronutrients. Preservation of duodenal passage of food reconstructive procedures should improve the absorption of these nutrients, even in other intestinal segments. Therefore, in order to alleviate the symptoms of postgastrectomy syndromes and improved postoperative quality of life, access to a variety of reconstructive procedures. Since it is relatively simple to perform, it switches the esophagus and jejunum, and may prevent reflux esophagitis, Roux-en-Y reconstruction is the most common reconstructive procedure that is performed after total gastrectomy. However, many researchers have pointed to the importance of the reservoir function of the stomach and duodenum through the passage of food, and the presence of duodenal passage. Therefore, have been developed and reconstructive procedures with preservation of duodenal passage interposition between the esophagus and duodenum, respectively, reconstruction esophagojejunostomy Roux-en-Y configuration „double tract,, isoperistaltic interposition and free jejunal segment by the method of Longmire’s. Quality of life after total gastrectomy is an important fact outcomes postoperative course. Preservation of duodenal passage of reconstruction after total gastrectomy results in better physiological mixture chyme with bile and pancreatic juice, normalization of physiological regulation of gastrointestinal hormones and adequate intestinal motility by down regulating or decrease the incidence of occurrence postgastrectomy syndrome. Reconstruction after total gastrectomy for gastric cancer with duodenal passage preservation of an optimal choice in establishing esophagus-intestinal continuity and improvement of postoperative quality of life of patients. Univerzitet u Nišu Medicinski fakultet Stojanović, Miroslav Jeremić, Miroslav Ranđelović, Tomislav 1953- Nagorni, Aleksandar Stanojević, Goran 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1332 https://fedorani.ni.ac.rs/fedora/get/o:876/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024517357 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1333 2015-10-16T00:00:00Z 2

Komparativna analiza homeostaze kalcijuma u uslovima fiziološke i medikamentne hiperprolaktinemije : eksperimentalna studija : doktorska disertacija Radojković, Danijela 1971- Hiperprolaktinemija Na osnovu rezultata ovog eksperimenta, može se zaključiti da je genska ekspresija prolaktinskih receptora, u ciljnim organima homeostaze kalcijuma, značajno različita u fiziološkoj i medikamentnoj hiperprolaktinemiji. U fiziološkoj hiperprolaktinemiji potvrđena je signifikantno viša ekspresija PRLR u duodenumu, što je u saglasnosti sa rezultatima dosadašnjih istraživanja. Istovremeno je, po prvi put, u uslovima fiziološke hiperprolaktinemije, verifikovana signifikantno niža ekspresija PRLR u bubregu i pršljenovima. U medikamentnoj hiperprolaktinemiji, istraživanja u domenu genske ekspresije PRLR do sada nisu sprovedena. Rezultati ovog eksperimenta, po prvi put, otkrivaju značajno sniženu ekspresiju PRLR u duodenumu, a povišenu u bubregu i pršljenovima. Ovako različita genska ekspresija PRLR, u target organima metabolizma kalcijuma, u uslovima fiziološke i medikamentne hiperprolaktinemije, objašnjava rezličite mehanizme homeostaze kalcijuma. U stanju fiziološke hiperprolaktinemije, viša ekspresija PRLR u duodenumu dovodi do povećane intestinalne apsorpcije kalcijuma, a snižena ekspresija PRLR u pršljenovima sprečava resorpciju kalcijuma iz skeletnog sistema. U medikamentnoj hiperprolaktinemiji, niska ekspresija PRLR u duodenumu praćena je smanjenom apsorpcijom kalcijuma, povišena ekspresija PRLR u bubregu rezultuje povišenom kalcijumurezom, a viša ekspresija PRLR u pršljenovima dovešće do povećane koštane resorpcije kalcijuma. Kao posledica različite homeostaze kalcijuma, promene koje trpi koštani sistem u fiziološkoj hiperprolaktinemiji, su blage i reverzibilne, dok se medikamentna hiperprolaktinemija može smatrati značajnim faktorom rizika za gubitak koštane mineralne gustine. Na osnovu postavljenih hipoteza i rezultata ovog eksperimentalnog rada mogu se izvesti sledeći zaključci: I. U stanju fiziološke hiperprolaktinemije verifikovana je značajno viša ekspresija PRLR u duodenumu, što omogućuje povećanu intestinalnu apsorpciju kalcijuma. Značajno niža ekspresija PRLR u pršljenovima ostavlja manje prostora za resorpivno dejstvo PRL i time štiti skeletni sistem od gubitka kalcijuma. II. U medikamentnoj hiperprolaktinemiji dolazi do nishodne regulacije ekspresije PRLR u duodenumu, čime se gubi značajna uloga prolaktina u apsorpciji kalcijuma iz intestinuma. Tražeći drugi izvor kalcijuma, koji bi nadomestio smanjenu intestinalnu apsorpciju, prolaktin se okreće koštanom sistemu, odakle ubrzano crpi kalcijum zahvaljujući ushodnoj regulaciji PRLR u pršljenovima. III. Blagovremeno uključivanje suplementne terapije kalcijumom i vitaminom D, dovodi do značajno više ekspresije PRLR u duodenumu pacova sa prolongiranom hiperprolaktinemijom, čime se može oporaviti intestinalna apsorpcija kalcijuma Univerzitet u Nišu Medicinski fakultet Antić, Slobodan Pešić, Milica Đorđević, Vidosava Jevtović-Stoimenov, Tatjana Micić, Dragan 1950- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1333 https://fedorani.ni.ac.rs/fedora/get/o:877/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024529133 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1337 2015-10-16T00:00:00Z 2

Opšti tip stabilnosti stohastičkih funkcionalnih diferencijalnih jednačina : doktorska disertacija GENERAL DECAY STABILITY OF STOCHASTIC FUNCTIONAL DIFFERENTIAL EQUATIONS Pavlović-Rajković, Gorica A. 1979- Matematika, Gaussov beli šum, metoda Razumikhina, Lyapunova metoda, Brownovo kretanje (Wienerov proces) Stochastic processes, differential equations, stability In this thesis, pth moment and almost sure stability on a general decay rate for several types of stochastic functional differential equations were studied. By applying Razumikhin method and Lyapunov method stability criteria were obtained. Having in mind that some types of stochastic differential equations are not exponentially stable, the information about the stability with respect to a certain lower decay rate is very important, which was the motive for research in this paper. Some future research could focus on application of Krasovskii-Lyapunov method for exploring the general decay stability of the already studied types of stochastic differential equations. In this way, we could get different stability and decay rate criteria with respect to those obtained in the thesis. The research based on the modified results of this thesis could be continued for studying stability of various classes of stochastic functional differential equations with respect to martingale and martingale measures. The research on pth moment and almost sure stability and pth moment instability on a general decay rate for stochastic functional differential equations with Markovian switching and delayed impulses could be extended to stochastic differential equations with random impulses and Markovian switching which more realistically describe processes impulsive in kind. Also, Razumikhin method and Lyapunov method could be applied in studying pth moment and almost sure stability on a general decay rate for hybrid impulsive stochastic differential equations with switching not defined by Markov chain law as well as stochastic neural networks. Moreover, these methods could be used for studying general decay stability of all the above mentioned types of impulsive stochastic differential equations with respect to martingale and martingale measures. Some future research could be based on the application of LMI theory results to studying pth moment and almost sure stability on a general decay rate of perturbed impulsive stochastic functional differential equations with Markovian switching and hybrid perturbed impulsive stochastic functional differential equations. Univerzitet u Nišu Prirodno-matematički fakultet Janković, Svetlana 1949- Petrović, Ljiljana 1956- Jovanović, Miljana 1965- Milošević, Marija 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1337 https://fedorani.ni.ac.rs/fedora/get/o:878/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024759017 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1338 2015-10-16T00:00:00Z 2

Uticaj dijamagnetnih dvovalentnih jona metala na autooksidaciju vicinalnih trihidroksilnih fenolnih jedinjenja u vodenim rastvorima : doktorska disertacija The influence of divalent diamagnetic metal ions on vicinal trihydroxy phenolic compounds autoxidation in aqueous solutions Veselinović, Aleksandar M. 1978- Vodeni rastvori, pirogalol, galna kiselina, etil-galat autoxidation, pyrogallol, gallic acid, ethyl-gallate, diamagnetic metal ions In this dissertation the influence of divalent diamagnetic metal ions (Mg(II), Ca(II), Sr(II), Ba(II), Zn(II), Cd(II) and Pb(II)) on vicinal trihydroxy phenolic compounds autoxidation in aqueous solutions was examined. Autoxidation processes of pyrogallol (the simplest compound with appropriate structure), gallic acid and ethyl gallate were studied with the application of UV/Vis spectrophotometry with chemometric data processing, EPR spectroscopy, High-performance liquid chromatography (HPLC) and Mass spectrometry (ESI-MS). It was determined that pH value of solution and presence and type of diamagentic metal ions have great influence on investigated compounds autoxidation processes rates and mechanism. With the aid of applied techniques the structures of transition free radical species and stable autoxidation processes products were determined. Obtained results enabled better understanding of investigated compounds autoxidation processes which is of great importance since gallic acid is found in many plants, while ethyl gallate is used as an antioxidant in food. Univerzitet u Nišu Prirodno-matematički fakultet Nikolić, Goran M. 1966- Nikolić, Ružica 1951- Kostić, Danijela 1969- Nikolić, Vesna 1965- Živković, Jelena 1971- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1338 https://fedorani.ni.ac.rs/fedora/get/o:879/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024720873 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1340 2015-10-16T00:00:00Z 2

Permutacije sa ograničenjima : doktorska disertacija Restricted permutations Baltić, Vladimir M. 1973- Matematika, permutacije, kombinacije, particije, kompozicije enumeration combinatorics; permutations, exact enumeration, recurrence equations, permanents, finite state automata In this thesis we study different methods of counting a large number of combinatorial objects: permutations, variations, combinations, subsets, with some additional restrictions. We have developed a completely new method for the enumeration of some of these objects and make connections among some of them. We estimate the algorithmic complexity of the new method and analyze what is better than existing ones. We have entered a hundred new sequences in Slone’s Online encyclopedia of integer sequences and provided comments on the large number of existing sequences. Univerzitet u Nišu Prirodno-matematički fakultet Stevanović, Dragan 1974- Ilić, Snežana 1954- Simić, Slobodan 1948- Petrović, Vojislav 1951- Dobroslovački, Rade 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1340 https://fedorani.ni.ac.rs/fedora/get/o:880/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024755433 sr Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)

oai:eteze.ni.ac.rs:1345 2015-10-16T00:00:00Z 2

Restrukturiranje bankarskog sektora i doprinos privrednom razvoju u tranzicionim uslovima : doktorska disertacija Banking sector restructuring and contribution to economic development in transition conditions Brković, Milan 1973- Bankarski sektor Banking sector, transition Paper focuses on banking sector restructuring and influences on economic development in transition countries. Liberalization of financial markets together with abandon of central plan principle lead to significant changes in banks ownership structure, independence in economic rational decisions while extended a loan, new asset and liability management and domination of foreign banks. Broadness and deepness of requested changes in banking sector consequently influenced agility of reforms and had direct impact on economic growth and development. Countries with faster and more efficient reforms implementation in banking sector achieved faster economic growth. Relative share of financial sector in total output of the country constantly grew but direct impact on production is also important. Reformed banking sector brought back trust in banks which in turn lead to savings rate and all together contributed to the new role of banks in transition or market oriented business like in any other modern banking system. Nevertheless, further steps are expected in order to complete reform process. Univerzitet u Nišu Ekonomski fakultet Krstić, Borko Živković, Aleksandar 1954- Marinković, Srđan 1970- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1345 https://fedorani.ni.ac.rs/fedora/get/o:881/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533524118 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1346 2015-10-16T00:00:00Z 2

Istraživanje turbulentnog dvofaznog strujanja u pravim kanalima pneumatskog transporta granularnog materijala nekružnog poprečnog preseka : doktorska disertacija RESEARCH OF TWO PHASE TURBULENT FLOW OF GRANULAR MATERIAL PNEUMATIC TRANSPORT IN STRAIGHT CHANNELS WITH NONCIRCULAR CROSS SECTION Milanović, Saša 1962- Pneumatski transport,čvrste čestice, kanal, dvofazna strujanja Pneumatic transport, Solid particles, Channel, Two-phase flow The two-phase turbulent flows of gas-solid particles, in the channels of noncircular cross-section (square, rectangular, etc.), are very often encountered in engineering practice. Examples of this flows type can be found in ventilation systems and air conditioning, in systems for pneumatic transport of granular materials, in turbo machines, heat exchangers, nuclear reactors, open channels, etc. Two-phase flows of gas-solids are characterized by a variety of phenomena which are a consequence of interaction the gas and the solid phases. In these channels beside the main stream along the channel occur secondary flows in the plane of the channel cross section. The mechanisms that lead to the secondary flows are different (curved channels, different temperature load of channel walls etc.). This type of flows, known as Prandtl’s secondary flow of the first kind, was the subject of a large number of researchers. A special flow phenomenon which occurs in straight channels in the regime of fully developed turbulent flow is a secondary flow of the second kind, known in the literature as secondary flow of Prandtl's second kind. To this problem is a very little attention has been paid so far in research practice. This flow has a significant impact in the total mechanism of mass, impulse and heat transfer in the channel and in environment. Transfers of high intensity impulses in the channel have as a consequence large gradients of transversal velocity in the plane of channel cross section. Produced secondary flow increase shear stress in the corners of the channels and has a significant effect on the intensity of heat transfer from fluid to the wall of the channel, and vice versa. These are some of the reasons why special attention to the phenomenon of secondary currents of the second kind in the two-phase system gas-solid particles is given in this paper. Considered flow is turbulent, steady, incompressible and fully developed in the straight channel of square cross-section, whose walls have a constant temperature different from the environmental temperature. Univerzitet u Nišu Mašinski fakultet Ilić, Gradimir Stevanović, Žarko Bogdanović, Božidar 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1346 https://fedorani.ni.ac.rs/fedora/get/o:882/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533579158 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1347 2015-10-16T00:00:00Z 2

Primena aditivnih tehnologija u izradi anatomski prilagođenih skafolda za rekonstrukciju koštanog tkiva : doktorska disertacija Application of Additive Technologies in Fabrication of Anatomical Custom Made Scaffolds for Bone Tissue Reconstruction Milovanović, Jelena 1974- Aditivne tehnologije, Koštano tkivo, Biomedicinski inženjering additive technologies – АТ, scaffolds, ASLS, ЕBM, DMLS, 3D Bioplotter Tissue engineering almost always involves the use of so-called scaffolds, which are expected to perform the role of an artificial (highly porous) extracellular matrix that is to provide a proper and sufficiently rapid cell growth and efficient reconstruction of tissue that has been damaged by injury or disease. In terms of structure, scaffolds are usually artificial lattice-like support structures of biocompatible materials which primarily provide the necessary mechanical support to the cells seeding in the process of tissue reconstruction. The second, equally important function that scaffolds should generate is to provide a smooth reinnervation and revascularization of new tissue and their communication (connection, ingrowth) related to the surrounding tissue. Bearing in mind the great importance of the scaffold in the process of (human bone) tissue reconstruction, the research into the development of an optimal design variant of a scaffold and technologies for scaffold manufacturing are crucial issues that have received much attention in tissue engineering (TE). Although a number of design concepts of scaffolds aimed at bone tissue reconstruction have been developed, there are still challenges to overcome in an effort to optimize the scaffold design. This implies satisfying different groups of requirements that can often be opposite. It is necessary to simultaneously achieve a high permeability of structure and a high level of bio-adhesiveness of the scaffold structure elements. Also, it is preferable for the scaffold to be biodegradable, and to provide the ability of adjusting the mechanical properties of a structure to specific load cases. Finally, scaffolds are expected to be geometrically consistent with patient-specific anatomical forms, while still being easy to fixate and implant, with a relatively simple technological process for their manufacturing. A particular challenge regarding scaffolds is related to finding an appropriate manufacturing process, which is the focus of the research in this dissertation. When it comes to the fabrication of scaffolds, they used to be fabricated by conventional methods for many years. However conventional methods showed several limitations such as the inability to precisely control pore size, pore geometry, pore interconnectivity, spatial distribution of pores and construction of internal channels within the scaffold. A significant problem of conventional manufacturing processes is also the presence of organic solvent residues due to their toxicity and carcinogenity . As an alternative to conventional scaffold fabrication methods, additive manufacturing technologies (AT) have emerged. AT enable the automatic construction of complex scaffold features, layer-by-layer, according to computer-aided design (CAD) data obtained from patient’s medical scans (CT). Advantages of using АТ processes in scaffold manufacturing include customization of the products to meet the individual needs (anatomical custom made scaffolds), ability to create complex geometries and high Примена адитивних технологија у изради анатомски прилагођених скафолда за рeкoнструкцију коштаног ткива 12 accuracy features, and possibility to control pore size and distribution of pores and the entire internal architecture of scaffold. New possibilities of scaffold manufacturing, brought on by AT, have encouraged the emergence of new approaches to the design of the internal architecture of these structures. In an attempt to reach a bone tissue scaffold that meets the TE requirements to the greatest possible extent, the team of the Laboratory for Intelligent Production Systems, engaged in the research on the project III41017, proposed the original concept of the scaffold design (structure) in the form of a solid and maximally permeable 3D latticed support structure - (Anti-Labyrinth) Anatomically Shaped Latticed Scaffold- ASLS, which consists of simple and interconnected struts. This design concept rejects the approach which tries to imitate the trabecular bone structure, the so-called labyrinthine concept. A detailed description of ASLS design concept is shown in the first part of the thesis. The success of the concept was verified by creating the models and manufacturing experimental samples of anatomical custom made scaffolds ASLS for the critical size defect (maximum size 10×8 mm) made on the proximal tibial diaphysis of experimental animals - rabbits. The geometric complexity of the ASLS design and the small size of the experimental samples required the application of AT. In this context, the main objective of this dissertation was to investigate the application of AT in the fabrication of anatomical custom made scaffolds for bone tissue reconstruction on the example of ASLS. After a detailed analysis, three AT were selected (3D bioplotter, DMLS and EBM) that were potentially capable of making such complex forms like ASLS. The first two were used to make permanent ASLS of Ti-alloys (Ti6Al4V and Ti64), while 3D bioploter was chosen as the only commercially available AT developed to plot biodegradable materials and biological cells, for making temporary (biodegradable) ASLS of hydroxyapatite (HA). For this purpose, ASLS samples were fabricated using the selected AT and a detailed analysis of the technological methods of making these samples by using the selected AT was conducted, and it showed the advantages and disadvantages of each of the AT used in the manufacturing of this class of bone scaffolds. These ASLS samples were also used in experiments that explored the features of the design concept ASLS from the point of implantation in vivo. In this pilot experiment, a defect was caused and ASLS was implanted in the tibia of a rabbit in order to examine the biological and mechanical properties ASLS which were characteristic for the bone scaffold. This opens new opportunities for further bio-medical research, which is expected to, in a positive scenario, lead to solutions for improving the recovery of bone tissue. Примена адитивних технологија у изради анатомски прилагођених скафолда за рeкoнструкцију коштаног ткива 13 An important result of the research is the definition of the criterial matrix for the assessment of AT applicability for bone tissue scaffold manufacturing and process applicability calculator. The results showed that EBM is currently the optimal choice for manufacturing of such metallic scaffolds. According to the mentioned comparative analysis of applicability, DMLS is just behind EBM and can support the development of complex forms ASLS, but with slightly lower performance. However, at this point of development, EBM and DMLS cannot be used to create temporary ASLS, i.e. from biodegradable materials. The indisputable advantage of 3D bioplotter, compared to other technologies, is the ability to plot biodegradable materials, and even cells. However, the main drawback of this technology is that it cannot be used (at the current moment of development) to make complex forms ASLS. Also, the criterial matrix for the assessment of AT applicability and process applicability calculator can be applied for comparative analyses of manufacturing processes for making similar shapes with the existing and future AT, changing the relevant parameters and their values defined for a particular case. Univerzitet u Nišu Mašinski fakultet Trajanović, Miroslav 1954- Mitković, Milorad Najman, Stevo Grujović, Nenad 1966- Manić, Miodrag 1957- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1347 https://fedorani.ni.ac.rs/fedora/get/o:883/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533579414 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1386 2015-10-16T00:00:00Z 2

Metode za rešavanje problema triangulacije poligona i njihova implementacija : doktorska disertacija Methods for solving the polygon triangulation problem and their implementation Saračević, Muzafer H. 1984- Računarska geometrija, objektno-orjentisano programiranje, objektno-orjentisano modeliranje, JAVA programiranje, UML modeliranje Triangulation of the convex polygon, JAVA programming, UML modeling The dissertation includes new methods in order to increase the speed of generating polygon triangulation. The first method is based on the process of decomposing the Catalan numbers. The second method is based on the construction of triangulation on the basis of blocks with emphasis on the possibility of storing and and working with databases in Java NetBeans environment. The dissertation will also study the above problem in terms of recording and storage in order to save storage space (the method of Alpha-numeric entry). The connection is given between notation triangulation with combinatorial problems (ballot and lattice path). The object-oriented analysis is also discussed as well as the design for the problem triangulation, with three aspects: forward, reverse and round-trip engineering. Univerzitet u Nišu Prirodno-matematički fakultet Stanimirović, Predrag 1959- Tasić, Milan 1972- Stevanović, Dragan 1974- Milošević, Danijela 1967- Krtolica, Predrag 1966- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1386 https://fedorani.ni.ac.rs/fedora/get/o:885/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024571113 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1395 2015-10-16T00:00:00Z 2

Analiza graničnog stanja upotrebljivosti pešačkih mostova u pogledu vibracija indukovanih pešacima : doktorska disertacija ANALYSIS OF SERVICEABILTY LIMIT STATE OF PEDESTRIAN BRIDGES REGARDING VIBRATIONS INDUCED BY PEDESTRIANS Spasojević-Šurdilović, Marija Pešački mostovi The advanced engineering technologies and the development of construction materials have brought the new trends in the design and construction of pedestrian bridges. Contemporary footbridges are slender and lightweight long span structures. As a consequence of the small mass and stiffness of the structure, reduction in the fundamental natural frequency of the bridge, results in greater sensitivity to dynamic loadings, especially the human-induced ones. Therefore, a more detailed dynamic analysis becomes necessary in the design of pedestrian bridges. For evaluation of the serviceability limit state of a footbridge, it is necessary that the superstructure response to human-induced vibration is known. As vibration analysis of bridges is very complex, the simplest solutions of vibration problem are the most acceptable to designers. For these reasons, using modal analysis, solutions such as a time depending response of the bridge superstructure were performed in the dissertation. Pedestrian-induced actions are modelled as deterministic forces, defined using the Fourier transform, and their position on the bridge is defined using the Dirac function, Heaviside function and Hermite polynomials. The response function is determined using the author’s algorithms and programs written in Mathematica. The dissertation presents three algorithms, which includes all girder structural systems. For dynamic analysis they are modeled as continuous or discrete oscillatory systems. Moreover, the superstructure of the bridge can be of a constant or a variable mass and flexural stiffness along the span. The response functions for the vertical and horizontal direction of vibration are defined using the same algorithms, with the introduction of the modal characteristics of the structure for the respective direction. The required response can present vertical displacement, horizontal displacement, velocity or acceleration, as well as stress and strain of the observed cross section, since the algorithms include such an option. The possibility option of response presentation trough time histories, significantly simplifies the qualitative and quantitative analysis. This is particularly important for the variation of the parameter, for example, intensity of the constant force, intensity of the amplitude and frequency of the time varying force, speed of the force, damping, and the position of the cross section of interest. The efficiency of the proposed dynamic analysis, carried out according to the above response functions, is shown for three pedestrian bridges of different structural systems and materials applied. The proposed analytical solutions to the vibration problem are easily applicable for various dynamic actions, so that they can represent a great help for designers to estimate the dynamic behavior of pedestrian bridges, which is a prerequisite for a contemporary and acceptable footbridge design principle and, with modern technologies, their quality construction. Univerzitet u Nišu Građevinsko-arhitektonski fakultet Dragoslav Stojić Stanko Brčić Branko Popović 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1395 https://fedorani.ni.ac.rs/fedora/get/o:887/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533614486 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1415 2015-10-16T00:00:00Z 2

Komparativna analiza parametara višeredne kompjuterizovane tomografije i patohistoloških nalaza kod karcinoma pluća : doktorska disertacija COMPARATIVE ANNALYSIS OF PARAMETERS FOR MULTISLICE COMPUTED TOMOGRAPHY AND HISTOPATHOLOGICAL FINDINGS IN LUNG CANCER Antuleska-Belčeska, Gordana V. Kompjuterizovana tomografija, karcinom pluća, pušački status, profesionalna eksponiranost, porodična istorija, TNM, senzitivnost, specifičnost MSCT, lung cancer, smoking status, occupational exposure, family history, TNM, sensitivity, specificity COMPARATIVE ANALYSIS OF PARAMETERS FOR MULTI-SLICE COMPUTED TOMOGRAPHY AND HISTOPATHOLOGICAL FINDINGS IN LUNG CANCER AIM: The main aim of this research is to demonstrate that the MSCT is a modality of choice, the ''gold standard'' for diagnosis and staging of lung cancer. Comparison of CT findings with histopathologically confirmed TNM stage confirmed also ability of this imaging modality in determination of morphological characteristics of certain histologic types of lung cancer. PATIENTS AND METHODS: This research represents a prospective - retrospective study of patients with lung cancer. A total of 173 patients with histologically confirmed NSCLC and SCLC were included. In the interest of the study, and to facilitate statistical analysis, all patients were divided into two groups: operable (117) and inoperable (56). We analyzed the CT morphological characteristics of lung cancer as well as demographic characteristics. RESULTS: Mean age of the participants was 60.2 ± 8.7 years. With regard to smoking status, the majority were smokers, the period of smoking was over 20 years, but in relation to duration and intensity of smoking patient were divided into three groups: smokers who smoked more than 20 years and more than a pack per day - 49.13%, smokers who smoked more then 20 years and a pack per day – 5.78% and group of smokers who smoked more than 20 years but intermittently - 15.61%. Occupational exposure is positive in 16.18% of patients, while a positive family history is present in 20.81% of patients. The most common type of cancer is adenocarcinoma 40.46%, followed by squamous cell carcinoma 34.68%. The sensitivity of MSCT imaging modality in T staging of lung cancer, taking pathohistological results as reference value, ranges from 72.73% to 99.8% and specificity ranges from 94% to 99.3%, while the global accuracy ranges from 97.43% to 98.29%. The sensitivity of MSCT in N staging of lung cancer ranges from 68.7% to 71%, the specificity was higher ranging from 92.3 to 94.1%, while the global accuracy ranges from 85.3% to 86.1%. CONCLUSION: In our study, we confirmed that MSCT is the ''gold standard'' in the 11 preoperative staging of patients with lung cancer. Multi detector computerized tomography provides detailed information not only on tumor size but also provides information on morphological characteristics of tumor. Univerzitet u Nišu Medicinski fakultet Petrović, Slađana 1961- Radovanović, Zoran 1970- Stojanov, Dragan Ristić, Lidija Stošić-Opinćal, Tatjana 1958- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1415 https://fedorani.ni.ac.rs/fedora/get/o:888/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024924909 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1416 2016-06-22T00:00:00Z 2

Klinički značaj intraamnijalne inflamacije kod prevremenih porođaja : doktorska disertacija THE CLINICAL SIGNIFICANCE OF INTRA-AMNIOTIC INFLAMMATION IN PRETERM BIRTHS Tasić, Marija S. 1965- Prevremeni porođaj, intraamnijalna inflamacija, zapaljenje, trudnoća, citokini, intrauterina infekcija, interleukin-6, fetalni inflamatorni odgovor pregnancy, inflammation, cytokines, preterm delivery, intrauterine infection, intra-amniotic inflammation, interleukin-6, fetal inflammatory response OBJECTIVE: The aim of this study was to determine the frequency, clinical characteristics and significance of intra-amniotic inflammation in patients with preterm labour. SUBJECTS AND METHODS: The study was conducted as a prospective, randomized study. The patients were divided into 2 groups. The examined group consisted of patients with singleton pregnancies and a diagnosis of preterm labor (PTL). The control group consisted of patients with singleton pregnancies delivered at term. Comparison of numerical and descriptive characteristics of the respondents was conducted between the experimental and control group, as well as among members of the examined group compared to the presence of abnormal colonization of the lower genital tract, the level of IL -6 in the amniotic fluid and placenta and fetal membranes pathological findings. Amniotic fluid samples were taken through a transabdominal amniocentesis, centrifuged, and were frozen at -70 ° C. The concentration of interleukin-6 was measured by a colorimetric high-sensitive ELISA test (R&D Systems) with a sensitivity of < 1pg/ml . Frequency of certain categories of descriptive characteristics between groups were compared by χ2 test or Fisher 's test. Comparison of numerical values of characteristics between the examined and control group was performed by Student's t-test or Mann-Whitney U test when not fulfilled the requirement of normality schedule. Comparison of numerical values between the three groups of subjects performed a one-sided analysis of variance (one- way ANOVA) and Tukey post-hoc test. Probability level of 5 % ( p < 0.05 ) is taken as the limit level of statistical significance. RESULTS: Pregnant women in whom preterm delivery had occurred, more frequently had burdened life history of desease and obstetric history. As well as the abnormal colonization of the lower genital tract is significantly more frequent finding in the examined group, it was also the presence of clinical chorioamnionitis, especially in cases with elevated amniotic fluid levels of IL-6. There is a frequent association of clinical and histological chorioamnionitis in the group of preterm labour. Preterm Premature Rupture of Membranes (PPROM) is significantly more frequent in the examined group as well as the elevated values of uterine artery RI. PPROM was significantly more often present in case of inflammatory changes in the placenta and fetal membranes (chorioamnionitis). IUGR and a high uterine artery RI are more often associated with pathological findings of placental vascular lesions. The majority of deliveries were completed vaginally in both groups, but the perinatal outcome (Ap score) was significantly worse in the group with PTL. AP score of 0-7 was more frequent in the group of preterm deliveries with elevated levels of amniotic fluid IL-6. As well as the onset of neuromorbidity, the overall neonatal morbidity was also more common in examined group. The histopathological findings with the presence of inflammation and vascular lesions were significantly more frequent in the experimental group, especially in cases of abnormal genital tract colonization. Perinatal mortality was significantly higher in the experimental group. Total perinatal mortality of the experimental group was significantly higher in the case of elevated levels of IL- 6 in the amniotic fluid. CONCLUSION: Preterm labor is a complex clinical syndrome, and intrauterine inflammation plays an important role in its etiopathogenesis. In cases of PTL, burdened life history is more frequent finding as well as the obstetric history of events that correlate with the process of inflammation (irregularity of menstrual cycles, infertility, previous miscarriages and premature births, bleeding in pregnancy, PIH and pre-eclampsia). Increased levels of IL-6 in the amniotic fluid are often accompanied with PTL and can be a sensitive biochemical marker of intrauterine inflammation and a good predictor of preterm delivery. Basically, fetal/neonatal inflammatory response syndrome can be considered as a crucial event in the high neuro and overall morbidity of preterm neonates. The high overall perinatal mortality in cases with elevated amniotic fluid IL-6 levels in preterm deliveries suggests an association of intra amniotic infection/inflammation and poor perinatal outcome. Univerzitet u Nišu Medicinski fakultet Kamenov, Borislav Popović, Jasmina Janošević Radović, Dragana Stefanović, Milan Vejnović, Tihomir 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1416 https://fedorani.ni.ac.rs/fedora/get/o:889/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024924141 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1420 2015-10-16T00:00:00Z 2

Dijagnostički i prognostički značaj serumskog amiloida A, prokalcitonina i D-dimera kod bolesnika sa vanbolnički stečenom pneumonijom : doktorska disertacija DIAGNOSTIC AND PROGNOSTIC ROLE OF SERUM AMILOID A, PROCALCITONIN AND D-DIMER IN PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA Nastasijević Borovac, Desa B. 1971- Vanbolničke pneumonije, prokalcitonin, serumski amiloid A, D-dimer, vanbolnički stečena pneumonija procalcitonin, serum amiloid A, D-dimer, community acquired pneumonia Severity assessment is a crucial component in the management of patients with community-acquired pneumonia (CAP). Recommended Pneumonia Severity Index (PSI) is an accurate predicting model, but not so easily applicable in clinical practice. The aim of the study was to determine whether some biomarkers of inflammation and coagulation, correlate with severity of CAP and can predict mortality risk better than standard biomarkers and recommended PSI. The study included 129 patients with CAP, an overall median age of 64.83 ± 13.32 y (77 males and 52 females). There were 55 (43.63%) patients with severe CAP. We were found a good linear correlation between severity of CAP and procalcitonin (r = 0.427; p < 0.001) and between D dimer (r = 0.5106; p < 0.0001). Serum amiloid A, WBC and CRP have poor linear correlation. In diagnosis of severe CAP best diagnostic value have procalcitonin (AUC = 0.813) and D-dimer (AUC = 0.789). Thirteen patients were died (10.7%), and 16 patients have complications (12.4%). In predicting of mortality risk PSI for cut of > PSI III showed sensitivity of 0.92, specificity 0.62 and AUC 0.868. Serum amiloid A, WBC and CRP were not in correlation with the risk of mortality. In non surviving patients D-dimer (2498.38 ng/mL) and procalcitonin (3.14 ng/mL) were significantly higher than in surviving patients. In predicting mortality risk, D-dimer (cut of >1538 ng/mL) showed sensitivity 0.84, specificity 0.86 and AUC 0.859. Procalcitonin, for cut of value > 0.93 ng/mL, in predicting of mortality risk showed sensitivity of 1.0, specifity of 0.64 and AUC 0.844. There was no statistical difference between AUC of PSI and D-dimer (p = 0.9005), and PSI and procalcitonin (p = 0.6135) in predicting mortality risk. This study pointed out that: serum amilod A correlates poor with severity of disease; and that high D-dimer and procalcitonin level correlate with severity of disease (better than CRP and WBC) and mortality risk (similar as recommended PSI). D-dimer and procalcitonin could be useful biomarkers for predicting severity of disease and clinical outcome in patients with CAP. Univerzitet u Nišu Medicinski fakultet Pejčić, Tatjana Stanković, Ivana Rančić, Milan Đorđević, Vidosava Lazić, Zorica 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1420 https://fedorani.ni.ac.rs/fedora/get/o:890/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024798445 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1421 2015-10-16T00:00:00Z 2

Utvrđivanje povezanosti hronične plak psorijaze i osnovnih kriterijuma metaboličkog sindroma : doktorska disertacija Determination of the relation between the chronic ”an plaque” psoriasis and the main criteria of the metabolic syndrome Damevska, Katerina S. 1964- Psorijaza, Metabolički sindrom, Komorbidna stanja, Komedikacija, Kardiovascularni rizik, Antipsorijatični lekovi Psoriasis, Metabolic syndrome, Comorbidity, Comedication, Cardiovascular risk factors, Antipsoriatics Psoriasis is a hereditary chronic skin disorder affecting 1–3 % of the general population worldwide. Presently, psoriasis is considered to be a Th1/Th17 involved inflammatory disease, characterized by chronically elevated pro-inflammatory cytokine levels. The metabolic syndrome (MetS) is a cluster of interrelated common clinical disorders, including insulin resistance, obesity, glucose intolerance, hypertension, and dyslipidemia. Other unexplored confounders, including genetic factors, diet, alcohol, physical activity, drugs and psychosocial factors, may contribute to several aspects of the metabolic syndrome. Previous studies have shown a possible association between psoriasis and the MetS. It has been hypothesized that this association may be explained by the state of chronic low-grade inflammation. There is little information available on the effects of drugs on the metabolic syndrome. Drugs used to treat psoriasis can adversely affect individual components of the MetS such as blood pressure and lipid concentrations. Thus, the objective of this study is to determine the prevalence of the metabolic syndrome, comorbidity and comedication in patients with psoriasis who have never received any systemic antipsoriatic drugs. The psoriatic patients were recruited from the University Clinic of Dermatology, at the Medical Faculty in Skopje between September 2011 and April 2012. The inclusion criteria for the patients were: age > 18 years and clinical diagnosis of plaque-type psoriasis lasting for at least six consecutive months. The study included only untreated patients. Thus, patients receiving systemic antipsoriatic drugs including acitretin, cyclosporine, methotrexate, psoralen-ultraviolet A therapy and biologics, were excluded. In addition, patients with other types of psoriasis (guttate, erythrodermic and pustular psoriasis), and patients with a history of autoimmune disorders were also excluded. Data collection included demographics, weight, height, waist circumference, BMI, blood pressure, smoking and drinking habits, age of psoriasis onset, type and severity of psoriasis, and presence of psoriatic arthropathy. Each control was matched to a case according to age (±1 year) and gender. The severity of psoriasis was assessed according to the Psoriasis Area and Severity Index (PASI) and the body surface area (BSA). The MetS was diagnosed by the presence of three or more of the criteria of the National Cholesterol Education Program’s (ATP III). Odds ratios (OR) were estimated by logistic regression models using the conditional likelihood and 95 % confidence intervals (CI) were computed. The proportion of the metabolic syndrome and its individual components for the patients was compared with their matched healthy controls. Comparisons were made using the Student’s t-test for parametric continuous variables, the Mann-Whitney U test for nonparametric continuous variables, and the Chi-square test for qualitative variables. The potential predictive factors of the MetS were identified with univariate and multivariate logistic regression. The significance was set at p ≤ 0.05 for all tests. One hundred and twenty-two patients with psoriasis (52 male and 70 female, mean age 51.52 years, SD 15.56, range 19–80 years), and 122 age- and gender-matched controls (mean age 51.98, range 19–79 years) participated in the study. No statistically significant difference was noted in age between the groups (p = 0.82). Type I psoriasis occurred in 78 patients (63.9 %). The mean duration of psoriasis was 17.9 years (range 1–65 years). PASI score ranged from 2.4 to 62.0 (mean 14.75), and 56 (45.9 %) had moderate to severe psoriasis. There was no significant difference in the prevalence of the MetS between the patients with psoriasis (24.6 %) and the controls (22.9 %) (OR 1.095, 95 % CI 0.607–1.974, p = 0.764). Among the individual components of the metabolic syndrome, hypertriglyceridemia and abdo-minal obesity were associated with psoriasis. The prevalence of hypertriglyceridemia in the patients with psoriasis and the controls was 41.8 % and 28.7 %, respectively (OR 1.78, 95 % CI 1.04–3.04, p = 0.032). The prevalence of abdominal obesity in the patients with psoriasis and the controls was 56.5 % and 35.2 %, respectively (OR 2.07, 95 % CI 1.24– 3.46, p = 0.005). There were no significant differences regarding the prevalence of hypertension, low HDL cholesterol and fasting plasma glucose between cases and controls. Smoking was significantly more often noted in psoriasis patients compared with controls (OR 1.813, 95 % CI 1.091–3.013, p = 0.021). The patients with psoriasis had a higher mean BMI (26.24, SD 4.42) compared with the controls (24.73, SD 3.86 ), p = 0.005. The patients were divided in two groups, according to the presence or absence of the MetS. The psoriatic patients with the MetS had a higher mean age (p = 0.001), and higher mean BMI (p = 0.001) compared with the patients without the MetS. The presence of the MetS was not associated with the severity of psoriasis (p = 0.674). Furthermore, there were no differences regarding gender, smoking and drinking habits, clinical characteristics of psoriasis, and presence of PsA. Univariate and multivariate logistic regression analyses were conducted to identify the variables predictive of the metabolic syndrome. The analyses identified age (OR 1.049, 95 % CI 1.014–1.085, p = 0.005), BMI (OR 1.268, 95 % CI 1.124–1.430, p < 0.001), and elevated triglycerides (OR 35.59, 95 % CI 12.593–100.6, p < 0.001), as significant predictors of the MetS. The growing body of evidence suggests a possible link between psoriasis and cardiovascular risks. Three elements contribute to the unfavorable cardiovascular risk profile in patients with psoriasis: systemic inflammation, systemic therapies and unhealthy lifestyle. Over the last decade, the association between psoriasis and the MetS has been well researched. A number of small case-control studies, large population-based studies, and meta-analysis, show a strong association between psoriasis and the metabolic syndrome. Several studies, however have not found such a relation. The prevalence of the metabolic syndrome among patients with psoriasis in other studies varies from 4.3 % to 53 %. There are conflicting study results regarding the prevalence of the individual components of the metabolic syndrome. In our study, there was no significant difference in the prevalence of the metabolic syndrome between the patients with psoriasis and the controls (24.6 % vs. 22.9 %, OR 1.095, p = 0.764). Similar to our observation, Mebazaa et al. (J Eur Acad Dermatol Venereol, 2011) detected higher prevalence of the metabolic syndrome in cases than in controls but without statistical differences (35.5 % vs. 30.8 %, p = 0.095). Kim et al. (Ann Dermatol, 2012) and Chen et al. (Arch Dermatol, 2008) findings revealed that the prevalence of the MetS among psoriasis patients was lower than among controls. In our study, among the individual components of the MetS, only hypertriglyceridemia and abdominal obesity were associated with psoriasis. These results are concurrent with some recent studies. Similarly to Gisondi et al. (Br J Dermatol, 2007) , and Kutlu et al.( Indian J Dermatol Venereol Leprol, 2011), we did not find correlation between the severity of psoriasis and the metabolic syndrome. In contrast, Sommer et al. (Arch Dermatol Res, 2006) reported an increased prevalence of the MetS in patients with psoriasis. It is noteworthy, that logistic regression analysis identified age, BMI, and hypertriglyceridemia as variables that favor the occurrence of the metabolic syndrome. There are several possible explanations for the diverse findings between our study and previous studies. Firstly, some studies were not completely matched for age and gender, which might influence the results. In addition, some studies are associated with high risk of selection and detection bias, due to the use of administrative databases. Furthermore, differences in nutritional habits and genetic susceptibility among different populations may affect the prevalence of the metabolic syndrome. Lastly, a selection of untreated patients with psoriasis eliminates the influence of systemic antipsoriatic drugs on the components of the metabolic syndrome. To our knowledge, this is the first case-control study to investigate the metabolic syndrome in untreated patients with psoriasis. Traditional systemic therapies for psoriasis may worsen CVR. Methotrexate increases homocysteine levels, cyclosporine and acitretin induce hyperlipidemia. Thus, the high prevalence of the metabolic syndrome in patients with psoriasis may be, in part, due to the systemic antipsoriatic drugs. Wakkee et al. argue that the effect of systemic drugs on the cardiovascular risk is a sum of anti-inflammatory effect and atherogenic side effect. It is difficult to assess the contribution of systemic antipsoriatic drugs on the development of the metabolic syndrome in patients with psoriasis. A number of concurrent factors, as inflammation and lifestyle factors, contribute to the metabolic syndrome. Furthermore, the influence of other systemic drugs such as NSAIDs (non-steroidal anti-inflammatory drugs), antidepressants and diuretics, needs to be taken into consideration, as these drugs are widely prescribed for patients with psoriasis. Nevertheless, our study confirms that the psoriasis patients compared with the controls, more frequently have three classic risk factors for cardiovascular disease: smoking, obesity and hypertriglyceridemia. Untreated patients with psoriasis have no significantly higher prevalence of the metabolic syndrome than healthy controls. Our data suggest that the systemic antipsoriatic drugs may play an important role in the pathogenesis of the metabolic syndrome. Future research of the impact of drugs on cardiovascular risk in psoriasis is needed. Univerzitet u Nišu Medicinski fakultet Binić, Ivana Pešić, Milica Jovanović, Marina 1955- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1421 https://fedorani.ni.ac.rs/fedora/get/o:891/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024761069 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1423 2015-10-16T00:00:00Z 2

Uticaj medikamentne terapije benigne hiperplazije prostate na seksualni život, funkciju i simptome donjeg urinarnog trakta : doktorska disertacija THE IMPACT OF MEDICAL TREATMENT OF BENIGN PROSTATIC HYPERPLASIA ON SEXUAL LIFE, FUNCTION AND LOWER URINARY TRACT SYMPTOMS Stojanović, Nebojša A. 1959- Prostata, seksualni život; tamsulosin; finasterid prostate; sexual life; tamsulosin; finasterid Introduction. Benign prostatic hyperplasia (BPH) causes disorders of voiding and sexual function. Pharmacologic therapy reduces symptoms of voiding thus impacting sexual function. Objective. Determining sex life status in men with BPH before and after pharmacologic treatment adapted to achieve satisfactory sexual function, and the impact this treatment on the function and lower urinary tract symptoms. Methods. 156 sexually active patients not previously treated for BPH were studied. After clinical examinations, symptoms of voiding, sexual and ejaculatory function were measured using standardized IPSS, IIEF and MSHQ-EjD questionnaires. After obtaining patients’ opinion about the importance of their sex life, the therapy was chosen and possible side effects explained. Four groups each of 39 respondents were formed. One group used alphablockers, tamsulosin, the second 5-alpha reductase inhibitor, finasteride, the third was administered combination therapy and the fourth control group without therapy. The complete examination procedure was repeated after 3 and 6 months of therapy. Results. The mean age of patients was 61.16  2.97. In the therapy groups 87% reported their sex life was important to some degree. Satisfaction with their sex life was reported by 47% of patients before treatment and 67% 6 months after treatment. Questionnaire indicated general improvement of sexual function (IIEF) in all groups statistically significant compared to baseline only in the group on alpha-blockers (2.95  7.81; p=0.028). Overall satisfaction with sex life compared to the beginning of treatment is significantly improved only in the group with combined therapy. Conclusion. Before treatment BHP, should be evaluated sexual function. Customize therapy to patient’s expectations. Present side effects of drugs, especially to those emphasizing the importance of sex life in order to improve it. Univerzitet u Nišu Medicinski fakultet Ignjatović, Ivan Đorđević, Nebojša Stojanović, Miroslav Bašić, Dragoslav Aleksić, Predrag 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1423 https://fedorani.ni.ac.rs/fedora/get/o:892/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024767213 sr Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)

oai:eteze.ni.ac.rs:1448 2015-10-21T00:00:00Z 2

Uticaj parametara pasivnog solarnog dizajna i aktivnih solarnih sistema na potrošnju energije u poslovnim zgradama : doktorska disertacija IMPACT OF THE PARAMETERS OF PASSIVE SOLAR DESIGN AND ACTIVE SOLAR SYSTEMS ON ENERGY USE IN OFFICE BUILDINGS Stevanović, Sanja Solarna energija, Pasivni solarni dizajn, energetska efikasnost, pasivni solarni dizajn Energy efficiency, passive solar design Recent recast of the EU Energy Performance of Buildings Directive, requesting all new buildings in the EU to consume `nearly zero' energy after 2020, requires the coherent application of passive and active design strategies in reducing heating, cooling and lighting loads and utilization of renewable energy. A necessary step in this process is application of the optimal combination of passive design measures, foremost among them being passive solar design measures, which aim to use the solar energy as much as possible in establishing thermal comfort in buildings, without the use of electrical or mechanical equipment. Although it is relatively simple to reduce the energy use up to some extent by applying individual measures, very high levels of energy performance require application of the optimal combination of several different measures. Building energy simulation plays a fundamental role in this process, since the energy use depends in a complex way not only on applied passive solar design strategies, but also on local climate factors. Purpose of this work is to study relationships between the parameters of passive solar design and the heating, cooling and lighting energy loads in office buildings, through a parametric study of a model of an office building located in Belgrade. The case study is a four-story office building, rectangular in shape, with longer sides facing south and north, with windows present at southern and northern facades only. The design parameters include six types of southern glazing types and of northern glazing types, seven values of windows-to-wall ratio for southern and for northern windows ranging from 25% (in order to satisfy minimal daylighting regulations) to 100%, presence of external shading at southern windows, as well as three U-values of external walls. In total, 10,584 building variants have been simulated in EnergyPlus. Analysis of simulation results leads to findings on the optimal windows-to-wall ratio and the optimal glazing choice for southern and northern facade, as well as on the influence of external shading on lowering cooling energy load. Additional simulations of a photovoltaic plant installation on the building model show that a significant number of building variants may became positive energy building with an integration of the photovoltaic plant in the roof of the building. Univerzitet u Nišu Građevinsko-arhitektonski fakultet Pucar, Mila 1946- Cekić, Nikola 1949- Bogdanović, Veliborka 1953- Krstić-Furundžić, Aleksandra Bojić, Milorad 1951- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1448 https://fedorani.ni.ac.rs/fedora/get/o:893/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533620118 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1449 2015-10-16T00:00:00Z 2

Epidemiološki aspekti lajmske bolesti na teritorije građa Beograda : doktorska disertacija Epidemiological aspects of Lyme disease on the teritory of Belgrade city Mladenović, Jovan Lj. 1973- Lajmska bolest,erythema migrans, krpelji, ixodes ricinus, Borrelia burgdorferi, entomološki indeks rizika, ekološki indeks Lyme disease, erythema migrans, ticks, Ixodes ricinus, Borrelia burgdorferi, entomological risk index, ecological index Aim: To evaluate risk from Lyme disease regarding way of removing ticks and time of ticks attachment on the skin. Evaluate clinical manifestations among patients with Lyme disease registered in Belgrade. Calculate values of ecologic and entomologic risk index in selected sites and existence of correlation with number of Lyme disease cases. Methods and subjects: The study covered a ten-year period from 2000 through 2009 year. The study included 5366 persons with the tick bite in the Institute of Epidemiology MMA and 1178 patients with Lyme disease registered on the territory of Belgrade. Epidemiological questionnaire was used to collect information about time and place of a tick bite, the method of removing the tick, the time spent in the skin, the remnants of the tick in the skin and the appearance of clinical manifestations of LB. On 5 sites in the territory of the five municipalities of Belgrade, selected on the basis of epidemiological ecological indications, 9648 ticks were collected and determined. Ticks were determined by the type by key of Pomerancev and developmental stage and gender according to the methodology of Furman and Katts. The presence of B. burgdorferi in ticks was determined by microscopy of native preparations in moist dark field microscopy by Kovalevsky's method. Entomological risk index is determined by the methodology Mather et al, and ecological index is determined by the methodology of Schulz et al. Results: Clinical manifestations of Lyme disease manifested in the form of EM were recorded in 29/5366 (0.5%) persons with a tick bite. The risk of developing Lyme disease was significantly higher in patients who had tick attached on skin from 48-72 hours (RR 28.67, 95% CI, 3.21 to 255.83, p = 0.001) and in patients with tick attached longer than 72 hours (RR, 37.64; 95% CI, 4.22 to 335.7, p = 0.0004). People who were removing ticks by themselves were at greater risk of developing LB (RR = 7.01, 95% CI, 3.11 to 15.79; χ2 = 30.01, p <0.0001) as well as those in whom the tick was not completely removed (RR = 10.78, 95% CI, 4.93 to 23.60, p <0.0001, Fisher's exact probability test). In patients with Lyme disease are the most common skin manifestations were 1098/1178 (93.21%), while the other clinical manifestations were present in much vii smaller numbers: neurological in 33/1178 (2.80%) cases, rheumatic in 29/1178 (2.46%) cases and cardiology in 13/1178 (1.10%). Entomological risk index showed a significant correlation with the number of patients observed by age (ρ = 0.628, p = 0.026) and months (ρ = 0.900, p <0.0001), but showed no significant correlation regarding the areas (ρ = 0.553, p = 0.167). Ecological index showed a significant correlation with the disease regarding areas (ρ = 0.918, p = 0.014). Conclusion: Based on the results of the study it can be concluded that an early and proper removal of ticks are an important measure for the prevention of Lyme disease. Entomological and ecological risk index can be a useful tool for assessing the risk of transmission of LB in certain areas indicating the necessity of taking appropriate preventive measures at both the individual level and at the level of the wider community. Univerzitet u Nišu Medicinski fakultet Tiodorović, Branislav Veličković, Zoran Čekanac, Radovan 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1449 https://fedorani.ni.ac.rs/fedora/get/o:894/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024799469 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1450 2015-10-16T00:00:00Z 2

Evaluacija uticaja terapije insulinskim analozima na parametre oksidativnog stresa kod bolesnika sa dijabetesom melitusom tip 1 : doktorska disertacija Evaluation of the effect of the therapy with insulin analogues on oxidative stress in patients with type 1 diabetes mellitus Radenković, Saša P. Dijabetes melitus tip 1, glikemijska kontrola, hipoglikemija, insulin aspart, insulin glargin, oksidativni stres, malondialdehid, nitrati i nitriti, ksantin oksidaza, antioksidantni enzimi diabetes mellitus type 1, glycemic control, hypoglycemia, insulin aspart, insulin glargine, oxidative stress, malondialdehyde, nitrite/nitrate, xanthine oxidase, antioxidant enzymes Significance of Type 1 diabetes mellitus is in it’s acute and chronic complications. Big studies demonstrated that microvascular complications of diabetes can be avoided or delayed if blood glucose levels are maintained as close to the normal range as possible. Diabetic state is closely related with increase in oxidative stress and studies suggest that ROS are important in pathogenesis of diabetic vascular dysfunction and that pathways of development of diabetic complications are closely connected with oxidative stress. High blood glucose leads to increase generation of ROS in mitochondria. Intensive insulin therapy is the cornerstone for tight glycemic control in type 1 diabetic patients. Basic difficulties in achieving glycemic goals are maintenance of near-euglycemia and avoidance of hypoglycemia and significant weight gain. Insulin analogues have improved pharmacokinetic properties that allow better control of both fasting and postprandial glycaemia. Aim of this work was to analyze efficacy of intensive insulin therapy with human insulin analogues (aspart and glargine) with analysis of glycoregulation (HbA1c, fasting blood glucose, postprandial glucose and glucose variability), safety with analysis of hypoglycemia, body weight and quality of life, and analysis of markers of oxidative stress. In this prospective clinical trial we analyzed clinical and laboratory parameters in Type 1 diabetic patients. Study included 49 patients with T1DM and previous therapy with human insulin for at least one year, currently on IIT with four daily doses of human insulin. For the first three months rapid acting insulin analogue (insulin aspart) was introduced instead of regular human insulin, and then in the next three months patients were treated with basal insulin analogue (insulin glargine) instead of intermediate acting human insulin. The mean HbA1c level fell after introduction of insulin analogues therapy. There was small but no significant decline in HbA1c level during 3 months of therapy with insulin aspart and HbA1c level continued to fall and after 3 month of therapy with combination of insulin analogues (aspart/glargine) was significantly lower than before initiation of therapy with analogues. There was significant decline in all postprandial glycaemia after three main vii meals during first 3 months of therapy. Blood glucose variability was significantly lower, as well as mean increment of blood glucose after the meals. At the end of the study all the values of blood glucose in glucose profiles were lower as well as mean blood glucose and glucose variability. Our results show significant reduction in the number of hypoglycemia after introduction of insulin analogues therapy. Number of all hypoglycemic episodes is lower after first three months of therapy and even more so after introduction of insulin glargine in the therapy. There were significant differences in the number of symptomatic, asymptomatic and night hypoglycemia. We recorded small, but significant weight loss and decline of the level of CRP. Our results show that in Type 1 diabetic patients level of oxidative stress (measured as MDA) is significantly higher than in control population. There was also significantly higher level of nitrates and nitrites in patients compared with control subjects, higher activity of XO, there was significantly lower activity of SOD and significantly higher activity of catalase and GPx. Level of MDA is significantly lower after therapy, as was the level of nitrates and nitrites and XO, there was a significant rise in activity of SOD and significant fall of activity of catalase and GPx. Intensive insulin therapy of Type 1 diabetic patients with insulin analogues (aspart and glargine) leads to better glycemic control with smaller number of hypoglycemic episodes and small weight loss. Intensive insulin therapy of Type 1 diabetic patients with insulin analogues (aspart and glargine) through improvement of glycemic control improves parameters of oxidative stress. Univerzitet u Nišu Medicinski fakultet Kocić, Radivoj 1958- Ilić, Stevan 1949- Pešić, Milica Stojanović, Ivana 1962- Lalić, Nebojša M. 1958- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1450 https://fedorani.ni.ac.rs/fedora/get/o:895/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024842733 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1451 2015-10-16T00:00:00Z 2

Kvalitet života i funkcionalni oporavak bolesnika nakon rehabilitacije posle prvog moždanog udara : doktorska disertacija THE QUALITY OF LIFE AND FUNCTIONAL RECOVERY AFTER A FIRST-STROKE REHABILITATION Mandić, Milan N. 1969- Fizikalna terapija, akutni moždani udar, kvalitet života, rehabilitacija Acute brain stroke (ABS), quality of life (QOL), rehabilitation Scientific field: Clinical Medicine Introduction. Brain stroke is considered to be the third main cause of death in developed countries, the first two being cardiovascular diseases and cancer, and the second one regarding worldwide population. Objective. The aim of the research was to compare the quality of life of the patients who were treated in hospitals having a longer period of rehabilitation in spa conditions with the quality of life of the patients who did not have any rehabilitation treatment in hospitals. Methods. The method that was used is a prospective cohort study. It included 196 patients at the age of 30 to 79, all of them being the citizens of Nis district. Te cohort consisted of the patients who had had an acute brain stroke for the first time in their lives (ABS) during 2011, 2012, and 2013. The beginning of the study was defined by the date of the first ABS. The study lasted from the 1st of April 2011. until the 15th of August 2013. The control group consisted of 60 patients who did not have any rehabilitation treatment in hospital after the first ABS. The functional recovery of patients was followed by use of Barthel index (BI) and of the Modified Rankin scale (RS).The questionnaires which were used:The general questionnaire used for estimating the quality of life was the Short form SF 36 (SF-36), the specific questionnaire for examining the functional status of neurological patients who survived brain stroke were the Stroke Impact Scale (SIS), “Mini-mental state examination” (MMSE), the level of neurological damage was measured by NHSS, EQ VAS and EQ5D. The questionnaires were used four times: at the admission, 1, 3, and 6 months after the stroke. Multivariant linear regression analysis was applied. Results. ABS leads to a significant destruction and decrease of HRQOL in all of its domains. Since physical functions of patients were the weakest immediately after the acute brain stroke, and their disability was greatest at the admission , they evaluated their own health condition and their quality of life as being lowest at the admission and within the first month. At the end of the research the quality of life was significantly higher with the patients who had rehabilitation treatment in hospitals. Conclusion. The quality of life of patients after ABS is significantly damaged and lower both in the early phase of recovery and 6 months after the stroke. Six months later the patients from the experimental group had a significantly higher quality of life in comparison with those from the control one. Univerzitet u Nišu Medicinski fakultet Aranđelović, Mirjana Živković, Miroslava 1955- Bošković, Ksenija 1962- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1451 https://fedorani.ni.ac.rs/fedora/get/o:896/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024931821 sr Autorstvo 3.0 Srbija (CC BY 3.0)

oai:eteze.ni.ac.rs:1452 2015-10-16T00:00:00Z 2

Institucionalne promene u funkciji unapređenja efikasnosti privrede : doktorska disertacija INSTITUTIONAL CHANGES IN FUNCTION OF IMPROVING EFFICIENCY OF THE ECONOMY Gligorijević, Nemanja J. Institucionalna ekonomija, institucije, ekonomske performanse, komparativna institucionalna analiza institutions, institutional change, economic performance, good governance, institutional inefficiency, New institutional economics, comparative institutional analysis Summary: Establishing of the New institutional economics as dominant institutional theoretical perspective, has contributed to the theoretical affirmation of the institution and to the recognition that institutions and institutional changes are an important part of the overall dynamics of economic reality. Therefore, the importance of defining the “new” institutional paradigm is reflected not only in the "endogenization" of the institutions as the relevant economic variables, but also in the possibilities of a broader consideration of the potential contribution of institutions to the overall macroeconomic performances. However, despite to the significant theoretical achievements in the economic recognition of the multiple institutional importances, in the observation of institutional change as a determinant of economic development, many questions remain open. For instance, it is still not known which institutions, in which specific forms required, or rather useful for economic development, or in which context. Although it is known the role that specific institutions can play in the process of the economic development, the problem is how to build such institutions. If developmental effects generally depend on the quantity and quality of institutional changes, than how to explain the fact that the establishment of the same institutional forms in the countries with approximate developmental preconditions, usually in practice does not led to the equal developmental results? This study, in form of a doctoral dissertation, is exactly driven by such issues. Therefore, as its primary goal assumes the theoretical development of the concept of institutional contributions to the development and identification of institutional criteria and mechanisms for improving economic performance. The basic assumption on which this dissertation is based implies that institutions and institutional changes are necessary, but not sufficient condition for good macroeconomic performance of the country. This additional requirement is contained precisely in the implementation of „good governance“, namely the establishment of the basic principles of this concept. The research is based on an analytical basis of the theoretical framework of the New institutional economics. Starting of the known information about the nature of institutions and institutional change, as well as on the basic assumptions of institutional sustainability and efficiency, there are theoretical elaborated concept of the institutional contributions to the development. Special attention was given to comparative institutional analysis. By combining information from different comparative economics, there are studied the relationship between institutional quality and economic efficiency. An attempt was made in order to identify main channels through which institutional quality determined economic performance, and therefore which is a possible causes of institutional inefficiency. Through the analysis of several representative cases in practice, the empirical validity of the findings is further checked. Since development issues become topical, especially during the crisis, it is clear incentives to explore the institutions and mechanisms of institutional change and use this knowledge in achieving, in a greater degree, controlled development. Univerzitet u Nišu Ekonomski fakultet Petrović, Dragan Leković, Vlastimir 1955- Stefanović, Zoran 1948- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1452 https://fedorani.ni.ac.rs/fedora/get/o:897/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533620374 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1454 2015-10-16T00:00:00Z 2

Uticaj različitih tehnika ekstrakcije i destilacije na hemijski sastav etarskog ulja i ekstrakta iz biljnih vresta roda Thymus L. : doktorska disertacija EFFECT OF DIFFERENT TECHNIQUES OF EXTRACTION AND DISTILLATION ON CHEMICAL COMPOSITION OF ESSENTIAL OIL AND EXTRACTS FROM SPECIES OF THE GENUS THYMUS L. Petrović, Slobodan S. Etarska ulja, antimikrobna aktivnost, Etarska ulja, nadkritična ekstrakcija, antioksidativna aktivnost Thymus serpyllum L., Thymus vulgaris L., hydrodistillation, supercritical extraction, essential oil, chemical composition, antioxidant activity, antimicrobial activity, extraction kinetics, mathematical modeling The objective of this dissertation is to obtain essential oils and extracts from plants of the genus Thymus L. primarily from wild thyme by different techniques of distillation and extraction, mathematical modeling of the process of supercritical carbon dioxide extraction and investigation of chemical composition, antioxidant and antimicrobial effects of obtained extracts and essential oils . For the isolation of essential oils and extracts it will be used hydrodistillation of essential oil by water and steam in the original device SP -130, hydrodistillation of essential oils in Clevenger apparatus according to the procedure prescribed by the Ph. Jug. IV and Euro Ph. 6.0, supercritical extraction with carbon dioxide and the Soxhlet extraction using 70 % of ethanol and n - hexane. Mathematical modeling of the kinetics of supercritical carbon dioxide extraction at different conditions of pressure and temperature, will be tested on the example of two plant species of the genus Thymus sp. (Thymus serpyllum and Thymus vulgaris) using mathematical models based on differential mass balance. Since there is no data in the literature about application, kinetics and conditions of supercritical extraction for obtaining extracts from wild thyme chemical composition, antioxidant and antimicrobial activity has been determined only for this plant species. The results showed that the essential oil of wild thyme obtained in the SP -130 and the essential oil obtained in Clevenger apparatus have the highest content of sesquiterpene components, while their content in extracts obtained by extraction by Soxhlet and supercritical fluid extraction was much lower. Gas chromatographic analysis of some the most common components in the essential oil of wild thyme: trans- nerolidol, germacrene D, thymol, δ-cadinene and -bisabolene. Results of the chemical composition of supercritical extracts differ significantly from the literature in qualitative and quantitative terms. Among all of investigated extracts and essential oils, supercritical extract FR1 contained most monoterpenes (30.36%), primarily from the group oxidized monoterpenes (30.24 %), with thymol as the dominant component (29.36%). The essential oil of wild thyme showed significant antioxidant activity, more potent than BHT and BHA, and can be used as an antioxidant component in the form of a nutritional supplements for the prevention or slowing down of the oxidative stress caused by free radicals, or as potential natural antioxidants in the food industry instead synthetic antioxidants, BHT and BHA. It was shown that in DPPH radical assay the order from the strongest to the weakest antioxidant activity of essential oils and extracts of wild thyme was: essential oil obtained in the SP-130, essential oil obtained in the apparatus by Clevenger, BHA, ethanol extract, ethanol extract/pretreatment with n -hexane, BHT, supercritical extract 30 MPa, n-hexane extract, supercritical extract FR1 and the supercritical extract FR2. The essential oil and extracts of wild thyme exhibit a pronounced antibacterial and antifungal activity on all of the tested bacterial strains, the Gram (+) and Gram (-), and fungi in comparison to commercial antibiotics, ampicillin and streptomycin and commercial fungicides bifonazole, ketoconazole used as controls. Also, antibacterial and antifungal activity of essential oils and extracts of wild thyme is comparable with thymol ( 99% purity). Supercritical extracts of wild thyme exhibited a significant antimicrobial activity against all tested bacteria (MIC 0.038-0.2 mg/ml, MBC 0.075-0.3 mg/ml). Inhibition values for ethanolic extract ranged MIC 0.038 - 0.2 mg/ml, MBC 0.15-0.3 mg0/ml. Inhibition values for ethanol extract/pretreatment with n-hexane ranges MIC 0.075-0.15 mg/ml, MBC 0.15-0.3 mg/ml. Also, the essential oil exhibited a significant antimicrobial activity against all tested bacteria (MIC 0.019-0.15 mg/ml, MBC 0.039-0.3 mg/ml). Reference antibiotics: Streptomycin (MIC 0.05-0.3 mg/ml, MBC 0.1-0.5 mg/ml) and Ampicillin (MIC 0.3-0.8 mg/ml, MBC 0.5 -1.25 mg/ml), and standard thymol (MIC 0.025 - 0.1 mg/ml, MBC 0.05-0.1 mg/ml). Supercritical extracts exhibited a significant antifungal activity against all tested fungi, (MIC 0.017 to 0.15 mg/ml, MBC 0.075 to 0.3 mg/ml). Ethanol extract exhibited antifungal activity in the range MIC 0.075-0.15 mg/ml, MBC 0.15-0.3 mg/ml). Ethanol extract/pretreatment with n-hexane is (MIC 0.075 to 0.3 mg/ml, MBC 0.15 to 0.7 mg/ml). The essential oil has affected all tested fungi inhibitory in the range MIC 0.0195 - 0.039 mg/ml and MBC 0.039 to 0.078 mg/ml. Reference antifungals Ketoconazole (MIC 0,2-2,5 mg/ml, MBC 0.5-3 mg/ml), and Bifonazole (MIC 0.1-0.2 mg/ml, MBC 0.2-0.3 mg/ml), and standard thymol (MIC 0.01 - 0.025 mg/ml, MBC 0.01-0.5 mg/ml) Univerzitet u Nišu Tehnološki fakultet Lazić, Miodrag 1955- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1454 https://fedorani.ni.ac.rs/fedora/get/o:898/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/45097231 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1482 2015-10-16T00:00:00Z 2

Prevalencija i faktori rizika za nastanak poremećaja govora kod učenika prvog razreda osnovnih škola Nišavskog okruga : doktorska disertacija THE PREVALENCE AND RISK FACTORS FOR THE DEVELOPMENT OF SPEECH DISORDERS PUPILS IN THE FIRST CLASS ELEMENTARY SCHOOL CITY OF NIS AND THE SURROUNDING Ristić, Snežana J. Poremećaj govora, deca prvog razreda osnovnih kola, prevalencija, faktori rizika speech disorders, children of the first grade, prevalence, risk factors Introduction explains in detail the stages of development of speech and generally accepted classification of speech disorders. The author presents the results of epidemiological studies, as well as the risk factors of previous research in the field of speech and voice disorders. The aim of this study was to determine the prevalence and risk factors for speech disorders in first grade pupils of elementary schools city of Nis and its surrounding. Materials and method. The research is sectional study and included 1030 pupils (aged 7 years) of elementary schools city of Nis and its surrounding (generations 2012 and 2013). The survey used: questionnaires for parents, parent and teacher interviews, examination of children with disorders of speech, hearing test in children with disorders of speech, global articulation test, a test of auditory perception and test of oral praxis. Results of the research presented in the order of implementation, a number of relevant tables and graphs and fully derived from applied research methodology. Pathological conditions were recorded with 202 pupils (19. 6%). It was found that the most common speech disorder in children dyslalia which included children with irregular saying to ten votes. The discussion was posted on the issues raised in the objectives of the dissertation. Conclusion provides a solution set of scientific goals and encourages further investigation of the prevalence and risk factors for disorders of speech, for preventive action and timely implementation habilitacionih treatment, with the purpose of being improving the quality of life of children with these disorders and facilitate their involvement in the educational and social environment. Scientific contributions. This cross sectional study in the field of public health is an original and independent scientific work of the author. Epidemiological studies has not been conducted in Southeast Serbia. Application of modern literature, research methods and scientifically valid statistical data processing obtained results are applicable to clinical practice. Knowing that there are in the first grade of elementary schools represented pathological conditions allow authors recommend for early assessment of speech disorders in children, because the overall success and future of a child can be significantly improved by early identification of communication disorders, their causes, detection and timely and appropriate intervention. Results can be used for scientific purposes, and for the implementation of the National Programme and organization of professional teams for the control and treatment of these disturbances. They can also be used to promote prevention, as well as education of parents to participate fully in the health care of their children. Univerzitet u Nišu Medicinski fakultet Kocić, Biljana Petrović, Branislav 1953- Živić, Miško Stanković, Milan Dimitrijević, Bojana 1961- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1482 https://fedorani.ni.ac.rs/fedora/get/o:900/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024956653 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1483 2015-10-16T00:00:00Z 2

Zastupljenost mutacija i R202Q polimorfizma gena za porodičnu mediteransku groznicu i njihov uticaj na oksidativni stres i kliničke zapaljenske manifestacije : doktorska disertacija DISTRIBUTION OF MUTATIONS AND R202Q POLYMORPHISM OF THE GENE FOR FAMILIAL MEDITERRANEAN FEVER AND THEIR INFLUENCE ON OXIDATIVE STRESS AND CLINICAL MANIFESTATIONS OF INFLAMMATION Radović, Jelena M. 1982 Mediteranska groznica, MEFV gen, mutacija MEFV gena, mutacija MEFV gena, R202Q polimorfizam, febrilnost, oksidativni stres, autoinflamacija MEFV gene mutations, R202Q polymorphism, autoinflammation, febrile episodes, oxidative stress Introduction The Mediterranean fever gene (MEFV) has special importance in autoinflammatory diseases (AID) etiology. The MEFV gene codes for protein pyrin, one of the inflammasome regulators in the innate immune cells. Mutations and R202Q polymorphism of the MEFV gene alter pyrin function, consequently leading to a dysregulation of interleukin-1β release, activation of NF-κB, apoptosis, as well leukocytes oxidative burst. Mutations M680I, M694V, M694I, V726A and E148Q represent the largest percentage of all mutations. Although the R202Q polymorphism in heterozygous form is a benign alteration, several studies confirmed that R202Q homozygotes may develop AID. Familial Mediterranean fever is the most common hereditary autoinflammatory disease with MEFV gene mutations. However, these mutations are determined in a number of other diseases, where they predispose a proinflammatory state, such as: Behcet's disease, Henoch-Schonlein purpura, ulcerative colitis, systemic lupus erythematosus, multiple sclerosis, etc. The acute phase of AID is caracterised by increased body temperature, abdominal pain, arthralgia, myalgia, erysipeloid rash, fatigue, etc. There is an inflammatory reaction in the blood and increased oxidative stress, detected through the decreased antioxidant activity and increased levels of oxidatively modified molecular products. However, various clinical presentation in the presence of the same MEFV mutations in different individuals, as well as disease in heterozygotes, led to a reconsideration of the role and significance of MEFV gene changes. It is found that mutation carriers have a tendency for febrile episodes, frequent occurrence of rheumatic diseases, and increased levels of acute phase reactants. It is assumed that still unknown modifying genes or environmental factors are partially responsible for AID in heterozygotes. Aim The aim of this study was to investigate the presence and distribution of the MEFV gene mutations and R202Q polymorphism in healthy population in Serbia. Also, the intention was to determine the incidence of recurrent fevers and other clinical signs of inflammation in persons with mutations and R202Q polymorphism, and compare with persons without these changes. In addition, it was investigated whether persons with MEFV changes have altered oxidative stress parameters and what is their association with inflammatory events. Methods The study enrolled 100 healthy subjects. The investigation protocol included: collection of health data (using the official Eurofever project questionnaire) and collection of blood samples to perform genetic test and analysis of oxidative stress parameters. DNA was extracted from peripheral blood leukocytes. DNA sequencing was performed using ABI PRISM 310 automated sequencer (Applied Biosystems, USA). Thiobarbituric acid reactive substances test (TBARS) in plasma was performed by the spectrophotometric method of Andreeva et al. TBARS in erythrocytes were determined by spectrophotometric method of Jain et al. Advanced oxidation protein products (AOPP) were determined spectrophotometricaly and calibrated by chloramine-T solution by the method of Witko-Sarsat V et al. Determination of superoxide dismutase (SOD) was performed with pyrogallol method (McCord J, Fridovich I). Catalase activity was determined by catalase ELISA kit (Enzo Life Sciences), following the manufacturer's instructions. Results Out of 100 examined subjects 11% had MEFV gene mutation: 6% heterozygous E148Q/N mutation and 5% K695R/N. There were 10% of R202Q polymorphism homozygotes and 45% heterozygotes. Unexpectedly, the carrier frequency of mutations and R202Q polymorphism was relatively high for a healthy population in Serbia. Regarding clinical manifestations, persons with the mutations and R202Q homozygotes reported more frequently: febrile episodes of unknown cause (p=0.027), diffuse abdominal pain (p=0.015), peritonitis (p=0.019) and fatigue (p=0.012) in comparison with persons without these gene changes. Individuals with the MEFV gene mutations had more frequently recurrent febrile episodes (p=0.048), diffuse abdominal pain (p=0.017), peritonitis (p=0.008) and fatigue (p=0.032). R202Q homozygotes have experienced significantly more often repeated episodes of fever (p=0.022), diffuse abdominal pain (p=0.009) and lymphadenopathy (p=0.035). Recurrent fever and nonspecific abdominal pain are the most common symptoms in most AID with MEFV gene mutations and suggest the existence of a modified immune response in these persons. Individuals with the MEFV mutations and R202Q homozygotes had significantly higher concentration of erythrocytes TBARS compared with persons without these gene changes (p=0.03), suggesting the existence of increased oxidative damage of erythrocyte membranes. Also, the plasma SOD activity was significantly higher in these individuals (p=0.049), and in R202Q homozygotes particular (p=0.001), which may be due to increased induction of extracellular SOD. Changes in oxidative stress parameters in the MEFV changes carriers were significantly associated with biochemical parameters of inflammation (leukocytes count with erythrocyte TBARS (p=0.009) and erythrocyte sedimentation rate and SOD levels (p=0.031)). Conclusion The MEFV gene mutations are present in 11% of healthy persons in Serbia, those are E148Q/N in 6% and K695R/N in 5% of people. There are 10% homozygote for R202Q polymorphism and 45% heterozygote R202Q carriers in Serbian population. Persons with E148Q and K695R heterozygous MEFV gene mutations and R202Q homozygous polymorphism have frequently febrile episodes of unknown cause, as well as other non-specific manifestations of inflammation. The mutations carriers and R202Q homozygotes have significantly higher values of erythrocyte TBARS and plasma SOD activity, compared with persons without aforementioned genetic changes. Frequent occurrence of non-specific inflammation manifestations in mutation carriers and R202Q homozygotes indicates that these MEFV gene changes are a predisposition for development of inflammation. Changes in oxidative stress parameters indicate the existence of a mild oxidative stress and stimulation of the innate immune response together with possible changes in specific leukocyte functions in these individuals. Univerzitet u Nišu Medicinski fakultet Vojinović, Jelena 1965- Bojanić, Vladmila Milojković, Maja 1967- Jevtović-Stoimenov, Tatjana Mitrović, Tatjana 1969- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1483 https://fedorani.ni.ac.rs/fedora/get/o:901/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024948205 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1484 2015-10-16T00:00:00Z 2

Uticaj primenjene hirurške tehnike i vrste šavnog materijala na nastanak dehiscencije laparatomije : doktorska disertacija The influence of surgical techniques and types of suture materials on the occurrence of dehiscentio after laparotomy Paunović, Milorad Laparatomija Dehiscentio after laparotomy is a postoperative complication that occurs in up to 3% of patients. The choice of surgical materials, surgical techniques of sewing, and a choice of incision and assessment of tension on the wound edges are variables that depend on the subjective choice of surgeon, based on his experience (years of surgical experience), knowledge and ability. The study will include 826 patients for general and vascular surgery clinic in Nis. The tested patients was divided in two groups: experimental (a group of patients in whom there was a complication- dehiscentio after laparotomy) and the control group (patients in whom dehiscentio after laparotomy did not occur). Surgeons who operate patients with dehiscence laparotomy were significantly younger (they had surgical experience smaller from 20 years) than surgeons who operate patients without dehiscence laparotomy (they had surgical experience longer from 20 years). There is a statistically highly significant correlation between laparotomy dehiscence and continuous closure. There was a statistically significant association between dehiscence laparotomy and nylon like a suture materials. Patients with greater number of risk factors are predisposed for development of postoperative wound complications, therefore it is important to identify them early and treat those patients with care. Good preoperative preparation reduce postoperative wound complications. Univerzitet u Nišu Medicinski fakultet Jovanović, Milan Višnjić, Milan Radojković, Milan Stevanović, Goran Paunović, Iva. 1955- 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1484 https://fedorani.ni.ac.rs/fedora/get/o:902/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024702957 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1485 2015-10-16T00:00:00Z 2

Uticaj endometrioze na ishod vantelesne oplodnje : doktorska disertacija IMPACT OF ENDOMETRIOSIS ON IN VITRO FERTILIZATION OUTCOME Pop-Trajković-Dinić, Sonja Z. Materica, endometrioza, infertilitet, vantelesna oplodnja, laparoskopija endometriosis, infertility, in vitro fertilization, laparoscopic surgery Endometriosis is a frequent gynecological disease most often diagnosed in women during the reproductive years. It has been estimated that endometriosis occurs in roughly 10–15% of general population,and in women with infertility up to 40%. Endometriosis is one of the biggest challenges for gynecologists who deal with the problem of infertility. Mechanism of infertility occurence due to endometriosis is still unknown. Many factors can demonstrate the connection between infertility and endometriosis. Using the method of in-vitro fertilization (IVF), it is possible to influence some of these factors in order to improve reproductive function. However, what still is the issue of in-vitro fertilization program is a response to ovarian stimulation of patients with endometriosis. A number of controversial conclusions can be made when going through the literature on this topic. In the modern treatment of endometriosis, laparoscopic surgery is the first line treatment and is considered the "gold standard" method of treating female infertility. The fact is that a large number of younger patients (40-50%) conceive in the first two years after a laparoscopic procedure done correctly by an experienced gynecologist. So there is still more than 50% of patients to become candidates for in-vitro fertilization, as a complementary, rather than competing method of treating marital infertility. Endometriosis in IVF treatment is a serious problem, both for gynecologists in order to obtain a greater number of egg cells, and for embryologists in order to obtain a greater number of high-quality embryos. Modern literature is facing a problem of reduced ovarian response in women operated on for endometriosis, especially in those where there is a recurrence. There is a divergence in the opinion of the authors, and various studies attempt to point out the best route. Literature reports different approaches to patients with endometriosis who enter the IVF program, in relation to age, size of the endometrioma, endometriosis stages and approach to recurrence of endometriosis. The data are controversial, and so far there are no major randomized trials that clearly indicate the impact of endometriosis on the outcome of the IVF and which would form protocols approach to patients with endometriosis who concieve through IVF program. Therefore, the aim of our study was: 1. To examine ovarian reserve in patients operated on for endometriosis, prior to entering the IVF program. 2. Assessment of ovarian response to stimulation in the IVF procedure in patients operated on for endometriosis. 3. Evaluation of IVF outcome (rates of clinical pregnancy, abortion and childbirth) in patients operated on for endometriosis. 4. The impact of (I-IV) endometriosis stage on the IVF course and outcome. 5. The impact of endometriosis recurrence on ovarian reserve, ovarian response, as well as on the course and outcome of the IVF. 6. Examine what gives higher success rate of IVF: a re-operation of endometriosis before entering the IVF program or entering into the IVF program with recurrence of endometriosis. 7. Establishment of protocols for assessment of the patients with endometriosis who are in the process of IVF. The study was conducted as a prospective-retrospective study at the Department of Gynecology and Obstetrics, Clinical Center Nish, and the Institute of Human Reproduction, Department of Gynecology and Obstetrics, Clinical Center Vojvodina, in the period from 2009. to 2012. Prospective part of the study included monitoring of the patients in the process of in-vitro fertilization (IVF), and the retrospective section applies to diagnostic procedures and surgeries before entering patients in IVF process. The study included 235 patients who had undergone the IVF program. The study group included 78 patients with endometriosis as a cause of marital infertility, and the control group of 157 patients with tubal cause of marital infertility. Certain patients underwent more than one cycle at the same clinic. For other patients, the data of previous IVF attempts, were obtained from the discharge lists from other IVF centers. After satisfying the criteria for inclusion and exclusion from the study, in all patients was observed 21defined parameter in the IVF procedure: Basal FSH, patient age, body mass index, smoking, previous pregnancy, length of infertility in age, stimulation protocol, number of ampoules used for stimulation, length of stimulation, number of follicles larger than 15 mm, number of aspirated egg cells, number of obtained embryos, number of transferred embryos, overall pregnancy rate per embryo transfer (ET), biochemical pregnancy rate per embryo transfer, clinical pregnancy rate per embryo transfer, the rate of abortion, multiple pregnancy rate, birth rate per ET, the rate of interrupted IVF cycle and the rate of hyperstimulation. All the parameters in the study group were monitored and compared to the stage and recurrence of endometriosis. In relation to the stage, patients were divided into two subgroups – I group included patients with I and II stage of endometriosis, II group included patients with III and IV stage of endometriosis. All these parameters used in research were compared between the two groups and compared with the control group. In relation to recurrence of endometriosis, the examined group of patients was divided into three subgroups: the first group consisted of patients who had undergone one surgical procedure and showed no signs of endometriosis at the moment of involvement in IVF process; the second group consisted of patients who had undergone one surgical procedure but had recurrence of endometriosis at the moment of involvement in IVF process, and the third group consisted of patients who had undergone two or more surgical procedures and showed no signs of endometriosis at the moment of involvement in IVF process. All parameters were compared among the groups and with the control group. After the results had been examined and compared to current literature data and past studies in the field, the following conclusions were made:  Presence of endometriosis in the IVF procedure does not affect the quality of embryo, or the rate of fertilization, implantation, clinical pregnancies and labors. However, presence of endometriosis affects the number of oocytes, so these patients need more ampoules of gonadotropins in the process of stimulation, which increases the cost of treatment to achieve pregnancy. The benefit of IVF procedure for patients with endometriosis lies partly in controlled ovarian hyperstimulation and achieving greater number of oocytes, which enables better choice of quality oocytes and thus a better fertilization. Likewise, the choice of sufficient number of quality embryos for transfer compensates for the disrupted implantation. The results add to benefit of using GnRH analogues. Ideal model for this research would be IVF procedure with donation of oocytes, where the quality of oocytes and receptiveness of endometrium before and after GnRH analogues treatment would be examined.  Patients with III and IV stage of endometriosis have a reduced ovarian reserve, weaker response of ovarium to stimulation, a high percentage of cancelled cycles and low rate of clinical pregnancies and deliveries, compared to patients with I and II stage of endometriosis. Despite a worse outcome of IVF, compared to patients with minimum and mild endometriosis and patients with tubal factor infertility, 31% of clinical pregnancies and almost 21% of deliveries of these patients is an excellent rate, making IVF still the most effective type of treatment that should be suggested to infertile patients with this problem, considering their very low rate of spontaneous pregnancies.  Surgical treatment of patients with endometriosis before entering IVF procedure still remains controversial. Results of the study show that laparoscopic excision of endometrium, is associated with permanent quantitative damage of ovarian reserve. This damage is, however, at least partly present even before surgery and caused by the very disease. Likewise, contrary to patients with decreased ovarian reserve due to age or early declining of ovarian function, patients with endometriosis who have undergone a surgical treatment, the quality of embryos and the rate of fertilization and implantation are not undermined. They even have the same rate of clinical pregnancies and deliveries as the patients with tubal infertility. Correlation of surgery and lower ovarian response in the process of gonadotropine stimulation should always be considered when patients with endometriosis enter the IVF procedure. Surgical expertise, extension of disease (especially when it comes to bilateral endometrioma), previous ovarian interventions; determine the effect of the surgery on the ovarian reserve.  In case of recurrent endometriosis, new operation worsens the IVF outcome and should be avoided. Except in case of excruciating pain and suspected ovarian masses, when a patient with recurrent endometriosis should immediately be involved in IVF procedure without new surgery.  An algorithm of approach to patients with endometriosis and infertility problem has been suggested. Patients with infertility problem and suspected endometriosis should immediately be sent to diagnostic and therapeutic laparoscopy. If after the surgery endometriosis is qualified as histopathological, patient should undergo GnRH analogue therapy and should be offered IVF as an optional treatment. Patients with infertility problem, who have undergone a surgical procedure for endometriosis and have recurrent endometriosis, should immediately be offered IVF with a possible treatment with GnRH analogues for a period of three months Univerzitet u Nišu Medicinski fakultet Lilić, Vekoslav Popović, Jasmina Kopitović, Vesna 2013 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1485 https://fedorani.ni.ac.rs/fedora/get/o:904/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024751085 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1501 2015-10-16T00:00:00Z 2

Interakcija Th-17 imunskog odgovora i glutamatske ekscitotoksičnosti u patogenezi multiple skleroze : klinička i eksperimentalna studija : doktorska disertacija Interaction Between Th-17 Immune Response and Glutamate Excitotoxicity in the Pathogenesis of Multiple Sclerosis – Clinical and Experimental Study Kostić, Miloš S. 1982- Multipla skleroza, Limfociti, multiple skleroza, Th-17 ćelije, glutamat, ekscitotoksičnost, inflamacija, neurodegeneracija, glutamatski transporteri, glutamin sinteza multiple sclerosis, Th-17 cells, glutamate excitotoxicity, inflammation, neurodegeneration, glutamate transporters, glutamine synthetase Introduction: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) characterized by episodic neurological defects, disseminated in time and neuroanatomical localization. The central role in the development of inflammatory mediated lesions in MS is now attributed to autoreactive, myelin-specific CD4+ T lymphocytes, which are thought to regulate all immune mechanisms that lead to the myelin sheath damage. It was originally thought that these cells belong to the subpopulation of Th-1 cells, however, a number of nowadays studies indicate the importance Th-17 cells in the pathogenesis of the disease. In addition to demyelination, which is still considered to be the main pathological feature of the disease, in the last few years special attention in MS research has been given to neurodegenerative processes, considering that it has been shown that the clinical symptoms of the disease are directly related to the degree of axonal damage and loss. Recently, glutamate excitotoxicity is considered as a possible mechanism of neurodegeneration in MS. This is a phenomenon that occurs when the excessive amount of excitatory neurotransmitter glutamate, overactivates its receptors on the membranes of neurons and oligodendrocytes, which leads to the intracellular accumulation of Ca2+ ions and the consequent cell death. Aims of the Thesis: To examine the association of Th-17 mediated inflammation and glutamate excitotoxicity in the development of MS. To determine the potential molecular mechanisms by which inflammation stimulates glutamate excitotoxicity and the consequent neurodegeneration with special emphasis on the role of astrocytes. Materials and Methods: The study had two integral parts: a clinical part conducted on the human material and experimental part conducted on the primary cultures of rat astrocytes. The clinical study enrolled 79 patients, divided into two groups: a control group and a group of MS patients. The presence of a Th-17 cells in the CNS of the studied subjects was monitored by IL-17A levels in the cerebrospinal fluid (CSF) determined by ELISA (Enzyme Immunosorbent Assay) method; while glutamate level was used to estimate excitotoxic damage by HPLC (High Performance Liquid Chromatography) method. The experimental Тh-17 имунски одговор и глутаматска ексцитотоксичност у патогенези МС др Милош Костић 10 study was carried out on the primary cultures of rat astrocytes. In order to investigate the effects of IL-17A on astrocyte ability to uptake and metabolize glutamate, cell cultures were stimulated with increasing concentrations of recombinant rat IL-17A protein, and then used for gene expression analysis of glutamate transporter (GLAST and GLT-1) and the enzyme glutamine synthetase, by PCR (Polymerase Chain Reaction). Investigation of IL-17A effect on astrocyte ability to release glutamate, was conducted in basal conditions and under conditions of elevated and reduced extracellular Ca2+. Astrocyte cultures were stimulated with the rising concentrations of recombinant rat IL-17A protein, and then glutamate secretion was followed up by the level of glutamate in the cell supernatants by HPLC. Results: Patients suffering from MS had a significantly higher level of IL-17A in the CSF compared to the control subjects (P <0.005), which was directly related to the level of glutamate (rs = 0.368, P <0.05). The level of IL-17A was also directly related to the number of neutrophils in the CSF (rs = 0.426, P <0.05) and blood-brain barrier disruption (rs = 0.440, P <0.05), whereas a negative correlation between CSF IL-17A level and disease duration was observed (rs = -0.466, P <0.01). In the experimental study it has been shown that IL-17A in lower concentrations (10, 25, 50 ng/mL) reduces glutamate transporter and glutamine synthetase gene expression in astrocytes, however, this effect was lost when IL-17A was used in higher dose (100 ng/mL). IL-17A did not significantly modify glutamate secretion in basal conditions, but following Ca2+ stimulation, and after Ca2+ removal from culture medium, IL-17A stimulated glutamate release from astrocytes in dose-dependent manner. Conclusions: IL-17A plays an important role in the complex cytokine network that mediates MS pathogenesis. For the first time direct relationship between Th-17 immune response and glutamate excitotoxicity is reported, which could be a missing link between inflammatory and neurodegenerative processes in MS. Three mechanisms by which IL-17A stimulates extracellular glutamate increase to excitotoxic levels are postulated. Firstly, IL-17A reduces astrocyte ability to uptake and metabolize glutamate and in addition IL-17A also stimulates Ca2+ dependent glutamate release from astrocytes. Univerzitet u Nišu Medicinski fakultet Čolić, Miodrag 1953- Stojanović, Ivana, 1962- Vojinović, Slobodan Marjanović, Goran Obradović, Dragana 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1501 https://fedorani.ni.ac.rs/fedora/get/o:905/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024963309 sr Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)

oai:eteze.ni.ac.rs:1502 2015-10-16T00:00:00Z 2

Protektivno dejstvo modulatora oksidativnog i nitrozativnog stresa u neuroinflamaciji - eksperimentalna i klinička studija : doktorska disertacija THE PROTECTIVE EFFECTS OF OXIDATIVE AND NITROSATIVE STRESS MODULATORS IN NEUROINFLAMMATION – EXPERIMENTAL AND CLINICAL STUDY Ljubisavljević, Srđan 1981- Neuroinflamacija, oksidativni stres, nitrozativni stres oxidative stress, nitrosative stress, neuroinflammation Neuroinflammation is recognised as the leading mechanism in development of many of neurological diseases, including multiple sclerosis (MS). Recently published papers suggest biphasic MS pathogenesis which is based on neuroinflammation, which prevails in the early MS phase, and also neurodegeneration, which predominates in the later stage of the disease, at the time when accumulated neurological disability occurs. The invasion of central nerve system (CNS) by activated immune cells is established as the main part of disease initiation, while oxidative and nitrosative stress participation, through their mediators, as well as glutamatergic excitotoxicity, although recognised as important factors in disease pathophysiology, are still insufficiently tested. Starting with weak and conflicting results, found in recently performed studies, which have evaluated oxidative and nitrosative stress participation in neuroinflammation, the general aim of the actual investigation was to more accurately define the role of named factors in acute attacks of experimental and clinical neuroinflammation, at the same time investigating mutual correlations of those biomarkers with morphological and neurological characteristic of neuroinflammatory acute attacks. In the experimental part, the stated model of neuroinflammation – the acute model of experimental autoimmune encephalomyelitis (EAE), was used. The EAE animals were treated with selective inhibitor of inducible nitric oxide synthase (iNOS), aminoguanidine (AG), and, also, with antioxidant, N acetyl L cysteine (NAC). The potential protective effects of those agents were tested according to biochemical (concentration NO2 i NO3, MDA, GSH, SOD), immunohistochemical (GFAP, EAAT1, OX42, ED1 and iNOS expression) and neurological characteristics of neuroinflammation. On the other side, in the clinical part, the values of nitrosative and oxidative stress parameters (concentration of NO2 i NO3, MDA, AOPP, SH groups, SOD) were evaluated in hemolysates, plasma and cerebrospinal fluids of patients in acute attacks of different clinical phenotypes of neuroinflmamation, defined as clinically isolated syndrome of CNS (CIS) and early defined relapse remitting multiple sclerosis (RRMS). The obtained values of named parameters were correlated with radiological, clinical and paraclinical findings of neuroinflammation. The obtained data show increased oxidative stress intensity in all parts of CNS during accute EAE as well as in all tested media obtained from CIS and RRMS patients during their relapses. The closed correlations between parameters of oxidative stress and morphological and neurological findings of neuroinflammation suggest the relevancy of oxidative stress in pathogenesis of accute attacks in both experimental and clinical neuroinflammation. In compliance with expected, the higher values of antioxidative capacity were demonstrated in CIS, compared to RRMS patients. However, the higher level of oxidative disorders, based on obtained values of MDA and AOPP, were also demonstrated in these patients. These results are understood as the consequences of higher reactive adequacy of the body and CNS, in CIS patients (due to shorter disease duration). Thus, the prooxidative processes are more pronounced in these patients as an adaptive phemonenon in suppression of neuroinflammation (through some of the known physiological functions), but due to intensive, uncontrolled generation of reactive oxygen species (ROS), detrimental effects are accumulated. Inversely, the general and CNS antioxidative capacity were decreased in RRMS patients due to their continuous exposition to ROS, which explains oxidative stress intensity and worse radiological and clinical findings, which DOKTORSKA DISERTACIJA was confirmed by the obtained correlations. The obtained results show increased level of nitric oxide (NO.) during neuroinflammation attacks, when NO. exerts direct or indirect pathological effects on CNS tissues. The CNS disorders in neuroinflammation are also mediated by glutamatergic excitotoxicity, caused by increased level of glutamate as the consequence of astrocytes activation. The increased expression of iNOS, and other parameters of glial cell activity (GFAP, OX42, ED1) as well as glutamatergic excitotoxicity (EAAT1) were found in imunohistochemical analysis of forebrain section obtained from EAE animals. The protective biochemical, imunohistochemical and neurological effects were demonstrated after AG administration and thiol supplementation by NAC. Also, in the clinical part, the oxidative and nitrosative stress importance in the pathogenesis of acute neuroinflammatory attacks were demonstrated, while both general and CNS oxidative and nitrosative profile were different in patients with different clinical phenotypes of neuroinflammation. The significant correlations between tested parameters and clinical and radiological features, as well as disease duration, were obtained in CIS and RRMS patients. These data suggest the closed correlations between disease duration and the worse radiological and neurological score, and decreased antioxidative and antinitrosative profile, as well as increased, general and CNS, oxidative and nitrosative stress. The similar correlations were obtained between all tested parameters and other general parameters of biological and biochemical syndrome of inflammation, in both, CIS and RRMS group. The obtained results give an advanced insight into the roles and imoprtances of oxidative and nitrosative stress during neuroinflammation and offer the posibility for antioxidative and antinitrosative treatments in accute attacks of neuroinflammation. In this way, the diseases caused by neuroinflammation might be controlled in early phases whose characteristic is reversibility, at the same time delaying later phases which are accompanied with irreversible neurological disabilities. Although there are not ideal biomarkers of neuroinflammation, some of here tested oxidative and nitrosative stress parameters might serve as surogat biomarkers for the earliest diagnosis, tracking and assessing neuroinflammation intensity, and its radiological and clinical correlates. Univerzitet u Nišu Medicinski fakultet Stojanović, Ivana 1962- Vojinović, Slobodan Kostić, Vladimir 1953- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1502 https://fedorani.ni.ac.rs/fedora/get/o:906/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024857837 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1503 2015-10-16T00:00:00Z 2

Morfometrijska i imunohistohemijska analiza struktura adenohipofize uključenih u sistem hipotalamo-hipofizno-adrenalne osovine tokom starenja čoveka : doktorska disertacija MORPHOMETRIC AND IMMUNOHISTOCHEMICAL ANALYSIS OF THE ADENOHYPOPHYSIS STRUCTURES INVOLVED IN THE SYSTEM OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS DURING THE AGING PROCESS Ljubomirović, Miljana N. 1980- Adenohipofiza, adenohipofiza, hipofiza, HPA osovina, starenje adenohypophysis, pituitary gland, HPA axis, aging The aging in men is accompanied by an increase in the presence of connective tissue in all the organs and tissues, and with increase of corticotrophs and folliculostellate cells in adenohypophysis, which can affect the function of the HPA axis in healthy elderly individuals. Objective of the research was to perform quantification of structural changes during aging (cellularity, presence of the connective tissue and blood flow), collagen type IV, corticotrophs and folliculostellate cells on the pituitary tissue, obtained at autopsy, using histochemical, immunohistochemical and morphometric methods. Histochemical part of the research showed an increase of the cell size that occured during normal aging in the adenohypophysis. The analyzed cells of the adenohypophysis were significantly larger and, at the same time, they were characterized by a substantially more regular shape in female in comparison to the male patients cases. Differences in the cellular composition of the pituitary tissue were observed in cases of the opposite sex and the significant higher number of basophils in males was noted. Hypertrophy of the cells was accompanied by proliferation of the pituitary connective tissue, as well as by it’s poarer vascularization during aging. Results of the immunohistochemical part of the study confirmed that there was an increase in the average volume densities of the folliculostellate cells and corticotrophs. The increase in the presence of type IV collagen was also present and the obtained result is consistent to statistically significant increase in the presence of the connective tissue in the adenohypophysis during the aging process, which we observed in the histochemical part of our study. Univerzitet u Nišu Medicinski fakultet Jovanović, Ivan Čukuranović, Rade Ugrenović, Slađana Stefanović, Natalija 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1503 https://fedorani.ni.ac.rs/fedora/get/o:907/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024857325 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1504 2015-10-16T00:00:00Z 2

Clinical and biochemical assessment of endothelial dysfunction and inflammation in renal transplant recipients : PhD dissertation KLINIČKO-BIOHEMIJSKI POKAZATELJI ENDOTELNE DISFUNKCIJE I INFLAMACIJE KOD PACIJENATA SA TRANSPLANTIRANIM BUBREGOM Stojanović, Dijana 1976- bubrezi, transplantacija bubrega, ADMA, SDMA, аdhezioni molekuli, bubrežnа disfunkcijа, dislipidemija, eNOS, inflamacija, krvni pritisak, renаlаza ADMA, SDMA, adhesion molecules, blood pressure, dyslipidemia, eNOS, inflammation, kidney transplantation, renalase, renal dysfunction Introduction. Renal replacement therapy remains the treatment of option for patients in end stage renal disease. The most frequent cause of late allograft loss is cardiovascular disease, which constitutes the leading cause of death of renal transplant recipients (RTR). When compared with the general population, RTR show a four-fold greater risk for CVD, and a two-fold higher risk for cardiovascular death. Renal transplant dysfunction can be considered as a traditional risk factor, while high sympathetic activity and accumulation of the endogenous inhibitor of endothelial NO synthase (eNOS), asymmetric dimethylarginine (ADMA) are factors peculiar to chronic renal failure. eNOS can be strongly inhibited by ADMA, whose accumulation in plasma may play an important role in endothelial dysfunction. ADMA is an uremic toxin that can be considered as parameter of endothelial dysfunction. ADMA, also, causes local vasoconstriction when infused intra-arterially. Symmetric dimethylaginine (SDMA) does not inhibit NOS directly, and is also elevated in patients with renal failure, its levels, better than ADMA, correlate with glomerular filtration rate (GFR). ADMA was proposed to be a marker for atherosclerotic changes, and for the assessment of cardiovascular morbidity and mortality. Atherosclerosis is today described as a disease where inflammation is the dominant pathological and biochemical alteration. The development of the atherosclerotic plaque is closely linked to expression of different cellular adhesion molecules (CAMs), that are essential mediators, playing a central role in the recruitment of inflammatory cells to the site development. Many factors were demonstrated to increase concentration of cellular adhesion molecules: hypertension, immunosuppressive therapy, autoimmune disease and cell mediated allograft rejection. These CAMs can be measured in plasma and therefore may represent promising biomarkers that may reflect underlying endothelial activation and vascular inflammation. Besides inflammation many studies have generally suggested a positive association between dyslipidemia and end stage renal disease and advanced chronic kidney failure. Renal disease is associated with profound abnormalities in lipids and lipoprotein metabolism and in renal transplant recipients hyperlipidemia is a well known feature. It has been suggested that dyslipoproteinemia observed in kidney disease contributes to the progression of glomerular and tubular lesions, with deterioration to end stage renal disease. Factors that induce post-transplant dyslipidemia include age, body weight, pre-transplant lipid levels, presence of proteinuria and allograft dysfunction. Standard immunosuppressive therapy usually consists of triple drug therapy of three drug classes: calcineurin inhibitors, anti-proliferative agents and corticosteroids. Corticosteroids and cyclosporine, besides the nephrotoxic effect, seem to be one of the main contributing factors that influence the post-transplant lipidemic profile. Cyclosporine plays an independent role in elevating cholesterol levels by modulating the low density lipoprotein (LDL) receptors. Corticosteroids, cyclosporine and tacrolimus (to a lesser degree than cyclosporine) increase post-transplant cholesterol and triglycerides levels, usually in dose dependent fashion. Elevated total and LDL cholesterol occur in about 60% and hypertriglyceridemia in about 35%, whereas low high density (HDL) cholesterol is present in only 15% of renal transplant recipients. Enhanced sympathetic activity is frequently reported in end stage renal disease, and such activation declines, but does not normalize, after successful kidney transplantation. Renalase is a new flavoprotein that regulates sympathetic tone and blood pressure. It is secreted by the kidney and is reported that has monoamine oxidase (MAO) activity, therefore may metabolize catecholamines. Cardiomyocytes, liver and skeletal muscles also secrete renalase, and it was found in peripheral nerves, central nervous system, adrenals, adipose tissue, 12.5-day-old embryo and endothelium. It circulates in the blood as a proenzyme waiting for elevated catecholamines for activation. The purpose of the study was to observe parameters of endothelial dysfunction (parameters of chronic inlammation and nitrosative stress), lipid profile disturbances and the level of sympathetic activity in the stable renal transplant recipients, to assess correlations between renal dysfunction and inflammatory biomarkers, lipid profile disturbances, nitrosative stress and sympathetic activity, as well as potential differences in these parameters in regard to immunosuppressive protocol, and among them to hypothesize the best independent predictor, and predictors of early renal dysfunction after multivariate modeling (adjustment for age, body mass index, hypertension, smoking and diabetes mellitus). Methods. We enrolled 73 renal transplant recipients, who were greater than 12 months post-renal transplant surgery, had a stable graft function, no clinically present cardiovascular disease and were on standard immunosuppression. The study was conducted between March and November 2012 at the Clinic for Nephrology, Dialysis and Transplantation, Clinical Centre Nis. Ethics Committee of Medical Faculty Nis approved the study and fully informed written consent was obtained from each patient. Results. Significant differences were found between clinical and control group in sistolic blood pressure, (p<0.001), diastolic blood pressure, (p<0.001), urea (p<0.001), creatinine (p<0.001), creatinine clearance (p<0.001), hemoglobin (p=0.003), white blood cells, (p=0.003), total cholesterol (p<0.001), non-HDL (p<0.001) and Tg (p<0.001). Plasma concentration of nitrates (p<0.001), eNOS (p<0.001), ADMA (p=0.001), SDMA (p<0.001), renalase (p<0.0001), ICAM-1 (p<0.001), and VCAM-1 (p<0.001), were statistically increased with regard to controls. Non-adjusted OR showed that there was a significant risk of reduced GFR in patients with total cholesterol higher than 5.19 mmol/L, LDL cholesterol≥4.1 mmol/L, non-HDL≥4.2 mmol/L and higher VCAM-1 concentration. After adjustment for age and in multivariable model OR showed a significant risk for reduced GFR in patients with total cholesterol ≥5.2 mmol/L, LDL≥4.1 mmol/L, non-HDL≥4.2 mmol/L and higher VCAM-1 concentration. HDL, triglycerides, CRP and lipoprotein ratios did not have any significance as predictors of renal dysfunction. Finally, there were no differences in all evaluated parameters between groups in regard to immunosuppressive therapy. Total cholesterol, LDL, non-HDL and VCAM-1 are strong and independent predictors of renal dysfunction in stable renal transplant recipients. In contrast HDL, CRP, triglycerides and ICAM-1 did not seem to have any impact on renal dysfunction. Non-adjusted OR showed that there was a significant risk of reduced eGFR in transplant recipients with increased renalase activity (p=0.026); age-adjusted OR showed a significant risk of reduced eGFR with increased renalase activity (p=0.042), also after multivariable adjustment (p=0.032). Increased plasma eNOS activity was protective factor for eGFR (p=0.011), also after adjustment for age (p=0.045), and after multivariate modeling, eNOS was shown to be protective factor for eGFR (p=0.014). Significant differences with respect to immunosuppression were in plasma renalase in patients maintained on cyclosporine (p=0.027), as well as differences in eGFR (p=0.034). We found statistically significant inverse correlation between renalase and eGFR (p<0.001), positive correlation between renalase and creatinine (p=0.003), total cholesterol (p<0.001), LDL-cholesterol (p=0.046), and non-HDL cholesterol (p=0.01). There was a significant difference in plasma renalase with regard to chronic kidney disease stages (p<0.001). Renalase correlated with leukocytes, but did not correlate with C-reactive protein. Renalase did not correlate with any of parameters of endothelial dysfunction, neither with some demographic data (gender, age, time or type of transplantation, risk factors). There were no differences in renalase activity with regard to antihypertensive therapy. Conclusion. Renalase was shown to be strong predictor for decreased eGFR in stable renal recipients. eNOS was identified as a strong protective factor for eGFR. Renalase strongly and inversely correlated with eGFR, positively with creatinine and lipid disturbances, but did not correlate with endothelial dysfunction parameters, and is most probably determined by kidney function. Total cholesterol, LDL, non-HDL and VCAM-1 strongly and inversely correlated with glomerular filtration rate and were shown to be independent predictors for decreased GFR, as well as predictors by multivariate modeling. In contrast there was no correlation of HDL, CRP, triglycerides and ICAM-1 with glomerular filtration rate. All evaluated lipid and inflammation parameters did not differ between the groups in respect to immunosuppression therapy protocol. Renalase was significantly higher in the group of patients on cyclosporine. Univerzitet u Nišu Medicinski fakultet Bojanić, Vladmila Radenković, Sonja 1949- Cvetković, Tanja 1965- Kocić, Gordana, 1957- Živančević Simonović, Snežana 1960- 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1504 https://fedorani.ni.ac.rs/fedora/get/o:908/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024839917 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1505 2015-10-16T00:00:00Z 2

Zatvaranje strelne rane primenom fibrinskog lepka sa antibiotikom : eksperimentalna studija : doktorska disertacija THE EXPERIMENTAL CLOSURE OF THE GUNSHOT WOUNDS BY FIBRIN GLUE WITH ANTIBIOTICS Đenić, Nebojša S. 1963- Strelne rane, puška, primarna hirurška obrada, fibrinski lepak, antibiotik, eksperiment automatic rifle, primary surgery, fibrin glue, antibiotic, experiment Introduction. Primary delayed suture (PDS) of gunshot wound is used in the next 4-7 days from primary surgery (PS). This period coincides with the fibroblastic phase of wound healing. Fibrin glue has been used as a matrix for the local dosed release of antibiotics. Objective. Create the preconditions for the gunshot wounds closing without complications by the application of fibrin glue with antibiotics (FGA) 24 hours after primary surgical treatment. Methods. Fourteen pigs were wounded in the gluteofemoral region by the rifle M70AB2. All of them were treated according to the principles of war surgery doctrine, but seven of them after PS were treated with FGA (cephtriaxon and clindamycin). Wound healing was followed from clinical, laboratory, microbiological, histopathological (Hp) and MSCT side. Results. From clinical and Hp aspect, after surgical treatment, in both groups were not found signs of additional necrosis and infection. Laboratory values WBC, Gr, PLT, ALT, AST, LDH, CRP, and CK, after initial jump caused by trauma, go to normal values by 4-7 days in both groups. After taking wound smear, in group treated with FGA in vitro was not registered significant growth of bactery colonies, unlike the group treated with standard technique. Histopatology confirmed that use of FGA stimulated synthesis of young collagen in wound. Conclusion. Wounds caused by automatic rifle M70AB2 (7,62 mm), treated with FGA after PS and closed 24 hours later with PDS, in further evolution did not lead to development of complications. That is an advantage compared to the standard technique, where wounds are closed within 4-7 days. Univerzitet u Nišu Medicinski fakultet Višnjić, Milan 1950- Mitković, Milorad, 1950- Stanojević, Goran Jevtić, Miodrag Popović, Zoran 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1505 https://fedorani.ni.ac.rs/fedora/get/o:909/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024837101 sr Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)

oai:eteze.ni.ac.rs:1506 2015-10-16T00:00:00Z 2

Karakteristike i međusobna povezanost empatije i roditeljstva kod adolescenatasa poremećajem ponašanja : doktorska disertacija CHARACTERSTICS AND INTERCONNECTEDNESS OF EMPATHY AND PARENTING IN THE ADOLESCENTS WITH CONDUCT DISORDER Kostić, Jelena S. 1973- Adolescenti, odbacivanje, prihvatanje, empatija, roditeljsko ponašanje empathy, parental acceptance/rejection, conduct disorder The main objective of this study was to investigate the characteristics of empathy as a special form of compassion and understanding of other people’s perspective and the dimensions of parental acceptance on one side and rejecting on the other, as well as their interconnectedness in groups of adolescents with and without conduct disorder. Another aim was to investigate the relationship between empathy and perceived parental behavior and sociodemographic and family variables in both examined groups, as well as the relationship between empathy and perceived parenting and the level of the level of externalizing problems in the group of adolescents with conduct disorder. The sample was comprised of 86 adolescents with a clinical diagnosis of conduct disorder (43 males and 43 females), mean age 16.49 ± 1.94. The control group consisted of 85 general population adolescents (40 males and 45 females), mean age 16.95 ± 1.77. All examinees gave answers to questions from the following self-report questionnaires: a structured questionnaire constructed for the purpose of this research, the Youth Self Report (YSR, Achenbach & Rescorla, 2001), for young people aged 11 to 18, the Interpersonal Reactivity Index (IRI, Davis, 1983) and the Parental Acceptance/Rejection Questionnaire (PARQchild version, Rohner, 1984). The results suggest that the level of empathy is lowered in adolescents with conduct disorders compared to the healthy population of adolescents, and that it is associated with both sociodemographic variables and parental acceptance/ rejection. Compared with the group of examinees without conduct disorder, the association pattern between empathy and parental rejection is specific in terms of a positive correlation between personal distress and perceived maternal rejection. These findings may have practical application in the context of targeting interventions at empathy and parenting skills training. Preventive work with adolescents who have problems with empathy associated with the problems of parental acceptance may help prevent the development, or at least alleviate the symptoms, of this increasingly frequent disorder in our society. Univerzitet u Nišu Medicinski fakultet Nešić, Milkica 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1506 https://fedorani.ni.ac.rs/fedora/get/o:910/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/1024845805 sr Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)

oai:eteze.ni.ac.rs:1594 2015-10-16T00:00:00Z 2

Menadžment konsalting kao podrška rastu i razvoju malih i srednjih preduzeća : doktorska diseertacija MANAGEMENT CONSULTING AS SUPPORT TO GROWTH AND DEVELOPMENT OF SMALL AND MEDIUM ENTERPRISES Dukić, Dragan, 1961- Preduzeća Summary: Economic growth and development is highly dependent on the ability of SMEs to develop and realize their potential for growth. At the same time, the ability of SMEs to grow is highly dependent on managerial knowledge and skills of people who are at the helm of the enterprise. In Serbia, SMEs are generally managed by owners which do not have adequate managerial skills. Existing methods of management training and passive learning do not provide the level of knowledge and skills required in present competitive environment. Because of that, there is very strong need for external professional support and adequate training, both through formal and informal education system, and in the immediate practice. This paper looks at the management consulting as a service and a process, especially as one of the sources for acquiring practical management knowledge and skills. More specifically it presents and analyzes the specifics of management consulting services to small and medium-sized enterprises, as well as services that are specific to businesses of this size. It also shows the importance of ethical aspects of management consulting in the SME sector, and the importance of trust and mutual relations between consultants and clients. The empirical part of the research includes analysis of small and medium-sized enterprises of different sizes and ages, especially in terms of actual or potential need for specific management consulting services. We used a survey method, to determine the attitudes of entrepreneurs and SME owners toward management consulting, its usefulness, the needs of the entrepreneurs and the owners to use consulting services, as well as the reasons for (non) use of consulting services. In particular, analyzing the needs of the growing SMEs, depending on the size of the enterprises, wе verified the hypothesis that smaller company has less possibility to use the specific consulting services, but greater need for informal, general business consulting and interdisciplinary education. We analyzed the differences between institutional and private providers of consulting services to SMEs. By comparing the availability and use of consulting services of institutional and private consultants, and quality of these services, there are some interesting information and conclusions about the need for a meaningful institutional consulting agency to focus on universal approach, and private on provision of specific consulting services. A survey has undoubtedly proved that consulting support to the SME sector in Serbia is still at an early stage, without serious regulatory mechanisms. Government has a key role in the development of institutions and programs to support the SME sector, as well as facilitating the development of the market of professional organizations to support SMEs. The results of this study can serve as a basis for redefining the mission and work programs of the institutions for non-financial support to the SME sector in Serbia, to create more meaningful local and regional strategies for development of the SME sector, as well as the improving of legislation in the field of business and management consulting. Univerzitet u Nišu Ekonomski fakultet Predić, Biljana 2014 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1594 https://fedorani.ni.ac.rs/fedora/get/o:921/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533614742 sr Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)

oai:eteze.ni.ac.rs:1664 2015-10-16T00:00:00Z 2

Design and optimization of electrical contacts and thermal cutoffs : PhD Dissertation -updated version- Prijić, Aneta Electrical contacts, Thermal cutoffs This Dissertation is focused on the design and optimization of the two types of metal based switching devices: rivet electrical contacts and S–type thermal cutoffs. Theoretical basis of the electrical contacts design is employed for the adequate contact material selection, determination of the proper set of contact geometry and dimensions, and estimation of the minimum contact force value. Contacts of the solid and clad type, with rounded head are considered within two supporting structures. Obtained results of 3–D simulation of mechanical, electrical and thermal characteristics of the selected contacts in a steady state regime are presented. Simulations are carried out in the coupled physical domains by the direct solving method. Special emphasis is put on the dependencies of the operating temperature and maximum equivalent stress in the contacts under various working conditions. On the basis of the obtained results, optimization of the rivet electrical contacts is realized by the appropriate selection of the contact material, determination of the geometry and dimensions of contacts and definition of the rated current value. The optimization was conducted by functional, economic, ecological and reliability issues. Feasibility of contacts implementation into the specific switching devices with predefined rated currents and number of switching cycles before the failure are outlined. Analyzed dependencies and optimization results are described in details. Theoretical basis of design and optimization procedures of thermal cutoffs are summarized. Parameters of functionality, quality and reliability are specially considered, since they are crucial for the appropriate choice of geometry, dimensions and materials of cutoffs constitutive elements. Thermodynamic and microstructure characterization of the low melting alloys for thermal cutoffs purposes are elaborated. A new method for evaluation of the liquidus surfaces of the ternary systems is proposed. It is based on the standard 3–D surface modeling principles, and is applicable for any ternary system whose phase diagrams of binary subsystems and a few appropriate experimental points are known. The liquidus temperature can be determined from this 3–D surface by geometrical rules for any arbitrary composition of the ternary system. Moreover, the range of compositions of ternary alloys that have desired liquidus temperature can be easily extracted. Microstructure characteristics of the two eutectic low–melting alloys are also presented. Investigation was performed by SEMand EDS techniques, and the obtained results are discussed from the aspects of thermal cutoff technology development. The results of 3–D electrical and thermal simulation of thermal cutoffs with two cutoff temperatures for the rated current of 12 A and rated voltage of 250 V (S–95 and S–138 type) are analyzed. The functionality and quality parameters of thermal cutoffs are determinedby the simulation. Optimization of thermal cutoffs geometry anddimensions is proposed considering functional, economic and technological aspects. The results of electro–thermal characteristics investigation of S–138 thermal cutoff industrial prototypes by the thermovision imaging are presented. Thermal boundary conditions for the simulation, which are crucial for the successful optimization of the cutoffs, are set according to the obtained results. On the basis of the temperature distributions in the cutoffs under different working conditions, the temperature rise due to the self–heating is registered, the cutoff temperature is determined, and the response time of the cutoffs is evaluated. Thermal characteristics of the housing and conductive elements of the cutoffs are also analyzed. As a result of the performed design and optimization procedures of thermal cutoffs, a technology line for their industrial production is presented. Complete process flow diagram for the S–type cutoffs is proposed. It includes preparation and assembling of the constitutive elements and quality and reliability testing procedures. Univerzitet u Nišu Elektronski fakultet Biljana Pešić 2015 PhD thesis application/pdf http://eteze.ni.ac.rs/application/showtheses?thesesId=1664 https://fedorani.ni.ac.rs/fedora/get/o:924/bdef:Content/download https://plus.cobiss.net/cobiss/sr/sr/bib/533068182 en Autorstvo 3.0 Srbija (CC BY 3.0) 1775661489804